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Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis. [PDF]
Proc Natl Acad Sci U S A, 2016 Significance Most previous work on endocytosis (the way cells ingest particles) has focused on engulfment of spherical targets. However, this is rarely relevant outside the laboratory, where cells must engulf a huge variety of target shapes, from capped ...
Richards DM, Endres RG.
europepmc +7 more sources
Receptor-Mediated Endocytosis in the Proximal Tubule. [PDF]
Annu Rev Physiol, 2017 Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical endocytosis of filtered proteins and small bioactive molecules from the glomerular ultrafiltrate to maintain essentially protein-free urine. Compromise of this pathway results in low molecular weight (LMW) proteinuria that can progress to end-stage kidney disease ...
Eshbach ML, Weisz OA.
europepmc +5 more sources
Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics [PDF]
International Journal of Cell Biology, 2013 Transport of macromolecules across the blood-brain-barrier (BBB) requires both specific and nonspecific interactions between macromolecules and proteins/receptors expressed on the luminal and/or the abluminal surfaces of the brain capillary endothelial ...
Guangqing Xiao, Liang-Shang Gan
doaj +3 more sources
ORAI channels are critical for receptor-mediated endocytosis of albumin. [PDF]
Nat Commun, 2017 Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms.
Zeng B +17 more
europepmc +2 more sources
Mechanics of receptor-mediated endocytosis. [PDF]
Proceedings of the National Academy of Sciences, 2005 Most viruses and bioparticles endocytosed by cells have characteristic sizes in the range of tens to hundreds of nanometers. The process of viruses entering and leaving animal cells is mediated by the binding interaction between ligand molecules on the viral capid and their receptor molecules on the cell membrane.
Gao, H., Shi, W., Freund, L.
semanticscholar +4 more sources
European Journal of Cell Biology, 2022 The role of the actin cytoskeleton during receptor-mediated endocytosis (RME) has been well characterized in yeast for many years. Only more recently has the interplay between the actin cytoskeleton and RME been extensively explored in mammalian cells ...
Garett Armstrong, Michael F. Olson
doaj +2 more sources
A role for myocilin in receptor-mediated endocytosis. [PDF]
PLoS ONE, 2013 Myocilin is a broadly expressed protein that when mutated uniquely causes glaucoma. While no function has been ascribed to explain focal disease, some properties of myocilin are known.
Brian S McKay +5 more
doaj +2 more sources
A "ligand-targeting" peptide-drug conjugate: Targeted intracellular drug delivery by VEGF-binding helix-loop-helix peptides via receptor-mediated endocytosis. [PDF]
PLoS ONE, 2021 As a new alternative to antibody-drug conjugates, we generated "ligand-targeting" peptide-drug conjugates (PDCs), which utilize receptor-mediated endocytosis for targeted intracellular drug delivery.
Masataka Michigami +5 more
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Receptor-mediated endocytosis. [PDF]
Journal of Clinical Investigation, 1986 Philip D. Stahl, Alan L. Schwartz
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