Results 101 to 110 of about 40,205 (225)

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

The novel TrkB receptor agonist 7,8‐dihydroxyflavone enhances neuromuscular transmission [PDF]

Muscle & Nerve, 2012
AbstractNeurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin‐related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8‐dihydroxyflavone (7,8‐DHF), selectively activates TrkB receptors.
Carlos B, Mantilla, Leonid G, Ermilov
openaire   +2 more sources

Features of Neural Network Formation and Their Functions in Primary Hippocampal Cultures in the Context of Chronic TrkB Receptor System Influence

Frontiers in Physiology, 2019
Discovering the mechanisms underlying homeostatic regulation in brain neural network formation and stability processes is one of the most urgent tasks in modern neuroscience.
Tatiana A. Mishchenko, Tatiana A. Mishchenko, Elena V. Mitroshina, Elena V. Mitroshina, Alexandra V. Usenko, Natalia V. Voronova, Tatiana A. Astrakhanova, Olesya M. Shirokova, Innokentiy A. Kastalskiy, Maria V. Vedunova   +9 more
doaj   +1 more source

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor [PDF]

Journal of Cell Science, 2004
The Trk family of receptor tyrosine kinases and the p75 receptor (p75NTR) mediate the effects of neurotrophins on neuronal survival, differentiation and synaptic plasticity. The neurotrophin BDNF and its cognate receptor tyrosine kinase, TrkB.FL, are highly expressed in neurons of the central nervous system. At later stages in postnatal development the
Matthias, Hartmann, Tanja, Brigadski, Kai S, Erdmann, Bettina, Holtmann, Michael, Sendtner, Frank, Narz, Volkmar, Lessmann   +6 more
openaire   +2 more sources

Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2 [PDF]

, 2006
FGF-2, a potent multifunctional and neurotrophic growth factor, is widely expressed in the brain and upregulated in cerebral ischemia. Previous studies have shown that intraventricularly or systemically administered FGF-2 reduces the size of cerebral ...
Bohlen und Halbach, Oliver von, Dono, Rosanna, Kiprianova, Irina, Krause, Sonja, Schindowski, Katharina, Schwaninger, Markus, Unsicker, Klaus   +6 more
core  

an immunohistochemical study [PDF]

, 2016
Background The roles of the neurotrophins NGF (Neurotrophic growth factor) and BDNF (brain-derived neurotrophic factor) in neuronal growth and development are already known. Meanwhile, the neurotrophin receptors TrkA (tropomyosin related kinase A), TrkB,
Dewanto, Agung, Dudas, Jozsef, Glueckert, Rudolf, Mechsner, Sylvia, Schrott-Fischer, Anneliese, Seeber, Beata, Wildt, Ludwig   +6 more
core   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Ablation of TrkB from Enkephalinergic Precursor-Derived Cerebellar Granule Cells Generates Ataxia

Biology
In ataxia disorders, motor incoordination (ataxia) is primarily linked to the dysfunction and degeneration of cerebellar Purkinje cells (PCs). In spinocerebellar ataxia 6 (SCA6), for example, decreased BDNF–TrkB signalling appears to contribute to PC ...
Elena Eliseeva, Mohd Yaseen Malik, Liliana Minichiello   +2 more
doaj   +1 more source