Recent Developments in Parathyroid Hormone Type 1 Receptor and Kidney Disease [PDF]
Zhongguo quanke yixue, 2023 Parathyroid hormone type 1 receptor (PTH1R), a member of the G-protein-coupled receptor family, is extensively expressed in the human body and is involved in various processes such as embryonic development, calcium and phosphorus homeostasis, body ...
YAN Peng, SONG Jianling, FANG Xiangdong
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Long-acting parathyroid hormone receptor agonist rectifies hypocalcemia in autosomal dominant hypocalcemia type 1 mice [PDF]
The Journal of Clinical InvestigationFadil M. Hannan +9 more
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Effect of genetic polymorphisms of aldehyde dehydrogenase 2 on the efficacy of intermittent parathyroid hormone treatment and bone mineral density: A retrospective multicenter study [PDF]
Osteoporosis and SarcopeniaObjectives: In a mouse model, aldehyde dehydrogenase 2 (ALDH2) knockout resulted in lower bone mineral density; however, higher parathyroid hormone receptor expression than wild-type mice.
Hinako Obara +9 more
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BMC Cancer, 2022 Background Parathyroid hormone-related peptide (PTHrP) overexpression and poor patient outcome have been reported for many human tumors, but no studies are available in laryngeal cancer.
Giovanni Almadori +9 more
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Calcitonin values in pseudohypoparathyroidism [PDF]
Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 2023 Pseudohypoparathyroidism type 1A is a rare endocrine disorder caused by GNAS mutation and the resulting hormone resistance at the receptor level, i.e. the activation of the intracellular pathway of the Gs alpha subunit is not possible.
Marković Bojan +6 more
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A variant in the CASR gene (c.368T>C) causing hypocalcemia refractory to standard medical therapy
Endocrinology, Diabetes & Metabolism Case Reports, 2021 Hypoparathyroidism is characterized by low or inappropriately normal parathormone production, hypocalcemia and hyperphosphatemia. Autosomal dominant hypocalcemia (ADH) type 1 is one of the genetic etiologies of hypoparathyroidism caused by heterozygous ...
Diana Festas Silva +7 more
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Autosomal dominant hypocalcemia with a novel mutation: a case study and literature review
Journal of International Medical Research, 2022 Autosomal dominant hypocalcemia type 1 (ADH1) is a rare inherited disorder characterized by hypocalcemia with low parathyroid hormone (PTH) levels and high urinary calcium.
Yingying Wu +5 more
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Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor
Frontiers in Endocrinology, 2022 Parathyroid hormone 1 receptor (PTH1R) is a member of the class B family of G protein-coupled receptors, which are characterized by a large extracellular domain required for ligand binding.
Christoph Klenk +7 more
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Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase
Journal of Pharmacological Sciences, 2021 Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown.
Masaki Saito +5 more
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The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue
Biomolecules, 2021 Adipose tissue is an organ that shows great plasticity and is able to adapt to the conditions to which the body is subdued. It participates in the regulation of energetic homeostasis and has endocrine functions.
Adriana Izquierdo-Lahuerta
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