Results 111 to 120 of about 79,696 (126)
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Biochemistry, 1992
In an effort to biochemically characterize PDGF receptors and their mechanism of activation, recombinant baculovirus vectors containing the cDNAs of the human alpha PDGF receptor or beta PDGF receptor were engineered. Characterization of recombinant PDGF receptor expression in infected Sf9 insect cells by immunoblot analysis with specific PDGF receptor
William J. LaRochelle +3 more
openaire +2 more sources
In an effort to biochemically characterize PDGF receptors and their mechanism of activation, recombinant baculovirus vectors containing the cDNAs of the human alpha PDGF receptor or beta PDGF receptor were engineered. Characterization of recombinant PDGF receptor expression in infected Sf9 insect cells by immunoblot analysis with specific PDGF receptor
William J. LaRochelle +3 more
openaire +2 more sources
Dysregulation of Platelet-Derived Growth Factor β-Receptor Expression by ΔNp73 in Neuroblastoma [PDF]
Molecular Cancer Research, 2009 Abstract We have previously characterized how p53 family proteins control the transcriptional regulation of the platelet-derived growth factor β-receptor (PDGFRB) and found that ΔNp73α, acting dominant-negatively to p53 and p73, can upregulate PDGFRB promoter activity.
Abtin Moshiri +5 more
openaire +2 more sources
Cellular Signalling, 2013
In the absence of ligand, certain growth factor receptors can be activated via G-protein coupled receptor (GPCR) activation in a process termed transactivation. Serotonin (5-HT) receptors can transactivate platelet-derived growth factor (PDGF) β receptors in smooth muscle cells, but it is not known if similar pathways occur in neuronal cells.
John J. Heikkila +4 more
openaire +3 more sources
In the absence of ligand, certain growth factor receptors can be activated via G-protein coupled receptor (GPCR) activation in a process termed transactivation. Serotonin (5-HT) receptors can transactivate platelet-derived growth factor (PDGF) β receptors in smooth muscle cells, but it is not known if similar pathways occur in neuronal cells.
John J. Heikkila +4 more
openaire +3 more sources
Arthritis & Rheumatism, 2000
OBJECTIVE Abnormalities of transforming growth factor beta (TGFbeta) and platelet-derived growth factor (PDGF) alpha and beta and/or their receptors have been demonstrated in systemic sclerosis (SSc).
Xiaodong Zhou +3 more
semanticscholar +1 more source
OBJECTIVE Abnormalities of transforming growth factor beta (TGFbeta) and platelet-derived growth factor (PDGF) alpha and beta and/or their receptors have been demonstrated in systemic sclerosis (SSc).
Xiaodong Zhou +3 more
semanticscholar +1 more source
Biochemistry, 1997
The mechanism of action of AG1296, a potent and specific inhibitor of the platelet-derived growth factor (PDGF) receptor tyrosine kinase [Kovalenko, M., Gazit, A., Böhmer, A., Rorsman, Ch., Rönnstrand, L., Heldin, C.-H., Waltenberger, J., Böhmer, F. D., &
M. Kovalenko +6 more
semanticscholar +1 more source
The mechanism of action of AG1296, a potent and specific inhibitor of the platelet-derived growth factor (PDGF) receptor tyrosine kinase [Kovalenko, M., Gazit, A., Böhmer, A., Rorsman, Ch., Rönnstrand, L., Heldin, C.-H., Waltenberger, J., Böhmer, F. D., &
M. Kovalenko +6 more
semanticscholar +1 more source
Acta Haematologica, 2002
Acquired reciprocal chromosomal translocations that involve chromosome bands 5q31–33 are associated with a significant minority of patients with <i>BCR-ABL-</i>negative chronic myeloid leukemias. The most common abnormality is the t(5;12)(q33;p13), which fuses the <i>ETV6/TEL</i> gene to the platelet-derived growth factor ...
Steer, E.J., Cross, N.C.
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Acquired reciprocal chromosomal translocations that involve chromosome bands 5q31–33 are associated with a significant minority of patients with <i>BCR-ABL-</i>negative chronic myeloid leukemias. The most common abnormality is the t(5;12)(q33;p13), which fuses the <i>ETV6/TEL</i> gene to the platelet-derived growth factor ...
Steer, E.J., Cross, N.C.
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Blood, 1998
We report the fusion of the Huntingtin interactin protein 1 (HIP1) gene to the platelet-derived growth factor betareceptor (PDGFbetaR) gene in a patient with chronic myelomonocytic leukemia (CMML) with a t(5;7)(q33;q11.2) translocation.
T. Ross +3 more
semanticscholar +1 more source
We report the fusion of the Huntingtin interactin protein 1 (HIP1) gene to the platelet-derived growth factor betareceptor (PDGFbetaR) gene in a patient with chronic myelomonocytic leukemia (CMML) with a t(5;7)(q33;q11.2) translocation.
T. Ross +3 more
semanticscholar +1 more source
Differential Chemotactic Responses Mediated by Platelet-Derived Growth-Factor α- and β-Receptors
Archives of Biochemistry and Biophysics, 1995We have performed a modified Boyden chamber chemotaxis assay using NRK-49F cells under serum-free condition, in order to characterize the chemotactic activity of recombinant platelet-derived growth factor (PDGF)-AA, -AB, and -BB. All three PDGF isoforms showed similar chemotactic activity on NRK cells expressing both PDGF alpha- and beta-receptors.
Nobuhiro Hayashi, Y Soma, K Takehara
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Expression of functional β-platelet-derived growth factor receptors on hematopoietic cell lines
Cytokine, 1993The beta-type receptor of platelet-derived growth factor (beta PDGFR) is a class III transmembrane receptor with tyrosine kinase activity. The beta PDGFR gene is located on mouse chromosome 18 close to the c-fms gene which codes for the colony stimulating factor-1 receptor (CSF-1R).
de Parseval, N +4 more
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Blood, 2008
To the editor: Erdheim-Chester disease (ECD) is a non-Langerhans form of CD68+ CD1a− histiocytosis.[1][1][⇓][2][⇓][3]–[4][4] Interferon α (IFNα) is effective in ECD.[3][3],[5][5] Efficacy is however depending on the site of involvement.
Carlos Graux +7 more
openaire +3 more sources
To the editor: Erdheim-Chester disease (ECD) is a non-Langerhans form of CD68+ CD1a− histiocytosis.[1][1][⇓][2][⇓][3]–[4][4] Interferon α (IFNα) is effective in ECD.[3][3],[5][5] Efficacy is however depending on the site of involvement.
Carlos Graux +7 more
openaire +3 more sources