Results 41 to 50 of about 79,696 (126)

Chorioamnionitis Causes Kidney Inflammation, Podocyte Damage, and Pro-fibrotic Changes in Fetal Lambs

open access: yesFrontiers in Pediatrics, 2022
BackgroundPerinatal complications, such as prematurity and intrauterine growth restriction, are associated with increased risk of chronic kidney disease.
Lieke A. Hoogenboom   +11 more
doaj   +1 more source

Effect of Platelet-Derived Growth Factor Receptor-β Inhibition with STI571 on Radioimmunotherapy [PDF]

open access: yesCancer Research, 2005
Abstract Whereas radioimmunotherapy of hematologic malignancies has evolved into a viable treatment option, the responses of solid tumors to radioimmunotherapy are discouraging. The likely cause of this problem is the interstitial hypertension inherent to all solid tumors.
R. Lee Mosley   +9 more
openaire   +2 more sources

Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia.

open access: yesBlood, 2001
Chromosomal translocations involving the platelet-derived growth factor beta receptor (PDGFbetaR) gene have been reported in some patients with chronic myelomonocytic leukemia (CMML).
M. K. Magnússon   +6 more
semanticscholar   +1 more source

Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture

open access: yesCell Communication and Signaling, 2010
Background Uterine leiomyomas (fibroids) are benign smooth muscle tumors that often contain an excessive extracellular matrix (ECM). In the present study, we investigated the interactions between human uterine leiomyoma (UtLM) cells and uterine leiomyoma-
Robboy Stanley J   +9 more
doaj   +1 more source

Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene.

open access: yesBlood, 2002
Platelet-derived growth factor beta receptor (PDGFbetaR) fusion genes have been shown to be critical transforming oncogenes in a subset of patients with chronic myelomonocytic leukemia (CMML).
M. K. Magnússon   +4 more
semanticscholar   +1 more source

Platelet-derived growth factor alpha and beta receptors have overlapping functional activities towards fibroblasts [PDF]

open access: yesFibrogenesis & Tissue Repair, 2013
Platelet-derived growth factor (PDGF) signalling is essential for many key cellular processes in mesenchymal cells. As there is redundancy in signalling between the five PDGF ligand isoforms and three PDGF receptor isoforms, and deletion of either of the receptors in vivo produces an embryonic lethal phenotype, it is not know which ligand and receptor ...
Johanna Donovan   +3 more
openaire   +3 more sources

Mechanism of Hypercholesterolemia-Induced Atherosclerosis

open access: yesReviews in Cardiovascular Medicine, 2022
Hypercholesterolemia is involved in the development of atherosclerosis and is a risk factor for coronary artery disease, stroke, and peripheral vascular disease.
Kailash Prasad, Manish Mishra
doaj   +1 more source

Expression of Platelet-Derived Growth Factor Receptor Beta in Dog Mandible by Beta-Tricalcium Phosphate

open access: yesInternational Journal of Oral-Medical Sciences, 2011
Beta-tricalcium phosphate (β-TCP) has been used for bone regeneration with satisfactory clinical results in accelerating bone formation. However, little is known about the molecular mechanisms enhancing the bone formation by β-TCP. To understand this mechanism, β-TCP was implanted into bone defects of the mandible in beagles and gene expression ...
Yoshimitsu Abiko   +7 more
openaire   +3 more sources

Expressão do P16 e do PDGFR-Beta no adenocarcinoma gástrico

open access: yesRevista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Detectar a expressão imunoistoquímica do p16 e do PDGFR-beta no adenocarcinoma gástrico. MÉTODOS: Foram estudados 36 pacientes submetidos a cirurgia para adenocarcinoma gástrico entre 1998 e 2002 no Hospital da Santa Casa de Porto Alegre.
Rodrigo Pozza Pinto   +3 more
doaj   +1 more source

A proprietary GMP human platelet lysate for the expansion of dermal fibroblasts for clinical applications

open access: yesPlatelets, 2022
Recent years have witnessed the introduction of ex vivo expanded dermal fibroblasts for several cell therapy and tissue-engineering applications, including the treatment of facial scars and burns, representing a promising cell type for regenerative ...
Beatriz Fernández Muñoz   +9 more
doaj   +1 more source

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