Results 71 to 80 of about 79,696 (126)

Multiple allostery in the regulation of PDGFR beta kinase activities

Acta Biochimica et Biophysica Sinica
Platelet-derived growth factor receptor beta (PDGFRβ), a type III receptor tyrosine kinase (RTK) with a featured kinase insert, regulates important cellular functions. Dysregulation of PDGFRβ is associated with cardiovascular and fibrosis diseases. Thus,
Zhang Yanfeng, Wang Meimei, Shao Guangcan, Shang Qingbin, Dong Mengqiu, Qin Xiaohong, Mi Li-Zhi   +6 more
doaj   +1 more source

Stromal PDGFR-beta expression is a prognostic factor in high-grade serous ovarian cancer patients but is it also predictive for response to antiangiogenic treatment?

Journal of Cancer Research and Clinical Oncology
Objective In advanced ovarian cancer, the majority of patients receive anti-angiogenic treatment with bevacizumab. However, its use is often associated with severe side effects, and not all patients benefit from the therapy.
Annabelle Volk, Charlotte von Bülow, Aysche Stern, Ronald Simon, Eike Burandt, Guido Sauter, Barbara Schmalfeldt, Leticia Oliveira-Ferrer   +7 more
doaj   +1 more source

Multiple oligomerization domains of KANK1-PDGFRβ are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK

Haematologica, 2011
Background KANK1-PDGFRB is a fusion gene generated by the t(5;9) translocation between KANK1 and the platelet-derived growth factor receptor beta gene PDGFRB.
Sandrine Medves, Laura A. Noël, Carmen P. Montano-Almendras, Roxana I. Albu, Hélène Schoemans, Stefan N. Constantinescu, Jean-Baptiste Demoulin   +6 more
doaj   +1 more source

Expression of platelet-derived growth factor beta receptor on human monocyte-derived macrophages and effects of platelet-derived growth factor BB dimer on the cellular function.

Journal of Biological Chemistry, 1993
Platelet-derived growth factor (PDGF) plays an important role in the process of atherosclerosis which is characterized by the presence of macrophage-derived foam cells. In the present study, the induction of the mRNA of PDGF-beta receptor was demonstrated during cell differentiation of human monocyte-macrophages, whereas no mRNA was detected in the ...
Toshiya Inaba, Hitoshi Shimano, K Harada, Nobuhiro Yamada, Masako Shimada, Takanari Gotoda, Masako Kawamura, Y Watanabe, Yoshio Yazaki, Jun-ichi Ohsuga   +9 more
openaire   +3 more sources

The platelet-derived growth factor beta-receptor kinase insert confers specific signaling properties to a chimeric fibroblast growth factor receptor.

Journal of Biological Chemistry, 1992
Signal transduction by tyrosine kinase growth factor receptors involves ligand-induced phosphorylation of substrates for the kinase, resulting in mediation of common or receptor-specific biological signals. We have compared signal transduction pathways for the fibroblast growth factor receptor-1 (FGFR-1), the platelet-derived growth factor beta ...
E Landgren, Stefan Wennström, Lena Claesson-Welsh, Peter Blume-Jensen   +3 more
openaire   +3 more sources

Sorafenib for the treatment of unresectable hepatocellular carcinoma

Biologics: Targets & Therapy, 2008
Junji FuruseDepartment of Internal Medicine, Medical Oncology, School of Medicine, Kyorin UniversityAbstract: Raf kinases and vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases are ...
Junji Furuse
doaj  

Dynamin inhibitors impair platelet-derived growth factor β-receptor dimerization and signaling

Experimental Cell Research, 2019
The role of plasma membrane composition and dynamics in the activation process of receptor tyrosine kinases (RTKs) is still poorly understood. In this study we have investigated how signaling via the RTK, platelet-derived growth factor β-receptor (PDGFR-β) is affected by Dynasore or Dyngo-4a, which are commonly used dynamin inhibitors.
Heldin, Johan, Rubin Sander, Marie, Leino, Mattias, Thomsson, Sara, Lennartsson, Johan, Söderberg, Ola   +5 more
openaire   +5 more sources

MicroRNA-26b-5p Inhibits Mouse Liver Fibrogenesis and Angiogenesis by Targeting PDGF Receptor-Beta

Molecular Therapy: Nucleic Acids, 2019
Here microRNAs (miRNAs) with potentially therapeutic effects were screened and explored during liver fibrogenesis and angiogenesis via targeting the important mediators.
Le Yang, Chengbin Dong, Jingjing Yang, Lin Yang, Na Chang, Changbo Qi, Liying Li   +6 more
doaj  

An Inhibitory Effect of Chrysoeriol on Platelet-Derived Growth Factor (PDGF)-Induced Proliferation and PDGF Receptor Signaling in Human Aortic Smooth Muscle Cells

Journal of Pharmacological Sciences, 2009
.: Platelet-derived growth factor (PDGF)-BB is one of the most potent factors in the development and progression of various vascular disorders such as restenosis and atherosclerosis.
Byung-Yoon Cha, Wen Lei Shi, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Je-Tae Woo   +5 more
doaj  

Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (PDGF) receptor activation by PDGF-AB.

Journal of Biological Chemistry, 1991
We investigated the ability of highly purified recombinant platelet-derived growth factor (PDGF) AB to interact with the products of alpha and beta receptor genes expressed in cells independently or concurrently. Although PDGF-AB lacked any detectable ability to bind or activate beta receptors in cells expressing only this receptor, efficient beta ...
Stuart A. Aaronson, D. Lombardi, Artrip J, Jin-Chen Yu, M. A. Heidaran, A. Thomason, Timothy P. Fleming, Jacalyn H. Pierce   +7 more
openaire   +3 more sources