Results 31 to 40 of about 77,428 (274)
Autoactivation of Type-1 Parathyroid Hormone Receptors Containing a Tethered Ligand [PDF]
Journal of Biological Chemistry, 2000 Interactions between the N-terminal residues of parathyroid hormone (PTH) and the region of the PTH receptor containing the extracellular loops and transmembrane domains are thought to be critical for receptor activation. We evaluated this hypothesis by replacing the large N-terminal extracellular domain of the human type 1 PTH receptor (hP1Rc-WT) with
M, Shimizu, P H, Carter, T J, Gardella
openaire +2 more sources
Autosomal dominant hypocalcemia with a novel mutation: a case study and literature review
Journal of International Medical Research, 2022 Autosomal dominant hypocalcemia type 1 (ADH1) is a rare inherited disorder characterized by hypocalcemia with low parathyroid hormone (PTH) levels and high urinary calcium.
Yingying Wu +5 more
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Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor
Frontiers in Endocrinology, 2022 Parathyroid hormone 1 receptor (PTH1R) is a member of the class B family of G protein-coupled receptors, which are characterized by a large extracellular domain required for ligand binding.
Christoph Klenk +7 more
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Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase
Journal of Pharmacological Sciences, 2021 Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown.
Masaki Saito +5 more
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The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue
Biomolecules, 2021 Adipose tissue is an organ that shows great plasticity and is able to adapt to the conditions to which the body is subdued. It participates in the regulation of energetic homeostasis and has endocrine functions.
Adriana Izquierdo-Lahuerta
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Journal of Clinical and Translational Endocrinology Case Reports, 2021 We present a case of a 50-year-old woman with familial hypocalciuric hypercalcemia type 1 (FHH-1) that was missed during an initial evaluation of hypercalcemia in the setting of normal serum parathyroid hormone (PTH), leading to unnecessary ...
Akuffo Quarde +2 more
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Role of Parathyroid Hormone and Parathyroid Hormone-Related Protein in Protein-Energy Malnutrition
Frontiers in Bioscience-Landmark, 2023 Parathyroid hormone (PTH) is an endocrine peptide found exclusively in the parathyroid glands, whereas parathyroid hormone-related protein (PTHrP) is expressed in a wide range of tissues and organs and exerts endocrine, paracrine, and autocrine actions ...
Praopilad Srisuwarn +1 more
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Cell Communication and Signaling, 2023 Background Re-epithelialization is important in the process of wound healing. Various methods have been identified to expedite the process, but their clinical application remains limited.
Chunhao Zhou +8 more
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Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice
eLife, 2021 Osteoarthritis, a highly prevalent degenerative joint disorder, is characterized by joint pain and disability. Available treatments fail to modify osteoarthritis progression and decrease joint pain effectively. Here, we show that intermittent parathyroid
Qi Sun +13 more
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The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]
, 2013 The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves +3 more
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