Results 51 to 60 of about 29,683 (216)

Type 1 Parathyroid Hormone Receptor (PTH1R) Nuclear Trafficking: Association of PTH1R with Importin α₁and β [PDF]

Endocrinology, 2006
Previous studies have shown that the type 1 PTH receptor (PTH1R), a class B G protein-coupled receptor, appears in the nucleus of target cells. Through immunofluorescence and deconvolution microscopy, we demonstrate that PTH1R, importin alpha(1), and importin beta are present within the nucleus and cytoplasm of osteoblast-like cell lines with the ...
Bryce W, Pickard, Anthony B, Hodsman, Laurence J, Fraher, Patricia H, Watson   +3 more
openaire   +2 more sources

Local variation in age‐related cortical expansion within and between cross‐sections of distal human long bones

The Anatomical Record, EarlyView.
Abstract Cortical bone expansion is an age‐related process where, through endosteal resorption and periosteal apposition, cross‐sectional diameter increases while cortical thickness decreases in long bone diaphyses. Local variation has been observed in this process between cross‐sectional locations, but few studies have examined directional variation ...
Gregory J. Wehrman, Alice F. Gooding, Adam D. Sylvester, Dawnie W. Steadman, Benjamin M. Auerbach   +4 more
wiley   +1 more source

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source

Hypersecretion of ACTH and PRL from pituitary adenoma in MEN1, adequately managed by medical therapy

Endocrinology, Diabetes & Metabolism Case Reports, 2017
A 54-year-old man had gastrinoma, parathyroid hyperplasia and pituitary tumor. His family history indicated that he might have multiple endocrine neoplasia type 1 (MEN1). MEN1 gene analysis revealed a heterozygous germline mutation (Gly156Arg). Therefore,
Shinsuke Uraki, Hiroyuki Ariyasu, Asako Doi, Hiroto Furuta, Masahiro Nishi, Takeshi Usui, Hiroki Yamaue, Takashi Akamizu   +7 more
doaj   +1 more source

EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells [PDF]

Journal of Molecular and Cellular Cardiology, 2010
Parathyroid hormone-related protein (PTHrP) and the parathyroid hormone type 1 receptor (PTH1R) are important regulators of vascular remodeling. PTHrP expression is associated to increased proliferation of vascular smooth muscle cells (VSMC). In contrast, signaling via the PTH1R inhibits cell growth.
Gyun Jee, Song, Stacey, Barrick, Kristen L, Leslie, Brian, Sicari, Nathalie M, Fiaschi-Taesch, Alessandro, Bisello   +5 more
openaire   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Fast-diffusing receptor collisions with slow-diffusing peptide ligand assemble the ternary parathyroid hormone–GPCR–arrestin complex

Nature Communications
The assembly of a peptide ligand, its receptor, and β-arrestin (βarr) into a ternary complex within the cell membrane is a crucial aspect of G protein-coupled receptor (GPCR) signaling.
Jonathan Pacheco, Karina A. Peña, Sofya Savransky, Alexandre Gidon, Gerald R. V. Hammond, John Janetzko, Jean-Pierre Vilardaga   +6 more
doaj   +1 more source

Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value

Frontiers in Oncology, 2021
Lung cancer is the leading cause of cancer-related death worldwide. Bone metastasis, which usually accompanies severe skeletal-related events, is the most common site for tumor distant dissemination and detected in more than one-third of patients with ...
Xupeng Chai, Xupeng Chai, Eloy Yinwang, Eloy Yinwang, Zenan Wang, Zenan Wang, Zhan Wang, Zhan Wang, Yucheng Xue, Yucheng Xue, Binghao Li, Binghao Li, Hao Zhou, Hao Zhou, Wenkan Zhang, Wenkan Zhang, Shengdong Wang, Shengdong Wang, Yongxing Zhang, Yongxing Zhang, Hengyuan Li, Hengyuan Li, Haochen Mou, Haochen Mou, Lingling Sun, Lingling Sun, Hao Qu, Hao Qu, Fangqian Wang, Fangqian Wang, Zengjie Zhang, Zengjie Zhang, Tao Chen, Tao Chen, Zhaoming Ye, Zhaoming Ye   +35 more
doaj   +1 more source

Angiotensin II Increases Parathyroid Hormone-Related Protein (PTHrP) and the Type 1 PTH/PTHrP Receptor in the Kidney [PDF]

Journal of the American Society of Nephrology, 2002
Angiotensin II (AngII) participates in the pathogenesis of kidney damage. Parathyroid hormone (PTH)-related protein (PTHrP), a vasodilator and mitogenic agent, is upregulated during renal injury. The aim of this study was to investigate the potential relation between AngII and PTHrP system in the kidney.
Oscar, Lorenzo, Marta, Ruiz-Ortega, Pedro, Esbrit, Mönica, Rupérez, Arantxa, Ortega, Soledad, Santos, Julia, Blanco, Luis, Ortega, Jesus, Egido   +8 more
openaire   +2 more sources

Parathyroid Hormone-Related Peptide Elicits Peripheral TRPV1-dependent Mechanical Hypersensitivity

Frontiers in Cellular Neuroscience, 2018
Bone metastasis in breast, prostate and lung cancers often leads to chronic pain, which is poorly managed by existing analgesics. The neurobiological mechanisms that underlie chronic pain associated with bone-metastasized cancers are not well understood,
Andrew J. Shepherd, Andrew J. Shepherd, Aaron D. Mickle, Aaron D. Mickle, Suraj Kadunganattil, Hongzhen Hu, Hongzhen Hu, Hongzhen Hu, Durga P. Mohapatra, Durga P. Mohapatra, Durga P. Mohapatra, Durga P. Mohapatra   +11 more
doaj   +1 more source