Results 81 to 90 of about 29,683 (216)

Calcium-sensing receptor autoantibody-mediated hypoparathyroidism associated with immune checkpoint inhibitor therapy: diagnosis and long-term follow-up

Journal for ImmunoTherapy of Cancer, 2020
Background Immune checkpoint inhibitors (ICIs) have produced significant survival benefit across many tumor types. However, immune-related adverse events are common including autoimmune responses against different endocrine organs.
Sapna Patel, Hussein Tawbi, Ramona Dadu, Van A Trinh, Theresa E Rodgers, Elizabeth Helen Kemp, Trisha D Cubb, Julie M Simon, Elizabeth M Burton   +8 more
doaj   +1 more source

Papillary Thyroid Cancer With Cutaneous Metastasis: A Case Report and Literature Review

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cutaneous metastasis of papillary thyroid carcinoma is rare, which may present as slowly growing nodules, erythematous papules, or ulcerative nodules. The pathophysiological mechanisms of skin metastasis in thyroid cancer remain unclear.
Yi‐Qing Gao, Xin‐Lu Yin, Lu‐Ying Zheng, Jia‐Dong Wang   +3 more
wiley   +1 more source

A RARE HEREDITARY DISEASE: PSEUDOHIPOPARATHERIOSIS TYPE 1a IN THE PRACTICE OF A PEDIATRIC ENDOCRINOLOGIST

Мать и дитя в Кузбассе, 2022
Pseudohypoparathyroidism (PGP) is a rare hereditary disease characterized by clinical and laboratory signs of hypoparathyroidism against the background of an increased level of parathyroid hormone (PTH) in the blood.
Алла Дмитриевна Алексеева, Наталья Александровна Жданова, Ирина Владимировна Болгова, Светлана Ивановна Елгина, Вадим Гельевич Мозес, Елена Владимировна Рудаева, Кира Борисовна Мозес, Яэль Центер   +7 more
doaj  

Understanding Low Motivation for Treatment in Primary Hyperparathyroidism: A Qualitative Study of Patients and Providers in the United States

World Journal of Surgery, EarlyView.
Untreated PHPT represents a major health service failure driven in part by poor disease literacy and constrained primary care encounters. ABSTRACT Background Two thirds of patients with primary hyperparathyroidism (PHPT) go untreated, risking progressive osteoporosis, fractures, and nephrolithiasis.
John O'Connor, Alexandra Helbing, Diana Guiterrez‐Meza, Esra Alagoz, Alexander Chiu   +4 more
wiley   +1 more source

Deletion of the nuclear localization sequences and C-terminus of PTHrP impairs embryonic mammary development but also inhibits PTHrP production.

PLoS ONE, 2014
Parathyroid hormone-related protein (PTHrP) can be secreted from cells and interact with its receptor, the Type 1 PTH/PTHrP Receptor (PTHR1) in an autocrine, paracrine or endocrine fashion.
Kata Boras-Granic, Pamela Dann, Joshua Vanhouten, Andrew Karaplis, John Wysolmerski   +4 more
doaj   +1 more source

Key Interaction Changes Determine the Activation Process of Human Parathyroid Hormone Type 1 Receptor

Journal of the American Chemical Society
The parathyroid hormone type 1 receptor (PTH1R) plays a crucial role in modulating various physiological functions and is considered an effective therapeutic target for osteoporosis. However, a lack of detailed molecular and energetic information about PTH1R limits our comprehensive understanding of its activation process.
Yue Zhang, Qingchuan Zheng, Arieh Warshel, Chen Bai   +3 more
openaire   +2 more sources

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes

BMC Genetics, 2004
Background The adequacy of association studies for complex diseases depends critically on the existence of linkage disequilibrium (LD) between functional alleles and surrounding SNP markers.
Shen Hui, Dvornyk Volodymyr, Lu Yan, Liu Peng-Yuan, Zhao Lan-Juan, Long Ji-Rong, Liu Yong-Jun, Zhang Yuan-Yuan, Xiong Dong-Hai, Xiao Peng, Deng Hong-Wen   +10 more
doaj   +1 more source

Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer

Cancer Science, EarlyView.
Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang, Tianli Zhang, Xue Kong, Yao Tong, Yanru Li, Xiangjun Dong, Chuanxin Wang, Juan Li   +7 more
wiley   +1 more source

Mechanisms Underpinning Adaptations in Placental Calcium Transport in Normal Mice and Those With Fetal Growth Restriction

Frontiers in Endocrinology, 2018
Fetal delivery of calcium, via the placenta, is crucial for appropriate skeletal mineralization. We have previously demonstrated that maternofetal calcium transport, per gram placenta, is increased in the placental specific insulin-like growth factor 2 ...
Christina E. Hayward, Christina E. Hayward, Kirsty R. McIntyre, Kirsty R. McIntyre, Colin P. Sibley, Colin P. Sibley, Susan L. Greenwood, Susan L. Greenwood, Mark R. Dilworth, Mark R. Dilworth   +9 more
doaj   +1 more source