Results 111 to 120 of about 77,428 (274)

Renal function impairment in children with intestinal failure receiving parenteral nutrition: A descriptive cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Children with intestinal failure are at risk for kidney dysfunction; however, the contributing factors are not well established. We aimed to describe risk factors associated with glomerular and tubular renal dysfunction in children with intestinal failure.
Amanda M. Braga da Mata, Heitor Pons Leite, Eduardo F. Hatanaka, Mariana Janiques Barcia Magalhães Fonseca, Marta Liliane de Almeida Maia, Giovana S. G. Sabio, Maria Fernanda C. de Camargo, Paulo C. Koch Nogueira   +7 more
wiley   +1 more source

A RARE HEREDITARY DISEASE: PSEUDOHIPOPARATHERIOSIS TYPE 1a IN THE PRACTICE OF A PEDIATRIC ENDOCRINOLOGIST

Мать и дитя в Кузбассе, 2022
Pseudohypoparathyroidism (PGP) is a rare hereditary disease characterized by clinical and laboratory signs of hypoparathyroidism against the background of an increased level of parathyroid hormone (PTH) in the blood.
Алла Дмитриевна Алексеева, Наталья Александровна Жданова, Ирина Владимировна Болгова, Светлана Ивановна Елгина, Вадим Гельевич Мозес, Елена Владимировна Рудаева, Кира Борисовна Мозес, Яэль Центер   +7 more
doaj  

Functional characterization and evolution ofPTH/PTHrP receptors: insights from the chicken [PDF]

, 2012
The parathyroid hormone (PTH)-family consists of a group of structurally related factors that regulate calcium and bone homeostasis and are also involved in development of organs such as the heart, mammary gland and immune system.
Canario, Adelino V. M., Cardoso, João CR, Pinheiro, Pedro L. C., Power, Deborah   +3 more
core   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Deletion of the nuclear localization sequences and C-terminus of PTHrP impairs embryonic mammary development but also inhibits PTHrP production.

PLoS ONE, 2014
Parathyroid hormone-related protein (PTHrP) can be secreted from cells and interact with its receptor, the Type 1 PTH/PTHrP Receptor (PTHR1) in an autocrine, paracrine or endocrine fashion.
Kata Boras-Granic, Pamela Dann, Joshua Vanhouten, Andrew Karaplis, John Wysolmerski   +4 more
doaj   +1 more source

Key Interaction Changes Determine the Activation Process of Human Parathyroid Hormone Type 1 Receptor

Journal of the American Chemical Society
The parathyroid hormone type 1 receptor (PTH1R) plays a crucial role in modulating various physiological functions and is considered an effective therapeutic target for osteoporosis. However, a lack of detailed molecular and energetic information about PTH1R limits our comprehensive understanding of its activation process.
Yue Zhang, Qingchuan Zheng, Arieh Warshel, Chen Bai   +3 more
openaire   +2 more sources

The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing-receptor (CaSR) mutation:relevance to autosomal dominant hypocalcemia type 1 (ADH1) [PDF]

, 2015
Autosomal dominant hypocalcemia type 1 (ADH1) is caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) and may lead to symptomatic hypocalcemia, inappropriately low serum parathyroid hormone (PTH) concentrations and ...
Allen M. Spiegel, Breitwieser, Dong, Drude, Enikö Kallay, Fadil M. Hannan, Gerard V. Walls, Gowen, Hannan, Hannan, Harding, Hofer, Hough, Hu, Hu, Huang, Jianxin Hu, John, Kinoshita, Kumar, Leach, Leach, Letz, Letz, Lia-Baldini, Loupy, M. Andrew Nesbit, Miedlich, Nemeth, Nemeth, Nesbit, Pearce, Pearce, Petrel, Rajesh V. Thakker, Raue, Roger D. Cox, Stechman, Tertius A. Hough, Thim, Valerie N. Babinsky, Vargas-Poussou, Watanabe, William D. Fraser, Yamamoto   +44 more
core   +1 more source

Mind the Gap: Predictors of Osteoporosis Treatment Following Fragility Fracture in Parkinsonism

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Fracture risk is increased in Parkinson's yet this risk is often not addressed. Objectives Our objective was to study the extent to which osteoporosis was treated, and predictors of treatment in a large representative cohort with parkinsonism.
Katie C. Naylor, Emily J. Henderson, Emma Tenison   +2 more
wiley   +1 more source

Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes

BMC Genetics, 2004
Background The adequacy of association studies for complex diseases depends critically on the existence of linkage disequilibrium (LD) between functional alleles and surrounding SNP markers.
Shen Hui, Dvornyk Volodymyr, Lu Yan, Liu Peng-Yuan, Zhao Lan-Juan, Long Ji-Rong, Liu Yong-Jun, Zhang Yuan-Yuan, Xiong Dong-Hai, Xiao Peng, Deng Hong-Wen   +10 more
doaj   +1 more source

Effect of carbohydrate feeding on the bone metabolic response to running [PDF]

, 2015
Bone resorption is increased after running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. This study investigated the immediate and short-term bone metabolic responses
Craig Sale, Ian Varley, Jonathan C. Y. Tang, Julie P. Greeves, Peake JM, Ruth M. James, Thomas W. Jones, William D. Fraser, Zweig MH   +8 more
core   +1 more source