Results 61 to 70 of about 79,696 (126)

Arsenite suppresses angiogenesis of vascular endothelial cells mediated by Platelet Derived Growth Factor Receptor-beta [PDF]

Environmental Toxicology and Pharmacology, 2016
The present study aimed to investigate the effects of sodium arsenite (NaAsO2) on the angiogenesis of human umbilical vein endothelial cells (HUVECs) and the mechanism involved. Firstly, a Matrigel-based in vitro angiogenesis assay demonstrated that arsenite suppressed the angiogenesis of HUVECs in a dose-dependent manner.
Ronggui Li, Yang Wang, Xin Sun, Xiaotong Wang, Xuejin Su, Zhen Yue, Yan Mou, Haiying Zhang   +7 more
openaire   +3 more sources

Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor beta receptor.

Proceedings of the National Academy of Sciences of the United States of America, 1998
The bovine papillomavirus E5 protein is a 44-aa transmembrane protein that forms a stable complex with the cellular platelet-derived growth factor (PDGF) beta receptor and induces constitutive tyrosine phosphorylation and activation of the receptor ...
C. C. Lai, C. Henningson, D. DiMaio
semanticscholar   +1 more source

PDGFRB Promotes Liver Metastasis Formation of Mesenchymal-Like Colorectal Tumor Cells

Neoplasia: An International Journal for Oncology Research, 2013
In epithelial tumors, the platelet-derived growth factor receptor B (PDGFRB) is mainly expressed by stromal cells of mesenchymal origin. Tumor cells may also acquire PDGFRB expression following epithelial-to-mesenchymal transition (EMT), which occurs ...
Ernst J.A. Steller, Danielle A. Raats, Jan Koster, Bert Rutten, Klaas M. Govaert, Benjamin L. Emmink, Nikol Snoeren, Sander R. van Hooff, Frank C.P. Holstege, Coen Maas, Rinkes Inne H.M. Borel, Onno Kranenburg   +11 more
doaj   +1 more source

Platelet-Rich Gel Supernatants Stimulate the Release of Anti-Inflammatory Proteins on Culture Media of Normal Equine Synovial Membrane Explants

Veterinary Medicine International, 2015
The aims were as follows: (1) to evaluate the effects at 48 and 96 h of two concentrations (25 and 50%) of leukocyte and platelet-rich gel (L-PRG) and pure PRG (P-PRG) supernatants on the production/degradation in normal equine synovial membrane explants
Diana L. Ríos, Catalina López, Jorge U. Carmona   +2 more
doaj   +1 more source

Interaction between 4-hydroxy-2,3-alkenals and the platelet-derived growth factor-beta receptor. Reduced tyrosine phosphorylation and downstream signaling in hepatic stellate cells.

Journal of Biological Chemistry, 2000
Hepatic stellate cells (HSC) undergo activation toward myofibroblast-like cells during early stages of liver injury associated with fibrogenesis. Platelet-derived growth factor (PDGF), particularly its BB isoform, has been identified as the most potent ...
G. Robino, M. Parola, F. Marra, A. Caligiuri, R. D. Franco, E. Zamara, G. Bellomo, P. Gentilini, M. Pinzani, M. U. Dianzani   +9 more
semanticscholar   +1 more source

Expression profiling and Ingenuity biological function analyses of interleukin-6- versus nerve growth factor-stimulated PC12 cells

BMC Genomics, 2009
Background The major goal of the study was to compare the genetic programs utilized by the neuropoietic cytokine Interleukin-6 (IL-6) and the neurotrophin (NT) Nerve Growth Factor (NGF) for neuronal differentiation. Results The designer cytokine Hyper-IL-
Dimitriades-Schmutz Beatrice, März-Weiss Pia, Certa Ulrich, Bedoucha Marc, Walker Gaby, Kunz Dieter, Otten Uwe   +6 more
doaj   +1 more source

Mini-Review on Targeted Treatment of Desmoplastic Small Round Cell Tumor

Frontiers in Oncology, 2020
Desmoplastic small round cell tumor (DSRCT) is a devastating disease which most commonly affects adolescents, with a male predominance. Despite the best multimodality treatment efforts, most patients will ultimately not survive more than 3–5 years after ...
Tomas S. Bexelius, Tomas S. Bexelius, Ajla Wasti, Ajla Wasti, Julia C. Chisholm, Julia C. Chisholm   +5 more
doaj   +1 more source

Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. [PDF]

PLoS Genetics, 2013
Coronary heart disease (CHD) is the leading cause of mortality in both developed and developing countries worldwide. Genome-wide association studies (GWAS) have now identified 46 independent susceptibility loci for CHD, however, the biological and ...
Clint L Miller, D Ryan Anderson, Ramendra K Kundu, Azad Raiesdana, Sylvia T Nürnberg, Roxanne Diaz, Karen Cheng, Nicholas J Leeper, Chung-Hsing Chen, I-Shou Chang, Eric E Schadt, Chao Agnes Hsiung, Themistocles L Assimes, Thomas Quertermous   +13 more
doaj   +1 more source

Glucose-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-beta receptor potentiates vascular smooth muscle cell chemotaxis.

Diabetes, 2003
The aim of this study was to investigate the effects of elevated D-glucose concentrations on vascular smooth muscle cell (VSMC) expression of the platelet-derived growth factor (PDGF)beta receptor and VSMC migratory behavior.
M. Campbell, W. Allen, J. Silversides, E. Trimble   +3 more
semanticscholar   +1 more source

Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-β

Journal of Biological Chemistry, 1989
The binding of three radiolabeled isoforms of platelet-derived growth factor (PDGF), 125I-PDGF-AA, 125I-PDGF-AB, and 125I-PDGF-BB, is differentially affected by exposure of quiescent 3T3 cells to transforming growth factor-beta (TGF-beta). By 24 h after exposure to TGF-beta, binding of 125I-PDGF-AA and 125I-PDGF-AB is almost completely lost, whereas ...
Ronald A. Seifert, Daniel F. Bowen-Pope, R G K Gronwald   +2 more
openaire   +3 more sources