Results 171 to 180 of about 144,656 (207)
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Journal of Dermatological Science, 1998
Scleroderma is a fibrotic disease occurring in a localized or systemic form. The pathogenesis of scleroderma remains poorly understood. Recent studies revealed that various cytokines and growth factors were involved in the development of scleroderma fibrosis.
X Y, Zheng, J Z, Zhang, P, Tu, S Q, Ma
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Scleroderma is a fibrotic disease occurring in a localized or systemic form. The pathogenesis of scleroderma remains poorly understood. Recent studies revealed that various cytokines and growth factors were involved in the development of scleroderma fibrosis.
X Y, Zheng, J Z, Zhang, P, Tu, S Q, Ma
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Blood, 2008
To the editor: Erdheim-Chester disease (ECD) is a non-Langerhans form of CD68+ CD1a− histiocytosis.[1][1][⇓][2][⇓][3]–[4][4] Interferon α (IFNα) is effective in ECD.[3][3],[5][5] Efficacy is however depending on the site of involvement.
Julien, Haroche +7 more
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To the editor: Erdheim-Chester disease (ECD) is a non-Langerhans form of CD68+ CD1a− histiocytosis.[1][1][⇓][2][⇓][3]–[4][4] Interferon α (IFNα) is effective in ECD.[3][3],[5][5] Efficacy is however depending on the site of involvement.
Julien, Haroche +7 more
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Biochemistry, 1992
In an effort to biochemically characterize PDGF receptors and their mechanism of activation, recombinant baculovirus vectors containing the cDNAs of the human alpha PDGF receptor or beta PDGF receptor were engineered. Characterization of recombinant PDGF receptor expression in infected Sf9 insect cells by immunoblot analysis with specific PDGF receptor
R A, Jensen +3 more
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In an effort to biochemically characterize PDGF receptors and their mechanism of activation, recombinant baculovirus vectors containing the cDNAs of the human alpha PDGF receptor or beta PDGF receptor were engineered. Characterization of recombinant PDGF receptor expression in infected Sf9 insect cells by immunoblot analysis with specific PDGF receptor
R A, Jensen +3 more
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Expression of functional β-platelet-derived growth factor receptors on hematopoietic cell lines
Cytokine, 1993The beta-type receptor of platelet-derived growth factor (beta PDGFR) is a class III transmembrane receptor with tyrosine kinase activity. The beta PDGFR gene is located on mouse chromosome 18 close to the c-fms gene which codes for the colony stimulating factor-1 receptor (CSF-1R).
de Parseval, N +4 more
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The Journal of Immunology, 1993
Abstract Platelet-derived growth factor (PDGF) is thought to play a significant role in bone repair and regeneration. We previously demonstrated that PDGF-AA-induced chemotaxis and proliferation can be modulated by IL-1. We now report that IL-1 and transforming growth factor-beta (TGF-beta) significantly decrease the number of PDGF-AA ...
Y L, Yeh +4 more
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Abstract Platelet-derived growth factor (PDGF) is thought to play a significant role in bone repair and regeneration. We previously demonstrated that PDGF-AA-induced chemotaxis and proliferation can be modulated by IL-1. We now report that IL-1 and transforming growth factor-beta (TGF-beta) significantly decrease the number of PDGF-AA ...
Y L, Yeh +4 more
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Cellular Signalling, 2013
In the absence of ligand, certain growth factor receptors can be activated via G-protein coupled receptor (GPCR) activation in a process termed transactivation. Serotonin (5-HT) receptors can transactivate platelet-derived growth factor (PDGF) β receptors in smooth muscle cells, but it is not known if similar pathways occur in neuronal cells.
Jeff S, Kruk +4 more
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In the absence of ligand, certain growth factor receptors can be activated via G-protein coupled receptor (GPCR) activation in a process termed transactivation. Serotonin (5-HT) receptors can transactivate platelet-derived growth factor (PDGF) β receptors in smooth muscle cells, but it is not known if similar pathways occur in neuronal cells.
Jeff S, Kruk +4 more
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Association of Coatomer Proteins with the β-Receptor for Platelet-Derived Growth Factor
Biochemical and Biophysical Research Communications, 1997The nonreceptor tyrosine kinase Src binds to and is activated by the beta-receptor for platelet-derived growth factor (PDGF). The interaction leads to Src phosphorylation of Tyr934 in the kinase domain of the receptor. In the course of the functional characterization of this phosphorylation, we noticed that components of 136 and 97 kDa bound to a ...
Hansen, Klaus +4 more
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Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, 1995
An experimental study was done in two rabbits to establish whether the early stages of cartilage generation involves stimulation via the platelet-derived growth factor beta receptor (PDGFR-beta). Rib perichondrium was dissected off and transplanted to the knee joint. The perichondrial grafts were removed for microscopic investigation at day 0 and day 6
A, Ljung +5 more
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An experimental study was done in two rabbits to establish whether the early stages of cartilage generation involves stimulation via the platelet-derived growth factor beta receptor (PDGFR-beta). Rib perichondrium was dissected off and transplanted to the knee joint. The perichondrial grafts were removed for microscopic investigation at day 0 and day 6
A, Ljung +5 more
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Experimental Cell Research, 1999
The platelet-derived growth factor beta receptor (betaPDGFR) is a receptor tyrosine kinase involved in multiple aspects of cell growth and differentiation. Upon activation, betaPDGFR is phosphorylated at up to nine different tyrosine residues. Phosphorylation of the receptor results in at least two different outcomes: recruitment of signaling molecules
A, Bernard, A, Kazlauskas
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The platelet-derived growth factor beta receptor (betaPDGFR) is a receptor tyrosine kinase involved in multiple aspects of cell growth and differentiation. Upon activation, betaPDGFR is phosphorylated at up to nine different tyrosine residues. Phosphorylation of the receptor results in at least two different outcomes: recruitment of signaling molecules
A, Bernard, A, Kazlauskas
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Differential Chemotactic Responses Mediated by Platelet-Derived Growth-Factor α- and β-Receptors
Archives of Biochemistry and Biophysics, 1995We have performed a modified Boyden chamber chemotaxis assay using NRK-49F cells under serum-free condition, in order to characterize the chemotactic activity of recombinant platelet-derived growth factor (PDGF)-AA, -AB, and -BB. All three PDGF isoforms showed similar chemotactic activity on NRK cells expressing both PDGF alpha- and beta-receptors.
N, Hayashi, K, Takehara, Y, Soma
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