Results 111 to 120 of about 40,205 (225)

Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library [PDF]

, 2018
The diverse physiological roles of the neurotrophin family have long prompted exploration of their potential as therapeutic agents for nerve injury and neurodegenerative diseases.
Allen, Nicholas D., Barde, Yves-Alain, Binley, Kate E., Chacon-Fernandez, Pedro, DiStefano, Peter S., Grande, Geramie, Lerner, Richard A., Li, Meng, Lin, Chih-Wei, Lindsay, Ronald M., Merkouris, Spyros, Nan, Xinsheng, Stepanov, Alexey V., Wu, Nicholas C., Xie, Jia   +14 more
core   +2 more sources

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Peptide-mediated targeting of liposomes to TrkB receptor-expressing cells

International Journal of Nanomedicine, 2012
The neurotrophic receptor tyrosine kinase B (TrkB) has diverse signaling roles in neurons and tumor cells. Accordingly, its suppressive targeting is of interest in neuroblastoma and other tumors, whereas its role in improving survival is focused in neurons.
Kinnunen, Paavo, Ranjan,, Sood,, Dudas,, Glueckert,, Roy,, Schrott-Fischer,, Pyykko,Ilmari   +7 more
openaire   +5 more sources

Development of Pleiotropic TrkB and 5-HT₄ Receptor Ligands as Neuroprotective Agents

Molecules
One common event that is the most detrimental in neurodegenerative disorders, even though they have a complex pathogenesis, is the increased rate of neuronal death.
Mirjana Antonijevic, Despoina Charou, Audrey Davis, Thomas Curel, Maria Valcarcel, Isbaal Ramos, Patricia Villacé, Sylvie Claeysen, Patrick Dallemagne, Achille Gravanis, Ioannis Charalampopoulos, Christophe Rochais   +11 more
doaj   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]

, 2001
Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P, Lotto, RB, Price, DJ, Vali, L   +3 more
core   +1 more source

A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring

Obesity Reviews, EarlyView.
ABSTRACT Obesity is one of the most prevalent health problems worldwide, and global obesity rates continue to rise. Consequently, rates of obesity in expecting mothers and fathers have also increased. The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early‐life exposure to adverse environmental conditions contributes to
Hannah Chadwick, Victorio Bambini Junior, Neil Dawson, Cheryl A. Hawkes   +3 more
wiley   +1 more source

TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells

BMC Cancer, 2010
Background Aberrant regulation in the invasion of cancer cells is closely associated with their metastatic potentials. TrkB functions as a receptor tyrosine kinase and is considered to facilitate tumor metastasis.
Lu Yao, Li Chunyan, Zhang Ying, Zhang Qingfu, Luo Wenting, Guo Dawei, Zhang Siyang, Cui Zeshi, Qiu Xueshan   +8 more
doaj   +1 more source

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. [PDF]

, 2013
The p75 neurotrophin receptor (p75(NTR)) is a member of the tumor necrosis factor receptor superfamily with a widespread pattern of expression in tissues such as the brain, liver, lung, and muscle.
Akassoglou, Katerina, Baeza-Raja, Bernat, Eckel-Mahan, Kristin, Ptácek, Louis J, Sassone-Corsi, Paolo, Tsigelny, Igor F, Vagena, Eirini, Zhang, Luoying   +7 more
core   +2 more sources