Results 11 to 20 of about 29,683 (216)

Core conformation of arrestin coupling to parathyroid hormone type 1 receptor

Nature Communications
The recruitment of β-arrestin (βarr) by G-protein-coupled receptor (GPCR) holds imperative importance in physiological processes, while the mechanisms underlying arrestin engagement with receptors remain obscure.
Xiuwen Zhai, Jia Guo, Qingya Shen, Li-Nan Chen, Gang Wang, Dan-Dan Shen, Changming Zhang, Xiaodong Xu, Chunyou Mao, Yan Zhang, Zhihong Liu   +10 more
doaj   +2 more sources

Parathyroid hormone and parathyroid hormone type-1 receptor accelerate myocyte differentiation [PDF]

Scientific Reports, 2014
The ZHTc6-MyoD embryonic stem cell line expresses the myogenic transcriptional factor MyoD under the control of a tetracycline-inducible promoter. Following induction, most of the ZHTc6-MyoD cells differentiate to myotubes. However, a small fraction does not differentiate, instead forming colonies that retain the potential for myocyte differentiation ...
Shigemi Kimura, Kowasi Yoshioka
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Parathyroid Hormone/Parathyroid Hormone-Related Peptide Type 1 Receptor in Human Bone [PDF]

Journal of Bone and Mineral Research, 2001
Abstract The parathyroid hormone/parathyroid hormone-related peptide (PTH/PTHrP) receptor (denoted as PTH-1R) is a key signaling factor through which calcium-regulating hormones PTH and PTHrP exert their effects on bone. There are contradictory reports regarding the capability of osteoclasts to express PTH-1R.
M C, Langub, M C, Monier-Faugere, Q, Qi, Z, Geng, N J, Koszewski, H H, Malluche   +5 more
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Autoactivation of Type-1 Parathyroid Hormone Receptors Containing a Tethered Ligand [PDF]

Journal of Biological Chemistry, 2000
Interactions between the N-terminal residues of parathyroid hormone (PTH) and the region of the PTH receptor containing the extracellular loops and transmembrane domains are thought to be critical for receptor activation. We evaluated this hypothesis by replacing the large N-terminal extracellular domain of the human type 1 PTH receptor (hP1Rc-WT) with
M, Shimizu, P H, Carter, T J, Gardella
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Agonist-regulated Cleavage of the Extracellular Domain of Parathyroid Hormone Receptor Type 1 [PDF]

Journal of Biological Chemistry, 2010
The receptor for parathyroid hormone (PTHR) is a main regulator of calcium homeostasis and bone maintenance. As a member of class B of G protein-coupled receptors, it harbors a large extracellular domain, which is required for ligand binding. Here, we demonstrate that the PTHR extracellular domain is cleaved by a protease belonging to the family of ...
Klenk C, Schulz S, Calebiro D, Lohse MJ
openaire   +2 more sources

Parathyroid hormone type 1 receptor regulates osteosarcoma K7M2 Cell growth by interacting with angiotensinogen [PDF]

Journal of Cellular and Molecular Medicine, 2021
AbstractThis study aimed to determine the interactions between parathyroid hormone type 1 receptor (PTHR1) and angiotensinogen (AGT) and the effects of these agents on osteosarcoma (OS). We constructed a stably transfected mouse OS K7M2 cell line (shPTHR1‐ K7M2) using shRNA and knocked down AGT in these cells using siRNA‐AGT.
Shenglong Li, Fei Liu, Yi Pei, Yujin Dong, Yaohua Shang   +4 more
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Inactivating Mutation in the Human Parathyroid Hormone Receptor Type 1 Gene in Blomstrand Chondrodysplasia [PDF]

Endocrinology, 1998
A single homozygous nucleotide exchange in exon E3 of the gene encoding the parathyroid hormone receptor type 1 (PTHR1) was identified in an infant with Blomstrand chondrodysplasia born to consanguineous parents. This alteration changes a strictly conserved proline residue at position 132 in the receptor's amino terminal extracellular domain to leucine.
A C, Karaplis, B, He, M T, Nguyen, I D, Young, D, Semeraro, H, Ozawa, N, Amizuka   +6 more
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Role of Phospholipase D in Parathyroid Hormone Type 1 Receptor Signaling and Trafficking [PDF]

Molecular Endocrinology, 2009
The role of phospholipase D (PLD) in the regulation of the traffic of the PTH type 1 receptor (PTH1R) was studied in Chinese hamster ovary cells stably transfected with a human PTH1R (CHO-R3) and in rat osteosarcoma 17/2.8 (ROS) cells. PTH(1-34) increased total PLD activity by 3-fold in CHO-R3 cells and by 2-fold in ROS cells.
José Luis, Garrido, David, Wheeler, Luis Leiva, Vega, Peter A, Friedman, Guillermo, Romero   +4 more
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Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival [PDF]

Journal of Bone and Mineral Research, 2014
Abstract   Osteocytes have a major role in the control of bone remodeling. Mechanical stimulation decreases osteocyte apoptosis and promotes bone accrual, whereas skeletal unloading is deleterious in both respects. PTH1R ablation or overexpression in osteocytes in mice produces trabecular bone loss or
Marta, Maycas, Juan A, Ardura, Luis F, de Castro, Beatriz, Bravo, Arancha R, Gortázar, Pedro, Esbrit   +5 more
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Performance of the pro-FHH score in a delayed diagnosis of familial hypocalciuric hypercalcemia type-1

Journal of Clinical and Translational Endocrinology Case Reports, 2021
We present a case of a 50-year-old woman with familial hypocalciuric hypercalcemia type 1 (FHH-1) that was missed during an initial evaluation of hypercalcemia in the setting of normal serum parathyroid hormone (PTH), leading to unnecessary ...
Akuffo Quarde, Chris Y. Fan, Jennifer Leonhard   +2 more
doaj   +1 more source