Results 51 to 60 of about 40,205 (225)

Mice with a conditional deletion of the neurotrophin receptor TrkB are dwarfed, and are similar to mice with a MAPK14 deletion. [PDF]

PLoS ONE, 2013
Long bone growth results from ordered chondrocyte development within the cartilagenous growth plate. Chondrocytes are recruited from a resting pool to proliferate along the long axis of the bone, until various signals trigger differentiation and ...
Michele R Hutchison
doaj   +1 more source

Compounds originating from the edible mushroom Auricularia auricula-judae inhibit tropomyosin receptor kinase B activity

Heliyon, 2023
Tropomyosin receptor kinase B (TrkB) serves as a pivotal factor in various cancers. To identify novel natural compounds with TrkB-inhibiting properties, a screening approach was applied using extracts from a collection of wild and cultivated mushroom ...
Orr Shahar, Idan Pereman, Hazem Khamisie, Nirit Ezov, Ofer Danay, Ali Khattib, Ron schweitzer, Soliman Khatib, Jamal Mahajna   +8 more
doaj   +1 more source

Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling [PDF]

Developmental Cell, 2015
Recent studies in humans and in genetic mouse models have identified Slit- and NTRK-like family (Slitrks) as candidate genes for neuropsychiatric disorders. All Slitrk isotypes are highly expressed in the CNS, where they mediate neurite outgrowth, synaptogenesis, and neuronal survival.
Song, Minseok, Giza, Joanna, Proenca, Catia C., Jing, Deqiang, Elliott, Mark, Dincheva, Iva, Shmelkov, Sergey V., Kim, Jihye, Schreiner, Ryan, Huang, Shu-Hong, Castren, Eero, Prekeris, Rytis, Hempstead, Barbara L., Chao, Moses V., Dictenberg, Jason B., Rafii, Shahin, Chen, Zhe-Yu, Rodriguez-Boulan, Enrique, Lee, Francis S.   +18 more
openaire   +3 more sources

Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. [PDF]

, 2017
Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft ...
Chang, Ting-Ya, Chang, Ya-Chu, Chen, Chen, Cheng, Pei-Lin, Guo, Chin-Lin, Lee, Min, Lu, Chi-Huan, Lu, Shao-Tzu, Wang, Aijun, Wang, De-Yao   +9 more
core   +2 more sources

Involvement of BDNF Receptor TrkB in Spatial Memory Formation [PDF]

Learning & Memory, 2003
The N-methyl-D-aspartate (NMDA) receptors are involved in long-term potentiation (LTP), and are phosphorylated by several tyrosine kinases including a Src-family tyrosine kinase Fyn. Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which also enhances hippocampal synaptic transmission and efficacy by increasing NMDA receptor activity.
Makoto, Mizuno, Kiyofumi, Yamada, Jue, He, Akira, Nakajima, Toshitaka, Nabeshima   +4 more
openaire   +2 more sources

The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice. [PDF]

, 2018
Zinc (Zn2+) is a pleiotropic modulator of the neuronal and brain activity. The disruption of intraneuronal Zn2+ levels triggers neurotoxic processes and affects neuronal functioning.
Bomba, Manuela, Castelli, Vanessa, Castelli, Vanessa, Cimini, Annamaria, d'Aurora, Marco, Delli Pizzi, Stefano, Frazzini, Valerio, Gatta, Valentina, Granzotto, Alberto, Iorio, Mariangela, Massetti, Noemi, Mosca, Alessandra, Punzi, Miriam, Sensi, Stefano L   +13 more
core   +3 more sources

ξUp-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study

Journal of Neuroinflammation, 2011
Background During inflammation, immune cells accumulate in damaged areas and release pro-inflammatory cytokines and neurotrophins. Brain-derived neurotrophic factor (BDNF) plays a neuromodulatory role in spinal cord dorsal horn via the post-synaptic ...
Wang Hung-Li, Ro Long-Sun, Lin Ya-Tin, Chen Jin-Chung   +3 more
doaj   +1 more source

Expression of Neurotrophins and Their Receptors Tropomyosin-related kinases (Trk) under Tension-stress during Distraction Osteogenesis [PDF]

, 2006
The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation.
Aiga, Ayako, Asaumi, Koji, Kadota, Hiroaki, Lee, You Jin, Mitani, Shigeru, Ozaki, Toshifumi, Takigawa, Masaharu   +6 more
core   +1 more source

TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

Frontiers in Molecular Neuroscience, 2019
The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzheimer’s disease (AD), which may compromise the function of BDNF upon neuronal activity and survival.
João Fonseca-Gomes, João Fonseca-Gomes, André Jerónimo-Santos, André Jerónimo-Santos, Angelina Lesnikova, Plinio Casarotto, Eero Castrén, Ana M. Sebastião, Ana M. Sebastião, Maria J. Diógenes, Maria J. Diógenes   +10 more
doaj   +1 more source

α2-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling

Frontiers in Cell and Developmental Biology, 2020
Adrenergic signaling is a well-known input into pancreatic islet function. Specifically, the insulin-secreting islet β cell expresses the Gi/o-linked α2-adrenergic receptor, which upon activation suppresses insulin secretion.
Michael A. Kalwat, Zhimin Huang, Derk D. Binns, Kathleen McGlynn, Melanie H. Cobb   +4 more
doaj   +1 more source