Results 121 to 130 of about 29,683 (216)
Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.Lymphotropic nanoplatforms integrate multimodal imaging with therapeutic guidance to map sentinel and tumor‐draining lymph nodes, revealing functional drainage, metastatic involvement, and nodal accessibility, while providing mechanistic insight to support precision surgical and therapeutic interventions.
Xu Chen +7 more
wiley +1 more source
m.10010T>C Mitochondrial Disease: A Case Report With Hypoparathyroidism and Review of the Literature
American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1856-1861, August 2026.ABSTRACT Mitochondria are essential intracellular organelles that play a critical role in cellular metabolism, including the regulation of intracellular calcium signaling. Advances in genomic sequencing have facilitated the identification of rare pathogenic mitochondrial DNA (mtDNA) genetic variants in patients with unexplained endocrine disorders.
Jacob Mohr +5 more
wiley +1 more source
Laryngeal Ultrasound for Vocal Cord Palsy in Adults: A Meta‐Analysis of Diagnostic Studies
Australasian Journal of Ultrasound in Medicine, Volume 29, Issue 3, August 2026.ABSTRACT Background The standard test to diagnose vocal cord palsy in adults is laryngoscopy, which is invasive, whereas laryngeal ultrasound (LUS) is an alternative, non‐invasive method. We conducted a systematic review to determine the accuracy of LUS in diagnosing VCP in adults.
Uday S. Rao, Shripada C. Rao
wiley +1 more source
Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?
Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 334-344, August 2026.Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu +5 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.ITGA5/integrin α5β1 promotes PDAC progression by integrating fibronectin‐dependent adhesion, hypoxia‐associated ECM remodelling, pancreatic stellate cell/cancer‐associated fibroblast activation, desmoplasia and tumour‒stroma crosstalk. These processes contribute to impaired drug delivery and therapeutic resistance.
Chenzhe Ma, Yingying Wang, Yumin Li
wiley +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.ABSTRACT Background Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction. Objective This review summarizes current evidence on the roles of ATMs in obese adipose tissue and examines how macrophage polarization and metabolic ...
Yuanyuan Li +11 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 8, August 2026.ABSTRACT Transepithelial calcium absorption occurs via a transcellular or paracellular pathway. The intestinal transcellular pathway relies, at least partially, on the apical calcium channel transient receptor potential vanilloid 6 (TRPV6), whereas paracellular calcium (re)absorption occurs through tight junction proteins, including claudin‐2 (CLDN2 ...
Harneet Kaur Bhullar +6 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7280-7290, August 2026.ABSTRACT Aims While being recognised for stimulating pancreatic insulin secretion, GIP and GLP‐1 exert various extrapancreatic effects relevant in the context of incretin‐based therapies. Here, we evaluated the extrapancreatic effects of GIP and GLP‐1, separately and combined, on postprandial physiology in totally pancreatectomised individuals ...
Liva S. L. Krogh +8 more
wiley +1 more source
Iron Overload: Pathophysiology, Diagnosis and Monitoring
International Journal of Laboratory Hematology, Volume 48, Issue 4, Page 747-756, August 2026.ABSTRACT Iron overload is associated with significant health risks, underscoring the importance of understanding its pathophysiology as well as establishing accurate diagnostic and monitoring methods. Chronic iron overload is associated with either genetic disorders characterized by excessive iron accumulation (hereditary hemochromatosis), or is ...
Elena Chatzikalil +3 more
wiley +1 more source