Results 21 to 30 of about 79,696 (126)
Probing the Effects of the FGFR-Inhibitor Derazantinib on Vascular Development in Zebrafish Embryos
Pharmaceuticals, 2020 Angiogenesis is a fundamental developmental process and a hallmark of cancer progression. Receptor tyrosine kinases (RTK) are targets for cancer therapy which may include their action as anti-angiogenic agents.
Maria P. Kotini +4 more
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Dasatinib causing Intracerebral Bleeding in a Patient with Chronic Myeloid Leukaemia [PDF]
Journal of Clinical and Diagnostic Research, 2022 Dasatinib is a potent inhibitor of BCR-ABL (break point cluster-Abelson) kinase, Src family of kinases, C-kit, and Platelet Derived Growth Factor Receptor beta (PDGFR-beta), and used in the treatment of Chronic Myeloid Leukaemia (CML), Ph-positive acute ...
Santosh Govind Rathod +4 more
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PDGFRB (platelet-derived growth factor receptor, beta polypeptide) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on PDGFRB (platelet-derived growth factor receptor, beta polypeptide), with data on DNA, on the protein encoded, and where the gene is implicated.
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Frontiers in Oncology, 2018 Chondrosarcoma is a rare malignancy characterized by the production of cartilage matrix, displaying heterogeneous histopathology and clinical behavior.
Onoufrios Tsavaris +7 more
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Platelet-Derived Growth Factor Receptor β-Subtype Regulates Proliferation and Migration of Gonocytes [PDF]
Endocrinology, 2008 Proliferation and migration of gonocytes, the precursors of spermatogonial stem cells, to the germline niche in the basal membrane of the seminiferous tubules, are two crucial events that take place between postnatal d 0.5 (P0.5) and P5.0 in the mouse and involve a selection of the cells that are committed to the germline stem cells lineage.
Basciani S +8 more
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Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.
Journal of Biological Chemistry, 1992 We have analyzed the nature of ligand-induced shift to higher molecular weight forms of the beta-receptor for platelet-derived growth factor expressed in porcine aortic endothelial cells. The modification of the beta-receptor was found to be due to polyubiquitination, as judged by immunoblotting using an anti-ubiquitin antiserum. A mutant beta-receptor
Carl-Henrik Heldin +2 more
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Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts. [PDF]
The Journal of experimental medicine, 1992 Transforming growth factor beta (TGF-beta), a multifunctional cytokine, is an indirect mitogen for human fibroblasts through platelet-derived growth factor (PDGF), particularly the A ligand-alpha receptor arm of that system. TGF-beta effects on PDGF alpha receptor expression were studied in vitro using ligand binding techniques in three human dermal ...
Edwin A. Smith +4 more
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Stem Cell Research, 2023 PDGFRB encodes platelet-derived growth factor receptor beta (PDGFR-β), a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family.
Seongyea Jo +5 more
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New England Journal of Medicine, 2002 BACKGROUND A small proportion of patients with chronic myeloproliferative diseases have constitutive activation of the gene for platelet-derived growth factor receptor beta (PDGFRB), which encodes a receptor tyrosine kinase.
J. Apperley +18 more
semanticscholar +1 more source
Advanced Science, 2023 Hippocampal circuitry stimulation is sufficient to regulate adult hippocampal neurogenesis and ameliorate depressive‐like behavior, but its underlying mechanism remains unclear.
Hou‐Hong Li +9 more
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