Results 101 to 110 of about 144,656 (207)

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Best, A.K., Columbus, L., Dunn, C.A., Isakson, B.E., Johnstone, S.R., Koval, M., Kroncke, B.M., Lampe, P.D., Lo, C.W., Mitchell, L.A., Nakamoto, R.K., Peskova, Y., Straub, A.C.   +12 more
core   +1 more source

Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy

Frontiers in Molecular Biosciences
Platelet-derived growth factor receptor beta (PDGFRβ) belongs to the receptor tyrosine kinase (RTK) protein family and is implicated in several disorders such as hematopoietic, glial, and soft-tissue cancer, non-cancerous disorders, including skeletal ...
Insan Habib, Insan Habib, Md Nayab Sulaimani, Deeba Shamim Jairajpuri, Afzal Hussain, Taj Mohammad, Mohamed F. Alajmi, Anas Shamsi, Md Imtaiyaz Hassan   +8 more
doaj   +1 more source

Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach

Journal of Diabetes Research, 2014
We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets and candidate agents for T2D treatment. The differentially expressed genes (DEGs) were assessed between human pancreatic islets with T2D and normal ...
Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia   +3 more
doaj   +1 more source

Transcriptional Regulation ofthe Platelet-Derived Growth Factor beta-receptor

, 2004
The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses such as differentiation and cell movement.
openaire  

Immune thrombocytopenia is associated with persistently deranged fibrosis-related seromarker profiles but low bone marrow fibrosis grades: A 2-year observational study on thrombopoietin receptor agonist treatment

Platelets, 2019
Bone marrow (BM) fibrosis is a potential side effect of thrombopoietin receptor agonist (TPO-RA) treatment. We aimed to investigate stromal seromarker profiles and growth factors in order to elucidate pathogenic and dynamic aspects of immune ...
Waleed Ghanima, Leonardo Boiocchi, Christina S. Lee, Xingmin Feng, Julia Turbiner Geyer, Sif Gudbrandsdottir, Attilio Orazi, Peter Junker, James B. Bussel   +8 more
doaj   +1 more source

Infantile myofibromatosis and capillary malformation of the skin due to PDGFRB mosaicism

Molecular and Cellular Pediatrics
This report describes the case of a 25-year-old female patient with multicentric infantile myofibromatosis since early infancy, superficial capillary malformations and congenital hypoplasia of the third and fourth finger of her right hand.
Luise Pudig, Silke Lassmann, Sebastian Jacob, Marina Nastainczyk-Wulf, Anja Haak, Martin Werner, Friedrich G Kapp, Simone Hettmer   +7 more
doaj   +1 more source

Profile of pazopanib and its potential in the treatment of epithelial ovarian cancer

International Journal of Women's Health, 2014
Brittany A Davidson, Angeles Alvarez Secord Division of Gynecologic Oncology, Duke Cancer Institute, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA Abstract: Epithelial ovarian cancer (EOC) is the most lethal ...
Davidson BA, Secord AA
doaj  

Investigation of a 47Sc-radiolabelled PDGFRβ-targeted affibody in SPECT imaging and radiotherapy for pancreatic cancer

BMC Cancer
Pancreatic cancer is a malignant solid tumour that contains a large number of cancer-associated fibroblasts (CAFs). Therefore, evaluating tumour disease progression and planning radionuclide therapy using molecular imaging of CAF biomarkers are crucial ...
Ruomeng Liu, Dongping Su, Yuhao Liao, Zhao Li, Bo Li, Yunming Chen, Qi Cao, Jinsong Zhang, Huawei Cai   +8 more
doaj   +1 more source

Platelet-Derived Growth Factor Receptor Beta [PDF]

, 2020
openaire   +1 more source

Biogenesis of Organelles and Membrane Proteins. [PDF]

, 1988
Harmey, Matthew A., Neupert, Walter, Nicholson, Donald W., Stuart, Rosemary A.   +3 more
core   +1 more source