Endocytic Regulation of Voltage-Dependent Potassium Channels in the Heart
Journal of Pharmacological Sciences, 2012 Understanding the regulation of cardiac ion channels is critical for the prevention of arrhythmia caused by abnormal excitability. Ion channels can be regulated by a change in function (qualitative) and a change in number (quantitative).
Kuniaki Ishii, Ikuo Norota, Yutaro Obara
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The role of cellular adhesion molecules in virus attachment and entry [PDF]
, 2015 As obligate intracellular parasites, viruses must traverse the host-cell plasma membrane to initiate infection. This presents a formidable barrier, which they have evolved diverse strategies to overcome.
Bhella, David
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IRR is involved in glucose-induced endocytosis after insulin secretion
Journal of Pharmacological Sciences, 2019 Endocytosis after insulin secretion plays a pivotal role in the regulation of insulin secretion in pancreatic β-cells. Our recent study suggested that EPI64, a GTPase activating protein for Rab27a, contributes to the regulation of glucose-induced ...
Mami Yamaoka +6 more
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Real-time visualization and modulation of endocytic dynamics in osteocytes in vivo. [PDF]
Sci RepEndocytosis is a critical cellular process involved in many physiological functions, including mechanotransduction. Recent advancements in intravital imaging have led to in vivo analysis of endocytosis, and these tools can now be translated to study the ...
Matthews MD +6 more
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Systemic Glycosaminoglycan Clearance by HARE/Stabilin-2 Activates Intracellular Signaling
Cells, 2020 Scavenger receptors perform essential functions, critical to maintaining mammalian physiologic homeostasis by continuously clearing vast numbers of biomolecules from blood, interstitial fluid and lymph. Stabilin-2 (Stab2) and the Hyaluronic Acid Receptor
Paul H. Weigel
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Human SCARB2-mediated entry and endocytosis of EV71. [PDF]
PLoS ONE, 2012 Enterovirus (EV) 71 infection is known to cause hand-foot-and-mouth disease (HFMD) and in severe cases, induces neurological disorders culminating in fatality.
Yi-Wen Lin +9 more
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Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]
, 2006 Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
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Approaches to Visualising Endocytosis of LDL-Related Lipoproteins
Biomolecules, 2022 Endocytosis is the process by which molecules are actively transported into cells. It can take on a variety of forms depending on the cellular machinery involved ranging from specific receptor-mediated endocytosis to the less selective and actin-driven ...
Halima Siddiqui +3 more
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Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells [PDF]
, 2015 Cytotoxic lymphocytes share the presence of the activating receptor NK receptor group 2, member D (NKG2D) and the signaling-competent adaptor DNAX-activating protein 10 (DAP10), which together play an important role in antitumor immune surveillance ...
CAPUANO, CRISTINA +9 more
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IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
eLife, 2018 Insulin-like growth factor-I receptor (IGF-IR) preferentially regulates the long-term IGF activities including growth and metabolism. Kinetics of ligand-dependent IGF-IR endocytosis determines how IGF induces such downstream signaling outputs.
Yosuke Yoneyama +9 more
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