Results 31 to 40 of about 79,696 (126)

Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.

Journal of Biological Chemistry, 2001
Here we provide evidence to show that the platelet-derived growth factor beta receptor is tethered to endogenous G-protein-coupled receptor(s) in human embryonic kidney 293 cells.
Forbes Alderton, S. Rakhit, K. Kong, T. Palmer, B. Sambi, S. Pyne, N. Pyne   +6 more
semanticscholar   +1 more source

Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Background Stroke/thromboembolic events, infections, and death are all significantly increased by antipsychotics in dementia but little is known about why they can be harmful. Using a novel application of a drug repurposing paradigm, we aimed to identify
Yasaman Malekizadeh, Gareth Williams, Mark Kelson, David Whitfield, Jonathan Mill, David A. Collier, Clive Ballard, Aaron R. Jeffries, Byron Creese   +8 more
doaj   +1 more source

Inhibition of glioma cell growth by a truncated platelet-derived growth factor-beta receptor.

Journal of Biological Chemistry, 1994
Abnormal expression of platelet-derived growth factor (PDGF) receptors has been observed in malignant glioma and other tumors such as osteosarcomas and malignant melanomas. However, their role in the development and maintenance of the tumors is not understood. Signaling through the PDGF receptors is activated by ligand-induced dimerization.
Axel Ullrich, E Mann, Laura K. Shawver, L L Germain, Laurie M. Strawn, L M Chu, G Niederfellner, S S Elliger   +7 more
openaire   +3 more sources

Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and non-recognized alpha 2-macroglobulin conformations.

Biochemical Journal, 1993
alpha 2-Macroglobulin (alpha 2M) undergoes a major conformational change when reacting with proteinases or primary amines. This conformational change has been referred to as the 'slow' to 'fast' transformation based on the increase in alpha 2M mobility ...
K. Crookston, D. J. Webb, J. LaMarre, S. Gonias   +3 more
semanticscholar   +1 more source

Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.

American Journal of Pathology, 2009
This study systematically analyzes platelet-derived growth factor (PDGF) receptor expression in six types of common tumors as well as examines associations between PDGF beta-receptor status and clinicopathological characteristics in breast cancer.
Janna Paulsson, T. Sjöblom, P. Micke, F. Pontén, G. Landberg, C. Heldin, J. Bergh, D. Brennan, K. Jirström, A. Ostman   +9 more
semanticscholar   +1 more source

Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing.

American Journal of Pathology, 2006
Connective tissue remodeling provides mammals with a rapid mechanism to repair wounds after injury. Inappropriate activation of this reparative process leads to scarring and fibrosis.
V. Rajkumar, X. Shiwen, Maria Bostrom, P. Leoni, J. Muddle, M. Ivarsson, B. Gerdin, C. Denton, George Bou-Gharios, C. Black, D. Abraham   +10 more
semanticscholar   +1 more source

Stromal Platelet–Derived Growth Factor Receptor-β Signaling Promotes Breast Cancer Metastasis in the Brain

Cancer Research, 2020
This study reveal a previously unknown role for PDGFB-to-PDGFRβ paracrine signaling in the promotion of breast cancer brain metastases and support the prognostic and therapeutic clinical utility of this pathway for patients.
K. Thies, Anisha M. Hammer, B. Hildreth, Sarah A. Steck, Jonathan M. Spehar, R. Kladney, J. Geisler, M. Das, Luke Russell, Jerome F. Bey, Chelsea M Bolyard, R. Pilarski, A. Trimboli, M. Cuitiño, C. Koivisto, D. Stover, L. Schoenfield, Jose Otero, J. Godbout, A. Chakravarti, M. Ringel, B. Ramaswamy, Zaibo Li, B. Kaur, G. Leone, Michael C. Ostrowski, S. Sizemore, Gina M. Sizemore   +27 more
semanticscholar   +1 more source

Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm

Molecular Cytogenetics, 2018
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements ...
Vanessa Fiorini Furtado, Neeraj Y. Saini, William Walsh, Venu Bathini, Patricia M. Miron   +4 more
doaj   +1 more source

The Beneficial Effects of P2X7 Antagonism in Rats with Bile Duct Ligation-induced Cirrhosis. [PDF]

PLoS ONE, 2015
Splanchnic angiogenesis in liver cirrhosis often leads to complications as gastroesophageal variceal hemorrhage and the treatment efficacy is adversely affected by poor portal-systemic collateral vasoresponsiveness related to nitric oxide (NO ...
Hung-Chun Tung, Fa-Yauh Lee, Sun-Sang Wang, Ming-Hung Tsai, Jing-Yi Lee, Teh-Ia Huo, Hui-Chun Huang, Chiao-Lin Chuang, Han-Chieh Lin, Shou-Dong Lee   +9 more
doaj   +1 more source

Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Platelet-derived growth factor (PDGF) isoforms lead to mitogenic, survival, and chemotactic responses in a variety of mesenchymal cell types during development and in the adult.
R. Heuchel, A. Berg, M. Tallquist, K. Åhlén, R. Reed, K. Rubin, L. Claesson-Welsh, C. Heldin, Philippe Soriano   +8 more
semanticscholar   +1 more source