Results 21 to 30 of about 144,656 (207)

Clinical Benefit of Pazopanib in a Patient with Metastatic Chondrosarcoma: A Case Report and Review of the Literature

open access: yesFrontiers in Oncology, 2018
Chondrosarcoma is a rare malignancy characterized by the production of cartilage matrix, displaying heterogeneous histopathology and clinical behavior.
Onoufrios Tsavaris   +7 more
doaj   +1 more source

Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis. [PDF]

open access: yes, 2010
The most severe clinical and pathologic manifestations of systemic sclerosis (SSc) are the result of a fibrotic process characterized by the excessive and often progressive deposition of collagen and other connective tissue macromolecules in skin and ...
Castro, Susan V.   +2 more
core   +2 more sources

Papillomavirus E5: the smallest oncoprotein with many functions [PDF]

open access: yes, 2011
Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the ...
Borzacchiello, G.   +6 more
core   +4 more sources

Essential role for PDGF signaling in ophthalmic trigeminal placode induction [PDF]

open access: yes, 2008
Much of the peripheral nervous system of the head is derived from ectodermal thickenings, called placodes, that delaminate or invaginate to form cranial ganglia and sense organs.
Bronner-Fraser, Marianne   +1 more
core   +1 more source

Platelet-derived growth factor receptor beta: a novel urinary biomarker for recurrence of non-muscle-invasive bladder cancer. [PDF]

open access: yesPLoS ONE, 2014
Non-muscle-invasive bladder cancer (NMIBC) is one of the most common malignant tumors in the urological system with a high risk of recurrence, and effective non-invasive biomarkers for NMIBC relapse are still needed.
Jiayu Feng   +8 more
doaj   +1 more source

Dasatinib causing Intracerebral Bleeding in a Patient with Chronic Myeloid Leukaemia [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2022
Dasatinib is a potent inhibitor of BCR-ABL (break point cluster-Abelson) kinase, Src family of kinases, C-kit, and Platelet Derived Growth Factor Receptor beta (PDGFR-beta), and used in the treatment of Chronic Myeloid Leukaemia (CML), Ph-positive acute ...
Santosh Govind Rathod   +4 more
doaj   +1 more source

PDGF‐BB‐Dependent Neurogenesis Buffers Depressive‐Like Behaviors by Inhibition of GABAergic Projection from Medial Septum to Dentate Gyrus

open access: yesAdvanced Science, 2023
Hippocampal circuitry stimulation is sufficient to regulate adult hippocampal neurogenesis and ameliorate depressive‐like behavior, but its underlying mechanism remains unclear.
Hou‐Hong Li   +9 more
doaj   +1 more source

Platelets and galectins [PDF]

open access: yes, 2014
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core   +1 more source

Platelet-Derived Growth Factor Receptor β-Subtype Regulates Proliferation and Migration of Gonocytes [PDF]

open access: yesEndocrinology, 2008
Proliferation and migration of gonocytes, the precursors of spermatogonial stem cells, to the germline niche in the basal membrane of the seminiferous tubules, are two crucial events that take place between postnatal d 0.5 (P0.5) and P5.0 in the mouse and involve a selection of the cells that are committed to the germline stem cells lineage.
Basciani S   +8 more
openaire   +4 more sources

Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects

open access: yesAlzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Background Stroke/thromboembolic events, infections, and death are all significantly increased by antipsychotics in dementia but little is known about why they can be harmful. Using a novel application of a drug repurposing paradigm, we aimed to identify
Yasaman Malekizadeh   +8 more
doaj   +1 more source

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