Role of noncoding RNA in vascular remodelling [PDF]
, 2016 Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H. +2 more
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Mildly Oxidized LDL Induces Activation of Platelet-Derived Growth Factor β-Receptor Pathway [PDF]
Circulation, 2001 Background Mildly oxidized LDL (moxLDL) is thought to play a role in atherogenesis. MoxLDL induces derivatization of cell proteins and triggers a variety of intracellular signaling.
I, Escargueil-Blanc +7 more
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BMC Genomics, 2009 Background The major goal of the study was to compare the genetic programs utilized by the neuropoietic cytokine Interleukin-6 (IL-6) and the neurotrophin (NT) Nerve Growth Factor (NGF) for neuronal differentiation. Results The designer cytokine Hyper-IL-
Dimitriades-Schmutz Beatrice +6 more
doaj +1 more source
Stem Cell Research & Therapy, 2021 Background Autologous adipose tissue transfer may be performed for aesthetic needs following the resection of dermatofibrosarcoma protuberans (DFSP), the most common cutaneous soft tissue sarcoma, excluding Kaposi sarcoma.
Zhaoqi Yuan +9 more
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Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoid. [PDF]
, 2008 Equine sarcoids are benign fibroblastic skin tumours that are recognized throughout the world. Infection with bovine papillomavirus (BPV) types 1 and 2 has been implicated as a major factor in disease development; however, the cellular mechanisms ...
BORZACCHIELLO, GIUSEPPE +4 more
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Ligand Stimulation Reduces Platelet-derived Growth Factor β-Receptor Susceptibility to Tyrosine Dephosphorylation [PDF]
Journal of Biological Chemistry, 2001 Ligand binding to the platelet-derived growth factor (PDGF) beta-receptor leads to increased receptor tyrosine phosphorylation as a consequence of dimerization-induced activation of the intrinsic receptor tyrosine kinase activity. In this study we asked whether ligand-stimulated PDGF beta-receptor tyrosine phosphorylation, to some extent, also involved
A, Shimizu +3 more
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Multiple allostery in the regulation of PDGFR beta kinase activities
Acta Biochimica et Biophysica SinicaPlatelet-derived growth factor receptor beta (PDGFRβ), a type III receptor tyrosine kinase (RTK) with a featured kinase insert, regulates important cellular functions. Dysregulation of PDGFRβ is associated with cardiovascular and fibrosis diseases. Thus,
Zhang Yanfeng +6 more
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Tumor angiogenic switch determines sustained proliferative malignant transformation in tumorigenesis and overlaps with para-inflammatory phenomena [PDF]
, 2015 Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
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Receptor tyrosine kinase expression and phosphorylation in canine nasal carcinoma [PDF]
Master of Science in Biomedical SciencesDepartment of Clinical SciencesMary Lynn HigginbothamThis study evaluated sixteen canine nasal carcinoma and five normal nasal epithelium samples for expression and phosphorylation of known targets of toceranib ...
Hocker, Samuel
core
A lesson for cancer research : placental microarray gene analysis in preeclampsia [PDF]
, 2012 Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated.
Louwen, Frank +4 more
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