Results 21 to 30 of about 77,428 (274)
Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells.
American Journal of Physiology-Cell Physiology, 2009 The molecular mechanisms by which bone cells transduce mechanical stimuli into intracellular biochemical responses have yet to be established. There is evidence that mechanical stimulation acts synergistically with parathyroid hormone PTH(1-34) in mediating bone growth.
Yan‐Liang Zhang +2 more
semanticscholar +4 more sources
Novel mutations in the parathyroid hormone (PTH)/PTH-related peptide receptor type 1 causing Blomstrand osteochondrodysplasia types I and II. [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2007 AbstractContext: The PTH/PTHrP receptor type 1 (PTHR1) has a key role in endochondral ossification, which is emphasized by diseases resulting from mutations in the PTHR1 gene. Among these diseases is Blomstrand osteochondrodysplasia (BOCD).Objective: BOCD can be divided into two types, depending on the severity of the skeletal abnormalities.
J. Hoogendam +5 more
semanticscholar +3 more sources
Journal of Cellular PhysiologyCaveolin‐1 (Cav1), a protein present in lipid raft invaginations known as caveolae, regulates the trafficking and signaling of some cell surface receptors. Current evidence suggests that the number of caveolae might increase with aging.
Sara Heredero-Jiménez +7 more
semanticscholar +2 more sources
Proceedings of the National Academy of SciencesSignificance We examined how the interaction of the peptide ligand parathyroid hormone (PTH) and its receptor (PTH1R) varies depending on receptor coupling to Gs or Gq.
Xuan Zhang +12 more
semanticscholar +3 more sources
Type 1 Parathyroid Hormone Receptor (PTH1R) Nuclear Trafficking: Association of PTH1R with Importin α1 and β [PDF]
Endocrinology, 2006 Previous studies have shown that the type 1 PTH receptor (PTH1R), a class B G protein-coupled receptor, appears in the nucleus of target cells. Through immunofluorescence and deconvolution microscopy, we demonstrate that PTH1R, importin alpha(1), and importin beta are present within the nucleus and cytoplasm of osteoblast-like cell lines with the ...
B. Pickard +3 more
semanticscholar +3 more sources
Parathyroid Hormone Type 1 Receptor and Human Osteoclasts [PDF]
Journal of Bone and Mineral Research, 2002 M. Langub, H. Malluche
semanticscholar +2 more sources
Calcitonin values in pseudohypoparathyroidism [PDF]
Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 2023 Pseudohypoparathyroidism type 1A is a rare endocrine disorder caused by GNAS mutation and the resulting hormone resistance at the receptor level, i.e. the activation of the intracellular pathway of the Gs alpha subunit is not possible.
Marković Bojan +6 more
doaj +1 more source
The Unicellular State as a Point Source in a Quantum Biological System. [PDF]
, 2016 A point source is the central and most important point or place for any group of cohering phenomena. Evolutionary development presumes that biological processes are sequentially linked, but neither directed from, nor centralized within, any specific ...
Miller, William B, Torday, John S
core +9 more sources
Journal of the Endocrine Society, 2022 Hypercalcemia is a common disorder defined as a serum calcium concentration higher than the normal range of 8.5 - 10.5 mg/dL. The most common causes of hypercalcemia are over-secretion of parathyroid hormone (PTH) from one or more enlarged parathyroid ...
Elizabeth Rico-Bautista +12 more
semanticscholar +1 more source
A variant in the CASR gene (c.368T>C) causing hypocalcemia refractory to standard medical therapy
Endocrinology, Diabetes & Metabolism Case Reports, 2021 Hypoparathyroidism is characterized by low or inappropriately normal parathormone production, hypocalcemia and hyperphosphatemia. Autosomal dominant hypocalcemia (ADH) type 1 is one of the genetic etiologies of hypoparathyroidism caused by heterozygous ...
Diana Festas Silva +7 more
doaj +1 more source