Results 101 to 110 of about 79,696 (126)

Somatic Platelet Derived Growth Factor Receptor Beta Activating Variants in Fusiform Cerebral Aneurysms [PDF]

Neurosurgery, 2019
Joshua W. Osbun, Tina Busald, Diana Alcantra, Philip D. Tatman, Yigit Karasozen, Louis J. Kim, Peter H. Byers, Mitzi L. Murray, Christopher J. Hale, Michael O. Dorschner, Manuel A. R. Ferreira, Luis F. Gonzalez-Cuyar, William B. Dobyns, Mark O'Driscoll, Carolina Parada   +14 more
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The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1

Molecular and Cellular Biology, 1995
M. Valius, J. Secrist, A. Kazlauskas
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Platelet-derived Growth Factor Receptor-beta is Differentially Regulated in Primary Mouse Pericytes and Brain Slices

Current Neurovascular Research, 2016
Pericytes are perivascular cells and have heterogenous roles in the brain, such as controlling blood flow and entry of immune cells or regulating the blood-brain barrier. Platelet-derived growth factor (PDGF) receptor-beta (PDGFRβ) is highly expressed in pericytes, representing the most selective biomarker.
Christian Humpel, Bianca Hutter-Schmid
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Mechanism of action and in vivo role of platelet-derived growth factor.

Physiological Reviews, 1999
Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally similar A- and B-polypeptide chains, which combine to homo- and ...
C. Heldin, B. Westermark
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Association of Coatomer Proteins with the β-Receptor for Platelet-Derived Growth Factor

Biochemical and Biophysical Research Communications, 1997
The nonreceptor tyrosine kinase Src binds to and is activated by the beta-receptor for platelet-derived growth factor (PDGF). The interaction leads to Src phosphorylation of Tyr934 in the kinase domain of the receptor. In the course of the functional characterization of this phosphorylation, we noticed that components of 136 and 97 kDa bound to a ...
Hansen, Klaus, Rönnstrand, L, Rorsman, C, Hellman, U, Heldin, C H   +4 more
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Regulation of chemotaxis by the platelet-derived growth factor receptor-β

Nature, 1994
Chemotaxis is an important component of wound healing, development, immunity and metastasis, yet the signalling pathways that mediate chemotaxis are poorly understood. Platelet-derived growth factor (PDGF) acts both as a mitogen and a chemoattractant. Upon stimulation, the tyrosine kinase PDGF receptor-beta (PDGFR-beta) autophosphorylates and forms a ...
Sue Goo Rhee, Vikas Kundra, Bruce R. Zetter, Jaime Escobedo, Ha Kun Kim, Lewis T. Williams, Andrius Kazlauskas   +6 more
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Transforming growth factor beta 1 downregulates the platelet-derived growth factor alpha-receptor subtype on human lung fibroblasts in vitro.

American Journal of Respiratory Cell and Molecular Biology, 1995
Fibroblasts are the central target cell in pulmonary fibrotic diseases, and their proliferation is mediated largely by platelet-derived growth factor (PDGF) isoforms secreted by activated lung macrophages.
J. Bonner, A. Badgett, P. Lindroos, Álvaro R. Osornio-Vargas   +3 more
semanticscholar   +1 more source

Platelet-Derived Growth Factor-Receptor-β in Pig and Cattle Blastocysts

Cells Tissues Organs, 1997
Presence and localization of the platelet-derived growth factor-receptor-β (PDGF-Rβ) was investigated in preimplantation bovine and porcine embryos. Blastocyst stages before and at the time of elongation were chosen, i.e. 9- to 13-day-old pig blastocysts and 14- to 16-day-old cattle blastocysts.
E. Kim, B. Fischer
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Expression of platelet-derived growth factor B-chain and platelet-derived growth factor β-receptor in fibroblasts of scleroderma

Journal of Dermatological Science, 1998
Scleroderma is a fibrotic disease occurring in a localized or systemic form. The pathogenesis of scleroderma remains poorly understood. Recent studies revealed that various cytokines and growth factors were involved in the development of scleroderma fibrosis.
Zhang Jian-zhong, Ping Tu, Shengqing Ma, Zheng Xueyi   +3 more
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Enhanced Expression of Platelet-Derived Growth Factor-β Receptor by High Glucose Involvement of Platelet-Derived Growth Factor in Diabetic Angiopathy

Diabetes, 1996
Coronary heart disease is a major complication of diabetic subjects, and platelet-derived growth factor (PDGF) has been implicated in the development of atherosclerosis. We investigated the effects of high glucose on expression of PDGF-β receptor. In a binding assay with 125I-labeled PDGF-BB homodimer, high concentrations of glucose increased high ...
Noritsugu Morino, Yoshio Yazaki, Toshimori Inaba, Masanobu Kawakami, N. Yamada, Takanari Gotoda, Shun Ishibashi, Yoshihisa Nojima, Masako Kawamura   +8 more
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