Results 11 to 20 of about 77,428 (274)

Role of phospholipase D in parathyroid hormone type 1 receptor signaling and trafficking. [PDF]

Molecular Endocrinology, 2009
The role of phospholipase D (PLD) in the regulation of the traffic of the PTH type 1 receptor (PTH1R) was studied in Chinese hamster ovary cells stably transfected with a human PTH1R (CHO-R3) and in rat osteosarcoma 17/2.8 (ROS) cells. PTH(1-34) increased total PLD activity by 3-fold in CHO-R3 cells and by 2-fold in ROS cells.
J. Garrido, David S Wheeler, Luis Leiva Vega, P. A. Friedman, G. Romero   +4 more
semanticscholar   +3 more sources

Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival [PDF]

Journal of Bone and Mineral Research, 2015
Abstract   Osteocytes have a major role in the control of bone remodeling. Mechanical stimulation decreases osteocyte apoptosis and promotes bone accrual, whereas skeletal unloading is deleterious in both respects. PTH1R ablation or overexpression in osteocytes in mice produces trabecular bone loss or
M. Maycas, J. Ardura, Luis F. de Castro, B. Bravo, A. Gortázar, P. Esbrit   +5 more
semanticscholar   +3 more sources

Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia. [PDF]

Endocrinology, 1998
A single homozygous nucleotide exchange in exon E3 of the gene encoding the parathyroid hormone receptor type 1 (PTHR1) was identified in an infant with Blomstrand chondrodysplasia born to consanguineous parents. This alteration changes a strictly conserved proline residue at position 132 in the receptor's amino terminal extracellular domain to leucine.
A. Karaplis, B. He, M. Nguyen, I. Young, D. Semeraro, H. Ozawa, N. Amizuka   +6 more
semanticscholar   +4 more sources

Dimeric R25CPTH(1–34) activates the parathyroid hormone-1 receptor in vitro and stimulates bone formation in osteoporotic female mice

eLife
Osteoporosis, characterized by reduced bone density and strength, increases fracture risk, pain, and limits mobility. Established therapies of parathyroid hormone (PTH) analogs effectively promote bone formation and reduce fractures in severe ...
Minsoo Noh, Xiangguo Che, Xian Jin, Dong-Kyo Lee, Hyun-Ju Kim, Doo Ri Park, Soo Young Lee, Hunsang Lee, Thomas J Gardella, Je-Yong Choi, Sihoon Lee   +10 more
doaj   +2 more sources

Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. [PDF]

Molecular Endocrinology, 2015
AbstractThe parathyroid hormone receptor-1 (PTHR1) plays critical roles in regulating blood calcium levels and bone metabolism and is thus of interest for small-molecule ligand development. Of the few small-molecule ligands reported for the PTHR1, most are of low affinity, and none has a well-defined mechanism of action. Here, we show that SW106 and AH-
P. Carter, T. Dean, Brijesh Bhayana, A. Khatri, Raj Rajur, T. Gardella   +5 more
semanticscholar   +3 more sources

Agonist-regulated Cleavage of the Extracellular Domain of Parathyroid Hormone Receptor Type 1* [PDF]

Journal of Biological Chemistry, 2010
The receptor for parathyroid hormone (PTHR) is a main regulator of calcium homeostasis and bone maintenance. As a member of class B of G protein-coupled receptors, it harbors a large extracellular domain, which is required for ligand binding.
C. Klenk, S. Schulz, D. Calebiro, M. Lohse   +3 more
semanticscholar   +3 more sources

Eiken syndrome with parathyroid hormone resistance due to a novel parathyroid hormone receptor type 1 mutation: clinical features and functional analysis.

Journal of Bone and Mineral Research
We report two patients of east African ancestry with the same novel homozygous variant in the parathyroid hormone receptor type 1 (PTH1R). Both patients shared skeletal features including brachydactyly, extensive metacarpal pseudoepiphyses, elongated ...
Alistair Calder, J. Allgrove, Jakob Höppner, Moira Cheung, S. Alexander, Lorenzo Garagnani, Rajesh V Thakker, Harald Jüppner, Thomas J Gardella, Muriel Holder-Espinasse   +9 more
semanticscholar   +3 more sources

EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells. [PDF]

Journal of Molecular and Cellular Cardiology, 2010
Parathyroid hormone-related protein (PTHrP) and the parathyroid hormone type 1 receptor (PTH1R) are important regulators of vascular remodeling. PTHrP expression is associated to increased proliferation of vascular smooth muscle cells (VSMC). In contrast, signaling via the PTH1R inhibits cell growth.
G. Song, S. Barrick, Kristen L. Leslie, Brian M. Sicari, N. Fiaschi-Taesch, A. Bisello   +5 more
semanticscholar   +3 more sources

Parathyroid Hormone-related Peptide (hPTHrP) and Parathyroid Hormone-related Peptide Receptor Type 1 (PTHR1) Expression in Human Thymus [PDF]

Journal of Histochemistry & Cytochemistry, 2005
Parathyroid hormone-related peptide (hPTHrP) is expressed in human tissues and regulates cellular proliferation, differentiation, and apoptosis by an autocrine/paracrine loop. In rodent thymus, both parathormone and parathyroid hormone-related peptide (PTHrP) are expressed by thymic epithelial cells (TECs). The present study demonstrated by RT-PCR and
M. Gessi, G. Monego, L. Lauriola, N. Maggiano, F. Ranelletti   +4 more
semanticscholar   +3 more sources

Fast-diffusing receptor collisions with slow-diffusing peptide ligand assemble the ternary parathyroid hormone–GPCR–arrestin complex

Nature Communications
The assembly of a peptide ligand, its receptor, and β-arrestin (βarr) into a ternary complex within the cell membrane is a crucial aspect of G protein-coupled receptor (GPCR) signaling.
Jonathan Pacheco, Karina A. Peña, Sofya Savransky, Alexandre Gidon, Gerald R. V. Hammond, John Janetzko, Jean-Pierre Vilardaga   +6 more
doaj   +2 more sources