Results 51 to 60 of about 77,428 (274)
Hormonal changes during aging and their effects on quality of life [PDF]
Exploration of Endocrine and Metabolic DiseasesHormonal dysregulation plays a central role in aging, exerting a profound, multidimensional impact on quality of life. This narrative review examines the impact of hormonal changes in understanding how age-dependent alterations in key hormonal axes ...
Carter Coggins +3 more
doaj +1 more source
PTHrP treatment of colon cancer cells promotes tumor associated-angiogenesis by the effect of VEGF [PDF]
, 2019 We showed that Parathyroid Hormone-related Peptide (PTHrP) induces proliferation, migration, survival and chemoresistance via MAPKs and PI3K/AKT pathways in colorectal cancer (CRC) cells.
Calvo, Natalia Graciela +4 more
core +1 more source
BMC Musculoskeletal Disorders, 2020 Background Fractures in older men are not uncommon and need to be healed as soon as possible to avoid related complications. Anti-osteoporotic drugs targeting Wnt/β-catenin and PTH (parathyroid hormone) to promote fracture healing have become an ...
Daocheng Liu +8 more
doaj +1 more source
Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome
Communications Biology, 2023 The parathyroid hormone receptor type 1 (PTH1R) is a G protein-coupled receptor that plays key roles in regulating calcium homeostasis and skeletal development via binding the ligands, PTH and PTH-related protein (PTHrP), respectively.
Ignacio Portales-Castillo +8 more
doaj +1 more source
Abnormal Renovascular Parathyroid Hormone-1 Receptor in Hypertension: Primary Defect or Secondary to Angiotensin II Type 1 Receptor Activation? [PDF]
Endocrinology, 2006 We previously reported that PTHrP-induced renal vasodilation is impaired in mature spontaneously hypertensive rats (SHR) through down-regulation of the type 1 PTH/PTHrP receptor (PTH1R), a feature that contributes to the high renal vascular resistance in SHR.
Sandra, Welsch +6 more
openaire +2 more sources
Physiological Reports, 2018 An active lifestyle is generally recommended for hypertensive patients to prevent subsequent end‐organ damage. However, experimental data on long‐term effects of exercise on hypertension are insufficient and underlying mechanisms are not well understood.
Katja Braun +4 more
semanticscholar +1 more source
Physiopathological Implications of 7TM Receptors [PDF]
, 2010 Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core +2 more sources
Modulation of β-catenin signaling by glucagon receptor activation. [PDF]
PLoS ONE, 2012 The glucagon receptor (GCGR) is a member of the class B G protein-coupled receptor family. Activation of GCGR by glucagon leads to increased glucose production by the liver.
Jiyuan Ke +8 more
doaj +1 more source
Understanding the Allosteric Modulation of PTH1R by a Negative Allosteric Modulator
Cells, 2022 The parathyroid hormone type 1 receptor (PTH1R) acts as a canonical class B G protein-coupled receptor, regulating crucial functions including calcium homeostasis and bone formation.
Mengrong Li +5 more
doaj +1 more source
Teriparatide in Two Patients With Mucopolysaccharidosis Type IVB. [PDF]
JIMD RepABSTRACT Mucopolysaccharidosis Type IV is a multisystem lysosomal storage disease characterized by severe skeletal dysplasia resulting from impaired degradation of the glycosaminoglycans keratan sulfate and chondroitin‐6‐sulfate. The condition is classified into Types A and B based on the underlying enzyme deficiency.
Wijnen M +5 more
europepmc +2 more sources