BMC Cancer, 2022 Background Parathyroid hormone-related peptide (PTHrP) overexpression and poor patient outcome have been reported for many human tumors, but no studies are available in laryngeal cancer.
Giovanni Almadori +9 more
doaj +5 more sources
Parathyroid hormone type 1 receptor regulates osteosarcoma K7M2 Cell growth by interacting with angiotensinogen [PDF]
Journal of Cellular and Molecular Medicine, 2021 This study aimed to determine the interactions between parathyroid hormone type 1 receptor (PTHR1) and angiotensinogen (AGT) and the effects of these agents on osteosarcoma (OS). We constructed a stably transfected mouse OS K7M2 cell line (shPTHR1‐ K7M2)
Shenglong Li +4 more
semanticscholar +3 more sources
Recent Developments in Parathyroid Hormone Type 1 Receptor and Kidney Disease [PDF]
Zhongguo quanke yixue, 2023 Parathyroid hormone type 1 receptor (PTH1R), a member of the G-protein-coupled receptor family, is extensively expressed in the human body and is involved in various processes such as embryonic development, calcium and phosphorus homeostasis, body ...
YAN Peng, SONG Jianling, FANG Xiangdong
doaj +2 more sources
Parathyroid hormone and parathyroid hormone type-1 receptor accelerate myocyte differentiation [PDF]
Scientific Reports, 2014 The ZHTc6-MyoD embryonic stem cell line expresses the myogenic transcriptional factor MyoD under the control of a tetracycline-inducible promoter. Following induction, most of the ZHTc6-MyoD cells differentiate to myotubes. However, a small fraction does
S. Kimura, K. Yoshioka
semanticscholar +3 more sources
Endosomal signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology.
Molecular and Cellular Endocrinology, 2023 Compartmentalization of GPCR signaling is an emerging topic that highlights the physiological relevance of spatial bias in signaling. The parathyroid hormone (PTH) type 1 receptor (PTH1R) was the first GPCR described to signal via heterotrimeric G ...
Karina A. Peña, S. Savransky, B. Lewis
semanticscholar +3 more sources
Selective Ligand-induced Stabilization of Active and Desensitized Parathyroid Hormone Type 1 Receptor Conformations* [PDF]
Journal of Biological Chemistry, 2002 For many G protein-coupled receptors, agonist-induced activation is followed by desensitization, internalization, and resensitization. In most cases, these processes are dependent upon interaction of agonist-occupied receptor with cytoplasmic beta-arrestins.
A. Bisello +5 more
semanticscholar +3 more sources
Parathyroid Hormone/Parathyroid Hormone‐Related Peptide Type 1 Receptor in Human Bone [PDF]
Journal of Bone and Mineral Research, 2001 Abstract The parathyroid hormone/parathyroid hormone-related peptide (PTH/PTHrP) receptor (denoted as PTH-1R) is a key signaling factor through which calcium-regulating hormones PTH and PTHrP exert their effects on bone. There are contradictory reports regarding the capability of osteoclasts to express PTH-1R.
M. Langub +5 more
semanticscholar +3 more sources
Effect of genetic polymorphisms of aldehyde dehydrogenase 2 on the efficacy of intermittent parathyroid hormone treatment and bone mineral density: A retrospective multicenter study [PDF]
Osteoporosis and SarcopeniaObjectives: In a mouse model, aldehyde dehydrogenase 2 (ALDH2) knockout resulted in lower bone mineral density; however, higher parathyroid hormone receptor expression than wild-type mice.
Hinako Obara +9 more
doaj +2 more sources
Beta-arrestin-dependent parathyroid hormone-stimulated extracellular signal-regulated kinase activation and parathyroid hormone type 1 receptor internalization. [PDF]
Endocrinology, 2007 PTH regulates renal calcium homeostasis by actions on the distal nephron. PTH-induced calcium transport in mouse distal convoluted tubule (DCT) cells requires activation of ERK1/2. ERK activation by β-adrenergic receptors occurs in a biphasic manner and involves receptor internalization.
W. Sneddon, P. A. Friedman
semanticscholar +3 more sources
Over‐expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma [PDF]
International Journal of Cancer, 2007 AbstractOsteosarcoma is the most common primary bone malignancy in children and is associated with rapid bone growth. Parathyroid hormone‐related peptide (PTHrP) signaling via parathyroid hormone Type 1 receptor (PTHR1) is important for skeletal development and is involved in bone metastases in other tumors. The aim of this study was to investigate the
Rui Yang +9 more
semanticscholar +3 more sources