Results 61 to 70 of about 77,428 (274)

Experimental hyperthyroidism increases expression of parathyroid hormone‐related peptide and type‐1 parathyroid hormone receptor in rat ventricular myocardium of the Langendorff ischaemia–reperfusion model [PDF]

Experimental Physiology, 2007
Parathyroid hormone‐related peptide (PTHrP) is released under ischaemic conditions and it improves contractile function of stunned myocardium. The actions of PTHrP are mediated primarily by the type 1 parathyroid hormone receptor (PTH.1R), while PTHrP and PTH.1R expression levels are increased in ventricular hypertrophy associated with experimental ...
Halapas, A., Lembessis, P., Mourouzis, I., Pantos, C., Cokkinos, D.V., Sourla, A., Koutsilieris, M.   +6 more
openaire   +3 more sources

Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with paricalcitol and cinacalcet [PDF]

, 2017
Bone changes related to diabetes have been well stablished, but few strategies have been developed to prevent this growing health problem. In our work, we propose to investigate the effects of calcitriol as well as of a vitamin D analog (paricalcitol ...
Alvarez, Andress, Bergua, Bucking, Chan, Chen, Coyne, Coyne, Coyne, Craig, Cunha, Del Pino-Montes, Devaskar, Elder, Fishbane, Flanagan, Gagnon, Gavaia, Gehling, Goodman, Hamann, Hills, Illien-Junger, Irwin, Jayanarayanan, Jones, Katsumata, Keller, King, Kojima, Kojima, Kojima, Krul-Poel, Lee, Lehner, Lieschke, Lin, Maehata, Moss, Olsen, Pham-Short, Pipino, Pisharath, Pugliese, Rodriguez, Sanguineti, Schutter, Shoben, Sprague, Tsuruta, Tung, Westerfield, Wong, Zhao   +53 more
core   +1 more source

Selective and Nonselective Inverse Agonists for Constitutively Active Type-1 Parathyroid Hormone Receptors: Evidence for Altered Receptor Conformations* [PDF]

Endocrinology, 2001
The spontaneous signaling activity of some G protein-coupled receptors and the capacity of certain ligands (inverse agonists) to inhibit such constitutive activity are poorly understood phenomena. We investigated these processes for several analogs of PTH-related peptide (PTHrP) and the constitutively active human PTH/PTHrP receptors (hP1Rcs) hP1Rc ...
P H, Carter, B D, Petroni, R C, Gensure, E, Schipani, J T, Potts , T J, Gardella   +5 more
openaire   +2 more sources

Treatment of Hypoparathyroidism by Re-Establishing the Effects of Parathyroid Hormone [PDF]

Endocrinology and Metabolism
The conventional treatment of hypoparathyroidism (HypoPT) includes active vitamin D and calcium. Despite normalization of calcium levels, the conventional treatment is associated with fluctuations in calcium levels, hypercalciuria, renal impairment, and ...
Lars Rejnmark
doaj   +1 more source

Coronectomy of deeply impacted lower third molar : incidence of outcomes and complications after one year follow-up [PDF]

, 2015
Objectives: The purpose of present study was to assess the surgical management of impacted third molar with proximity to the inferior alveolar nerve and complications associated with coronectomy in a series of patients undergoing third molar surgery ...
Ajbage, Jimoh Olubanwo, Heijsters, Guido, Politis, Constantinus, Salem, Ahmed Sobhy, Schepers, Serge, Van Slycke, Sarah, Vrielinck, Luc   +6 more
core   +3 more sources

Human diseases caused by homozygous PTH1R mutations

Frontiers in Endocrinology
The parathyroid hormone receptor type 1 (PTH1R) is a G protein-coupled receptor that mediates the actions of parathyroid hormone (PTH) in the regulation of blood calcium levels, as well as PTH-related protein (PTHrP) in the regulation of skeletal ...
Ignacio Portales-Castillo, Jakob Höppner, Harald Jüppner, Harald Jüppner, Thomas J. Gardella   +4 more
doaj   +1 more source

Thyroxine-binding globulin: investigation of microheterogeneity [PDF]

, 1981
Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland, Henze, R., Horn, K., Pickardt, C. R., Scriba, Peter Christian   +4 more
core   +1 more source

Hypercalcemia in the setting of HTLV-1 infection and a normal PTHrP level

Endocrinology, Diabetes & Metabolism Case Reports, 2022
Human T-cell lymphotropic virus-1 (HTLV-1) causes adult T-cell leukemia and lymphoma (ATLL) and is a rare but important cause of hypercalcemia. A 53-year-old male with HTLV-1-associated myelopathy presented with acute on chronic bilateral lower extremity
Keerthana Haridas
doaj   +1 more source

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level. [PDF]

, 2020
The interest in vitamin D continues unabated with thousands of publications contributing to a vast and growing literature each year. It is widely recognized that the vitamin D receptor (VDR) and the enzymes that metabolize vitamin D are found in many ...
Bikle, Daniel D
core   +1 more source