Results 61 to 70 of about 23,240 (230)

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Serotonin 5-HT1A Receptors Regulate NMDA Receptor Channels through a Microtubule-Dependent Mechanism [PDF]

Journal of Neuroscience, 2005
The serotonin system and NMDA receptors (NMDARs) in prefrontal cortex (PFC) are both critically involved in the regulation of cognition and emotion under normal and pathological conditions; however, the interactions between them are essentially unknown.
Eunice Y, Yuen, Qian, Jiang, Paul, Chen, Zhenglin, Gu, Jian, Feng, Zhen, Yan   +5 more
openaire   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Ingestão de alimento após a ativação de receptores 5-HT1A do núcleo arqueado do hipotálamo e da área hipotalâmica lateral de ratas em duas fases do ciclo estral [PDF]

, 2009
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2009.O presente estudo examinou os efeitos da injeção local de metergolina (MET, antagonista de ...
Steffens, Sérgio Murilo
core  

The role of GABAB(1) receptor isoforms in anxiety and depression : genetic and pharmacological studies in the mouse [PDF]

, 2007
Anxiety and depression disorders represent common, serious and growing health problems world-wide. The neurobiological basis of anxiety and depression, however, remains poorly understood.
Jacobson, Laura Helen
core   +1 more source

Comparison of High and Low Affinity Serotonin 1A Receptors by PET In Vivo in Nonhuman Primates

Journal of Pharmacological Sciences, 2012
Serotonin (5-HT) 1A receptors exist in high and low affinity states. Agonist ligands bind preferentially to the high affinity state receptors, providing a more functionally relevant measure than antagonist binding.
J.S. Dileep Kumar, Matthew S. Milak, Vattoly J. Majo, Jaya Prabhakaran, Pratap Mali, Lyudmila Savenkova, J. John Mann, Ramin V. Parsey   +7 more
doaj   +1 more source

Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice

Frontiers in Pharmacology, 2020
Growing evidence suggests an important role of fluoxetine with serotonin 5-HT1A and 5-HT2C receptors in the modulation of emotion and nociception in brain areas such as the amygdala and periaqueductal gray (PAG).
Daniela Baptista-de-Souza, Daniela Baptista-de-Souza, Daniela Baptista-de-Souza, Lígia Renata Rodrigues Tavares, Lígia Renata Rodrigues Tavares, Elke Mayumi Furuya-da-Cunha, Elke Mayumi Furuya-da-Cunha, Paulo Eduardo Carneiro de Oliveira, Paulo Eduardo Carneiro de Oliveira, Lucas Canto-de-Souza, Lucas Canto-de-Souza, Ricardo Luiz Nunes-de-Souza, Ricardo Luiz Nunes-de-Souza, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza, Azair Canto-de-Souza, Azair Canto-de-Souza, Azair Canto-de-Souza   +17 more
doaj   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

In Vitro and In Vivo Characterization of PCC0104005, a Novel Modulator of Serotonin-Dopamine Activity, as an Atypical Antipsychotic Drug

Scientific Reports, 2018
PCC0104005 is a novel drug candidate for treating schizophrenia that displays high affinity for serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-
Yanan Xu, Xiaoyin Zhu, Hongbo Wang, Shanyue Sun, Xin Yue, Jingwei Tian   +5 more
doaj   +1 more source

The OPRM1 gene and interactions with the 5-HT1a gene regulate conditioned pain modulation in fibromyalgia patients and healthy controls.

PLoS ONE, 2022
Fibromyalgia (FM) patients have dysfunctional endogenous pain modulation, where opioid and serotonergic signaling is implicated. The aim of this study was to investigate whether genetic variants in the genes coding for major structures in the opioid and ...
Jeanette Tour, Angelica Sandström, Diana Kadetoff, Martin Schalling, Eva Kosek   +4 more
doaj   +1 more source