Results 191 to 200 of about 40,205 (225)

Advances in acupuncture modulation of signaling pathways for epilepsy treatment: A review. [PDF]

Medicine (Baltimore)
Meng P, Wang X, Yang W, Jiang Y, Cheng W, Zhang Q.   +5 more
europepmc   +1 more source

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Truncated TrkB: Beyond a dominant negative receptor

Cytokine and Growth Factor Reviews, 2012
BDNF activates trkB receptors to regulate neuronal survival, differentiation, and proliferation. Mutations in the BDNF gene, altered BDNF expression, and altered trkB expression are associated with degenerative and psychiatric disorders. The full-length trkB receptor (trkB.tk(+)) undergoes autophosphorylation to activate intracellular signaling ...
exaly   +3 more sources

Targeting TrkB neurotrophin receptor to treat depression

Expert Opinion on Therapeutic Targets, 2008
An increasing number of findings point out the key role of the BDNF (brain-derived neurotrophic factor) receptor, tyrosine kinase receptor B (TrkB), in the regulation of antidepressant drug actions. Therefore, targeting TrkB receptors might be a rational strategy to develop novel antidepressant drugs.In this review we will discuss several approaches to
Tomi, Rantamäki, Eero, Castrén
openaire   +2 more sources

Neurotrophin-evoked rapid excitation through TrkB receptors

Nature, 1999
Neurotrophins are a family of structurally related proteins that regulate the survival, differentiation and maintenance of function of different populations of peripheral and central neurons. They are also essential for modulating activity-dependent neuronal plasticity. Here we show that neurotrophins elicit action potentials in central neurons.
K W, Kafitz, C R, Rose, H, Thoenen, A, Konnerth   +3 more
openaire   +2 more sources

Gangliosides prevent excitotoxicity through activation of TrkB receptor

Neurotoxicity Research, 2002
Gangliosides protect cerebellar granule cells from excitotoxicity; however, their mechanism of action remains to be fully characterized. GM1 ganglioside has been shown to activate Trk, the tyrosine kinase receptor implicated in the neuroprotective properties of the neurotrophins. In these studies, we used primary cultures of cerebellar granule cells to
Alessia, Bachis, Stuart J, Rabin, Marina, Del Fiacco, Italo, Mocchetti   +3 more
openaire   +2 more sources

Adenosine A2a receptors modulate TrkB receptor-dependent respiratory plasticity in neonatal rats

Respiratory Physiology & Neurobiology, 2021
Neuroplasticity is a fundamental property of the respiratory control system, enabling critical adaptations in breathing to meet the challenges, but little is known whether neonates express neuroplasticity similar to adults. We tested the hypothesis that, similar to adults, tyrosine receptor kinase B (TrkB) or adenosine A2a receptor activation in ...
Stephen M. Johnson, Ranveer M.S. Vasdev, McKayla M. Miller, Tracy L. Baker, Jyoti J. Watters   +4 more
openaire   +2 more sources

Stress Diminishes BDNF-stimulated TrkB Signaling, TrkB-NMDA Receptor Linkage and Neuronal Activity in the Rat Brain

Neuroscience, 2021
Exposure to intense or repeated stressors can lead to depression or post-traumatic stress disorder (PTSD). Neurological changes induced by stress include impaired neurotrophin signaling, which is known to influence synaptic integrity and plasticity. The present study used an ex vivo approach to examine the impact of acute or repeated stress on BDNF ...
Siobhan, Robinson, Allison S, Mogul, Elisa M, Taylor-Yeremeeva, Amber, Khan, Anthony D, Tirabassi, Hoau-Yan, Wang   +5 more
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BDNF and its TrkB receptor in human fracture healing

Annals of Anatomy - Anatomischer Anzeiger, 2014
Fracture healing is a physiological process of repair which proceeds in stages, each characterized by a different predominant tissue in the fracture gap. Matrix reorganization is regulated by cytokines and growth factors. Neurotrophins and their receptors might be of importance to osteoblasts and endothelial cells during fracture healing.
Olaf, Kilian, Sonja, Hartmann, Nicole, Dongowski, Srikanth, Karnati, Eveline, Baumgart-Vogt, Frauke V, Härtel, Thomas, Noll, Reinhard, Schnettler, Katrin Susanne, Lips   +8 more
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The neurotrophin receptor TrkB is colocalized to mitochondrial membranes

The International Journal of Biochemistry & Cell Biology, 2006
The transmembrane tyrosine-specific protein kinase TrkB has been shown to serve as a receptor for the neurotrophic factors BDNF and NT-4. Neurotrophin binding to TrkB isoformes mediates many intracellular signaling pathways, including calcium signalling.
Falk R, Wiedemann, Detlef, Siemen, Christian, Mawrin, Thomas F, Horn, Knut, Dietzmann   +4 more
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