Psychedelics promote plasticity by directly binding to BDNF receptor TrkB [PDF]
Nature Neuroscience, 2023 Abstract Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants. We recently reported that pharmacologically diverse antidepressants, including fluoxetine and ketamine, act by binding to TrkB, the receptor for BDNF ...
Mykhailo Girych +2 more
exaly +10 more sources
Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
Cells, 2022 Serotonin receptor 5-HT2A and tropomyosin receptor kinase B (TrkB) strongly contribute to neuroplasticity regulation and are implicated in numerous neuronal disorders.
Tatiana Ilchibaeva +7 more
doaj +3 more sources
Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation. [PDF]
PLoS ONE, 2013 Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) are two neurotrophins that play distinct roles in geniculate (taste) neuron survival, target innervation, and taste bud formation.
Da Fei, Robin F Krimm
doaj +4 more sources
Interaction between a Novel Oligopeptide Fragment of the Human Neurotrophin Receptor TrkB Ectodomain D5 and the C-Terminal Fragment of Tetanus Neurotoxin [PDF]
Molecules, 2021 This article presents experimental evidence and computed molecular models of a potential interaction between receptor domain D5 of TrkB with the carboxyl-terminal domain of tetanus neurotoxin (Hc-TeNT).
Ana Candalija +5 more
doaj +2 more sources
Neuron and astrocyte specific 5mC and 5hmC signatures of BDNF’s receptor, TrkB [PDF]
Frontiers in Molecular NeuroscienceBrain derived neurotrophic factor (BDNF) is the most studied trophic factor in the central nervous system (CNS), and its role in the maturation of neurons, including synapse development and maintenance has been investigated intensely for over three ...
Xiaoran Wei +4 more
doaj +2 more sources
Transactivation of TrkB Receptors by Oxytocin and Its G Protein-Coupled Receptor
Frontiers in Molecular Neuroscience, 2022 Brain-derived Neurotrophic Factor (BDNF) binds to the TrkB tyrosine kinase receptor, which dictates the sensitivity of neurons to BDNF. A unique feature of TrkB is the ability to be activated by small molecules in a process called transactivation.
Mariela Mitre +18 more
doaj +3 more sources
Regulation of NTRK2 alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity [PDF]
Cell Death and DiseaseBDNF signaling through its receptor TRKB plays a critical role in brain development, neuroplasticity, and homeostasis. Alternative splicing of the TRKB gene, NTRK2, generates either the full-length receptor (TRKB-FL) or a truncated isoform (TRKB-T1) that
María Duarte-Ruiz +12 more
doaj +2 more sources
Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases [PDF]
Breast Cancer Research, 2017 Background Patients with primary breast cancer that is positive for human epidermal growth factor receptor 2 (Her2+) have a high risk of developing metastases in the brain.
Cecilia Choy +7 more
doaj +2 more sources
Retrograde transport of neurotrophin receptor TrkB-FL induced by excitotoxicity regulates Golgi stability and is a target for stroke neuroprotection [PDF]
Cell Death and DiseaseExcitotoxicity, aberrant function of survival pathways dependent on brain-derived neurotrophic factor (BDNF), and disruption of the Golgi complex are shared pathological hallmarks in relevant neurological diseases, including stroke.
Gema María Esteban-Ortega +2 more
doaj +2 more sources
Long-term functional rescue of trauma-induced vision loss by a novel, small molecule TrkB modulator. [PDF]
PLoS ONEBrain-derived neurotrophic factor (BDNF) signaling through the tropomyosin-related kinase B (TrkB) receptor promotes neuronal growth and survival following an injury.
Shweta Modgil +5 more
doaj +2 more sources