Results 11 to 20 of about 40,205 (225)

BDNF/TrkB pathway activation in D1 receptor-expressing striatal projection neurons plays a protective role against L-DOPA-induced dyskinesia

Neurobiology of Disease, 2023
L-DOPA-induced dyskinesia (LID) is a frequent adverse side effect of L-DOPA treatment in Parkinson's disease (PD). Understanding the mechanisms underlying the development of these motor disorders is needed to reduce or prevent them.
Assunta Pelosi, Yukari Nakamura, Jean-Antoine Girault, Denis Hervé   +3 more
doaj   +1 more source

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance New effective therapies are desperately needed for lung cancer because most current lung cancer treatments rarely prevent the metastatic disease that causes the majority of patient deaths. We discovered that the neurotrophin receptor TrkB is an important therapeutic target in metastatic lung cancer using a combination of cell ...
Kerstin W, Sinkevicius, Christina, Kriegel, Kelly J, Bellaria, Jaewon, Lee, Allison N, Lau, Kristen T, Leeman, Pengcheng, Zhou, Alexander M, Beede, Christine M, Fillmore, Deborah, Caswell, Juliana, Barrios, Kwok-Kin, Wong, Lynette M, Sholl, Thorsten M, Schlaeger, Roderick T, Bronson, Lucian R, Chirieac, Monte M, Winslow, Marcia C, Haigis, Carla F, Kim   +18 more
openaire   +2 more sources

Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology

Фармакокинетика и Фармакодинамика, 2023
The interaction of the neurotrophin BDNF dipeptide mimetic, compound GSB-106, with the tyrosine kinase TrkB receptor specific for the fullsized neurotrophin was studied using surface plasmon resonance.
A. V. Tarasiuk, Y. V. Mezentsev, O. V. Gnedenko, P. Yu. Povarnina, A. S. Ivanov   +4 more
doaj   +1 more source

Receptor-Independent Anti-Ferroptotic Activity of TrkB Modulators

International Journal of Molecular Sciences, 2022
Dysregulated brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB) signalling is implicated in several neurodegenerative diseases, including Alzheimer’s disease. A failure of neurotrophic support may participate in neurodegenerative mechanisms, such as ferroptosis, which has likewise been implicated in this disease class.
Md. Jakaria, Abdel A. Belaidi, Adam Southon, Krista A. Dent, Darius J. R. Lane, Ashley I. Bush, Scott Ayton   +6 more
openaire   +3 more sources

TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets [PDF]

Journal of Neurology and Neuromedicine, 2016
Fil: Cragnolini, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales.
Danelon, Víctor, Cragnolini, Andrea Beatriz, Masco, Daniel Hugo   +2 more
openaire   +3 more sources

TrkB Receptor Ligands Promote Activity-Dependent Inhibitory Synaptogenesis [PDF]

The Journal of Neuroscience, 2000
Organotypic cerebellar cultures derived from newborn mice were simultaneously exposed to activity-blocking agents and neurotrophins for 2 weeks. Activity-blocked explants treated with the TrkB receptor ligands BDNF and neurotrophin-4 (NT-4) developed a full complement of Purkinje cell inhibitory axosomatic synapses, as defined ultrastructurally, and ...
F J, Seil, R, Drake-Baumann
openaire   +2 more sources

Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells. [PDF]

PLoS ONE, 2014
TrkB mediates the effects of brain-derived neurotrophic factor (BDNF) in neuronal and nonnneuronal cells. Based on recent reports that TrkB can also be transactivated through epidermal growth-factor receptor (EGFR) signaling and thus regulates migration ...
Rudolf Götz, Michael Sendtner
doaj   +1 more source

A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives

Frontiers in Molecular Neuroscience, 2023
IntroductionThe neurotrophin system plays a pivotal role in the development, morphology, and survival of the nervous system, and its dysregulation has been manifested in numerous neurodegenerative and neuroinflammatory diseases.
Daniele Narducci, Despoina Charou, Despoina Charou, Thanasis Rogdakis, Thanasis Rogdakis, Ioanna Zota, Ioanna Zota, Vivi Bafiti, Maria Zervou, Theodora Katsila, Achille Gravanis, Achille Gravanis, Kyriakos C. Prousis, Ioannis Charalampopoulos, Ioannis Charalampopoulos, Theodora Calogeropoulou   +15 more
doaj   +1 more source

Temporal Lobe Epilepsy and the BDNF Receptor, TrkB [PDF]

Epilepsia, 2010
Abstract Actions of estrogen and progesterone have been used to explain the changes in seizure frequency or severity in women with catamenial epilepsy. An alternative hypothesis is that BDNF is responsible, because estrogen causes an increase in BDNF expression that can have both acute effects on excitability and delayed, indirect ...
James O. McNamara, Helen E. Scharfman
openaire   +1 more source

Appetite enhancement and weight gain by peripheral administration of TrkB agonists in non-human primates. [PDF]

PLoS ONE, 2008
Loss of function mutations in the receptor tyrosine kinase TrkB pathway resulted in hyperphagia and morbid obesity in human and rodents. Conversely, peripheral or central stimulation of TrkB by its natural ligands BDNF or NT4 reduced body weight and food
John C Lin, David Tsao, Paul Barras, Raul A Bastarrachea, Bob Boyd, Joyce Chou, Rodnie Rosete, Hua Long, Alison Forgie, Yasmina Abdiche, Jeanette Dilley, Jennifer Stratton, Carlos Garcia, David L Sloane, Anthony G Comuzzie, Arnon Rosenthal   +15 more
doaj   +1 more source