Results 11 to 20 of about 144,656 (207)
Mitigative effects of Otilonium Bromide on methotrexate-induced hepatic damage in rats [PDF]
BMC Research NotesObjective Hepatotoxicity is a significant adverse effect associated with long-term methotrexate (MTX) treatment, limiting its clinical utility. This study aimed to comprehensively evaluate the potential hepatoprotective effects of Otilonium Bromide (OB ...
Murat Arı +2 more
doaj +2 more sources
Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling. [PDF]
PLoS ONE, 2008 Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation ...
Maria Arantzazu Sanchez-Fernandez +4 more
doaj +1 more source
Stromal expression of platelet-derived growth factor beta-receptor and platelet-derived growth factor B-chain in colorectal cancer. [PDF]
Laboratory investigation; a journal of technical methods and pathology, 1994 The importance of growth factors, such as platelet-derived growth factor (PDGF), for stromal activation in colorectal cancer is unclear.The expression of beta-receptors for PDGF, and PDGF B-chain (PDGF AB and PDGF BB) was investigated by immunohistologic techniques in full-thickness biopsies from 210 colorectal cancers.
G, Lindmark +5 more
openaire +4 more sources
Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells [PDF]
Oncogene, 2003 The Ewing's sarcoma family of tumors (ESFT) contain a translocation, t(11;22), which results in the novel oncogenic fusion protein EWS/FLI1. Platelet-derived growth factors (PDGF) and their receptors (PDGFR) are involved in the induction and proliferation of numerous solid tumors and are the potential candidates for novel targeted antitumor therapy ...
A, Uren +10 more
openaire +2 more sources
Anatolian Journal of Cardiology, 2020 Objective: Microvascular angina (MVA) is a coronary microcirculation disease. Research on microcirculatory dysfunction has revealed several biomarkers involved in the etiopathogenesis of MVA.
Gamze Aslan +5 more
doaj +1 more source
Indian Journal of Medical and Paediatric Oncology, 2020 Eosinophilia is a common finding in the pediatric age group. While the majority of mild eosinophilia cases are benign and due to reactive causes, persistent hypereosinophilia is uncommon and requires prompt clinical evaluation because of the potential ...
Abdul Wajid Moothedath +4 more
doaj +1 more source
Probing the Effects of the FGFR-Inhibitor Derazantinib on Vascular Development in Zebrafish Embryos
Pharmaceuticals, 2020 Angiogenesis is a fundamental developmental process and a hallmark of cancer progression. Receptor tyrosine kinases (RTK) are targets for cancer therapy which may include their action as anti-angiogenic agents.
Maria P. Kotini +4 more
doaj +1 more source
Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]
, 2008 Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad +4 more
core +1 more source
The Pericytic Phenotype of Adipose Tissue-Derived Stromal Cells Is Promoted by NOTCH2 [PDF]
, 2017 Long-term diabetes leads to macrovascular and microvascular complication. In diabetic retinopathy (DR), persistent hyperglycemia causes permanent loss of retinal pericytes and aberrant proliferation of microvascular endothelial cells (ECs).
Burgess, Janette Kay +4 more
core +5 more sources
PDGFRB (platelet-derived growth factor receptor, beta polypeptide) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on PDGFRB (platelet-derived growth factor receptor, beta polypeptide), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +1 more source