Different contributions of clathrin- and caveolae-mediated endocytosis of vascular endothelial cadherin to lipopolysaccharide-induced vascular hyperpermeability. [PDF]
PLoS ONE, 2014 Vascular hyperpermeability induced by lipopolysaccharide (LPS) is a common pathogenic process in cases of severe trauma and sepsis. Vascular endothelial cadherin (VE-cad) is a key regulatory molecule involved in this process, although the detailed ...
Ye Zhang +4 more
doaj +1 more source
Rapid insulin-dependent endocytosis of the insulin receptor by caveolae in primary adipocytes. [PDF]
PLoS ONE, 2009 BACKGROUND:The insulin receptor is localized in caveolae and is dependent on caveolae or cholesterol for signaling in adipocytes. When stimulated with insulin, the receptor is internalized.
Siri Fagerholm +4 more
doaj +1 more source
Rapid Clathrin-Mediated Uptake of Recombinant α-Gal-A to Lysosome Activates Autophagy
Biomolecules, 2020 Enzyme replacement therapy (ERT) with recombinant alpha-galactosidase A (rh-α-Gal A) is the standard treatment for Fabry disease (FD). ERT has shown a significant impact on patients; however, there is still morbidity and mortality in FD, resulting in ...
Margarita M. Ivanova +5 more
doaj +1 more source
Internalization mechanisms of the epidermal growth factor receptor after activation with different ligands. [PDF]
PLoS ONE, 2013 The epidermal growth factor receptor (EGFR) regulates normal growth and differentiation, but dysregulation of the receptor or one of the EGFR ligands is involved in the pathogenesis of many cancers.
Lasse Henriksen +4 more
doaj +1 more source
Effects of ligand distribution on receptor-diffusion-mediated cellular uptake of nanoparticles [PDF]
Royal Society Open Science, 2017 Biophysical-factor-dependent cellular uptake of nanoparticles (NPs) through receptor-diffusion-mediated endocytosis bears significance in pathology, cellular immunity and drug-delivery systems. Advanced nanotechnology of NP synthesis provides methods for
Long Li, Yudie Zhang, Jizeng Wang
doaj +1 more source
Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis [PDF]
FEMS Microbiology Letters, 2001 An increasing number of pathogens or their toxins appear to utilize glycosylphosphatidylinositol(GPI)-anchored receptors to trigger entry into immune and other host cells. Since these receptors have no transmembrane and intracellular moieties, how endocytosis is initiated is unclear.
J S, Shin, S N, Abraham
openaire +3 more sources
Interaction among Saccharomyces cerevisiae pheromone receptors during endocytosis
Biology Open, 2014 This study investigates endocytosis of Saccharomyces cerevisiae α-factor receptor and the role that receptor oligomerization plays in this process. α-factor receptor contains signal sequences in the cytoplasmic C-terminal domain that are essential for ...
Chien-I Chang +2 more
doaj +1 more source
Chemical Inhibitors of Dynamin Exert Differential Effects in VEGF Signaling
Cells, 2021 VEGFR2 is the main receptor and mediator of the vasculogenic and angiogenic activity of VEGF. Activated VEGFR2 internalizes through clathrin-mediated endocytosis and macropinocytosis.
Dimitris Basagiannis +5 more
doaj +1 more source
Mutations in human dynamin block an intermediate stage in coated vesicle formation [PDF]
, 1993 The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to ...
Damke, Hanna +5 more
core +3 more sources
Journal of Cell Biology, 1983 At 4 degrees C transferrin bound to receptors on the reticulocyte plasma membrane, and at 37 degrees C receptor-mediated endocytosis of transferrin occurred. Uptake at 37 degrees C exceeded binding at 4 degrees C by 2.5-fold and saturated after 20-30 min.
C. Harding, J. Heuser, P. Stahl
semanticscholar +1 more source