Results 41 to 50 of about 144,656 (207)

Chorioamnionitis Causes Kidney Inflammation, Podocyte Damage, and Pro-fibrotic Changes in Fetal Lambs

Frontiers in Pediatrics, 2022
BackgroundPerinatal complications, such as prematurity and intrauterine growth restriction, are associated with increased risk of chronic kidney disease.
Lieke A. Hoogenboom, Lieke A. Hoogenboom, A. Titia Lely, Matthew W. Kemp, Matthew W. Kemp, Matthew W. Kemp, Matthew W. Kemp, Masatoshi Saito, Alan H. Jobe, Tim G. A. M. Wolfs, Tim G. A. M. Wolfs, Michiel F. Schreuder   +11 more
doaj   +1 more source

Radiobrominated benzimidazole-quinoline derivatives as Platelet-derived growth factor receptor beta (PDGFRβ) imaging probes [PDF]

Scientific Reports, 2018
AbstractPlatelet-derived growth factor receptor beta (PDGFRβ) affects in numerous human cancers and has been recognized as a promising molecular target for cancer therapies. The overexpression of PDGFRβ could be a biomarker for cancer diagnosis. Radiolabeled ligands having high affinity for the molecular target could be useful tools for the imaging of ...
Nurmaya Effendi, Kenji Mishiro, Takeshi Takarada, Akira Makino, Daisuke Yamada, Yoji Kitamura, Kazuhiro Shiba, Yasushi Kiyono, Akira Odani, Kazuma Ogawa   +9 more
openaire   +2 more sources

An Inhibitory Effect of Chrysoeriol on Platelet-Derived Growth Factor (PDGF)-Induced Proliferation and PDGF Receptor Signaling in Human Aortic Smooth Muscle Cells

Journal of Pharmacological Sciences, 2009
.: Platelet-derived growth factor (PDGF)-BB is one of the most potent factors in the development and progression of various vascular disorders such as restenosis and atherosclerosis.
Byung-Yoon Cha, Wen Lei Shi, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Je-Tae Woo   +5 more
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Platelet-derived growth factor alpha and beta receptors have overlapping functional activities towards fibroblasts [PDF]

Fibrogenesis & Tissue Repair, 2013
Platelet-derived growth factor (PDGF) signalling is essential for many key cellular processes in mesenchymal cells. As there is redundancy in signalling between the five PDGF ligand isoforms and three PDGF receptor isoforms, and deletion of either of the receptors in vivo produces an embryonic lethal phenotype, it is not know which ligand and receptor ...
Donovan, Johanna, Shiwen, Xu, Norman, Jill, Abraham, David   +3 more
openaire   +2 more sources

Expressão do P16 e do PDGFR-Beta no adenocarcinoma gástrico

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Detectar a expressão imunoistoquímica do p16 e do PDGFR-beta no adenocarcinoma gástrico. MÉTODOS: Foram estudados 36 pacientes submetidos a cirurgia para adenocarcinoma gástrico entre 1998 e 2002 no Hospital da Santa Casa de Porto Alegre.
Rodrigo Pozza Pinto, Fernando Krebs Cirne Lima, Jane M U Kulkzynski, Luis Fernando Moreira   +3 more
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Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Myc Is an Essential Negative Regulator of Platelet-Derived Growth Factor Beta Receptor Expression [PDF]

Molecular and Cellular Biology, 2000
Platelet-derived growth factor BB (PDGF BB) is a potent mitogen for fibroblasts as well as many other cell types. Interaction of PDGF BB with the PDGF beta receptor (PDGF-betaR) activates numerous signaling pathways and leads to a decrease in receptor expression on the cell surface.
S K, Oster, W W, Marhin, C, Asker, L M, Facchini, P A, Dion, K, Funa, M, Post, J M, Sedivy, L Z, Penn   +8 more
openaire   +2 more sources

Biophysical regulation of stem cell behavior within the niche. [PDF]

, 2012
Stem cells reside within most tissues throughout the lifetimes of mammalian organisms. To maintain their capacities for division and differentiation and thereby build, maintain, and regenerate organ structure and function, these cells require extensive ...
Conway, Anthony, Schaffer, David V
core   +1 more source

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]

, 2018
Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A., Kaplan, Mark H., Ocana, Jesus A., Pawelzik, Sven-Christian, Romer, Eric, Sahu, Ravi, Travers, Jeffrey B.   +6 more
core   +1 more source

The Interaction Between Spinal PDGFRβ and μ Opioid Receptor in the Activation of Microglia in Morphine-Tolerant Rats

Journal of Pain Research, 2020
Zheng Li, Xiaoqian Jia, Xiaoling Peng, Feng Gao Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Feng GaoDepartment of ...
Li Z, Jia X, Peng X, Gao F
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