Results 51 to 60 of about 79,696 (126)

Platelet-derived growth factor (PDGF)-AB-mediated phosphorylation of PDGF β receptors [PDF]

Biochemical Journal, 1994
Platelet-derived growth factor (PDGF) stimulates the proliferation of Balb/c-3T3 fibroblasts through binding and subsequent activation of PDGF receptors. Activation of the PDGF receptors has been proposed to involve receptor dimerization. PDGF-AB has been shown to bind PDGF alpha and beta receptor subunits to form PDGF alpha beta and alpha alpha ...
H D Love, W. J. Pledger, S R Coats
openaire   +3 more sources

A dual inhibitor of platelet-derived growth factor beta-receptor and Src kinase activity potently interferes with motogenic and mitogenic responses to PDGF in vascular smooth muscle cells. A novel candidate for prevention of vascular remodeling.

Circulation Research, 1999
PP1 has previously been described as an inhibitor of the Src-family kinases p56(Lck) and FynT. We have therefore decided to use PP1 to determine the functional role of Src in platelet-derived growth factor (PDGF)-induced proliferation and migration of ...
J. Waltenberger, A. Uecker, Jens Kroll, Hedwig Frank, U. Mayr, J. Bjorge, D. Fujita, A. Gazit, Vinzenz Hombach, A. Levitzki, F. Böhmer   +10 more
semanticscholar   +1 more source

Radiobrominated benzimidazole-quinoline derivatives as Platelet-derived growth factor receptor beta (PDGFRβ) imaging probes [PDF]

Scientific Reports, 2018
AbstractPlatelet-derived growth factor receptor beta (PDGFRβ) affects in numerous human cancers and has been recognized as a promising molecular target for cancer therapies. The overexpression of PDGFRβ could be a biomarker for cancer diagnosis. Radiolabeled ligands having high affinity for the molecular target could be useful tools for the imaging of ...
Nurmaya Effendi, Kenji Mishiro, Takeshi Takarada, Akira Makino, Daisuke Yamada, Yoji Kitamura, Kazuhiro Shiba, Yasushi Kiyono, Akira Odani, Kazuma Ogawa   +9 more
openaire   +3 more sources

The Interaction Between Spinal PDGFRβ and μ Opioid Receptor in the Activation of Microglia in Morphine-Tolerant Rats

Journal of Pain Research, 2020
Zheng Li, Xiaoqian Jia, Xiaoling Peng, Feng Gao Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Feng GaoDepartment of ...
Li Z, Jia X, Peng X, Gao F
doaj  

Targeting VEGF-VEGFR Pathway by Sunitinib in Peripheral Primitive Neuroectodermal Tumor, Paraganglioma and Epithelioid Hemangioendothelioma: Three Case Reports

Case Reports in Oncology, 2013
Sunitinib malate (Sutent™; Pfizer Inc., New York, N.Y., USA) is a small molecule kinase inhibitor with activity against a number of tyrosine kinase receptors, including vascular endothelial growth factor receptors, stem-cell factor receptor, and platelet-
Tiziana Prochilo, Giordano Savelli, Paola Bertocchi, Chiara Abeni, Luigina Rota, Anna Rizzi, Alberto Zaniboni   +6 more
doaj   +1 more source

Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. [PDF]

PLoS Biology, 2003
The platelet-derived growth factor beta receptor (PDGFRbeta) is known to activate many molecules involved in signal transduction and has been a paradigm for receptor tyrosine kinase signaling for many years.
Michelle D Tallquist, Wendy J French, Philippe Soriano   +2 more
doaj   +1 more source

The causal associations between growth factors and constipation: a two-sample Mendelian randomization study

Frontiers in Physiology, 2023
Introduction: Certain growth factors (GFs) are associated with constipation, but few studies has analyzed the causal associations between the two. Therefore, this study used two-sample Mendelian randomization (MR) to systematically analyze the causal ...
Jiachen Wang, Mingyi Yang, Ke Xu, Xianjie Wan, Jiale Xie, Hui Yu, Jiaxin Fang, Zehua Wang, Peng Xu   +8 more
doaj   +1 more source

The Epidermal Growth Factor Receptor Associates with and Recruits Phosphatidylinositol 3-Kinase to the Platelet-derived Growth Factor β Receptor [PDF]

Journal of Biological Chemistry, 1998
Receptor tyrosine kinases are classified into subfamilies, which are believed to function independently, with heterodimerization occurring only within the same subfamily. In this study, we present evidence suggesting a direct interaction between the epidermal growth factor (EGF) receptor (EGFR) and the platelet-derived growth factor beta (PDGFbeta ...
Jane Ren, Thorbergur Högnason, Kari Stefansson, Amyn A. Habib, Rajiv R. Ratan   +4 more
openaire   +3 more sources

Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: an in vitro study

Stem Cell Research & Therapy, 2021
Background Autologous adipose tissue transfer may be performed for aesthetic needs following the resection of dermatofibrosarcoma protuberans (DFSP), the most common cutaneous soft tissue sarcoma, excluding Kaposi sarcoma.
Zhaoqi Yuan, Zhu Zhu, Fangxing Zhu, Feixue Ding, Yinmin Wang, Xiuxia Wang, Xusong Luo, Jun Yang, Fei Liu, Di Sun   +9 more
doaj   +1 more source

The Role of Alpha and Beta Platelet-Derived Growth Factor Receptor in the Vascular Response to Injury in Nonhuman Primates [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 1999
Abstract —Restenosis remains a significant clinical problem associated with mechanical interventional procedures for arterial revascularization or repair, including coronary angioplasty and stenting. Studies with rodents have established that platelet-derived growth factor (PDGF), a potent chemotactic and mitogenic agent for ...
Andrew B. Kelly, Andrea Hancock, Changyi Chen, Monique M. H. Marijianowski, Vanitha Ramakrishnan, Josiah N. Wilcox, Oscar McCook, Neill A. Giese, Larry J. Fretto, Stephen R. Hanson, James A. Koziol   +10 more
openaire   +3 more sources