Results 81 to 90 of about 220,108 (349)

Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis

Journal of Lipid Research, 2007
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that regulates low density lipoprotein receptor (LDLR) protein levels. The mechanisms of this action, however, remain to be defined.
Yue-Wei Qian, Robert J. Schmidt, Youyan Zhang, Shaoyou Chu, Aimin Lin, He Wang, Xiliang Wang, Thomas P. Beyer, William R. Bensch, Weiming Li, Mariam E. Ehsani, Deshun Lu, Robert J. Konrad, Patrick I. Eacho, David E. Moller, Sotirios K. Karathanasis, Guoqing Cao   +16 more
doaj   +1 more source

Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor

Cell Communication and Signaling, 2020
Background Lymphotoxin β receptor (LTβR) is a member of tumor necrosis factor receptor (TNFR) superfamily which regulates the immune response. At the cellular level, upon ligand binding, the receptor activates the pro-inflammatory NF-κB and AP-1 pathways.
Małgorzata Maksymowicz, Marta Miączyńska, Magdalena Banach-Orłowska   +2 more
doaj   +1 more source

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT(3)) receptors ...
Aapro, Ahern, Amy Alexander, Andrew J. Samson, Bearcroft, Bertrand, Bertrand, Bhattacharyya, Boyd, Chanrion, Chen, Chen, Christopher Moffat, Christopher N. Connolly, Connolly, Craig, Faerber, Freeman, Galligan, Guthrie, Hagbom, Hanley, Hansen, Hothersall, Huang, Ilegems, J. Daniel Hothersall, Jiménez-Trejo, Karen A. Bollan, Kittler, Kondaurova, Lau, Lee, Linder, Liu, Liu, Lummis, McKinnon, Mercado, Minami, Mnie-Filali, Muchatuta, Niesler, Riad, Rojas, Schlag, Spiller, Stratz, Tao-Cheng, Turvill, Vikenes, Wade, Wesseldijk, Whalen, Yasuda   +54 more
core   +2 more sources

Double‐Stranded DNA Reduces dsRNA Degradation in the Saliva and Significantly Enhanced RNAi‐Mediated Gene Silencing in Halyomorpha halys

Advanced Biology, EarlyView.
The invasive pest Halyomorpha halys causes significant crop losses requiring innovative pest control strategies such as RNA interference (RNAi). However, oral RNAi is largely ineffective in H. halys. This study shows that double‐stranded DNA (dsDNA) stabilizes dsRNA in saliva by inhibiting a highly expressed nuclease.
Venkata Partha Sarathi Amineni, Georg Petschenka, Aline Koch   +2 more
wiley   +1 more source

Receptor-Mediated Endocytosis in Plants is Energetically Possible [PDF]

Plant Physiology, 1988
A detailed examination of the arguments of Cram (1980 New Phytol 84: 1-17) against the uptake of major nutrients in plants by endocytosis shows that the arguments do not exclude the possibility of receptor-mediated endocytosis.
M J Saxton, R W Breidenbach
openaire   +3 more sources

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells [PDF]

, 2018
Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression.
Acconcia, Acconcia, Acerbi, Adlanmerini, Alfredo Cáceres, Ambrose, Andrés M. Toscani, Arjonen, Arnal, Axelrod, Axelrod, Bacia, Bae, Barabas, Bates, Bermudez-Hernandez, Bonifacino, Bradford, Cancer Genome Atlas Network, Caswell, Cerami, Chaumet, Chung, Ciriello, Ciriello, Correia, Cosker, Cosker, Couse, Cox, Dante R. Chialvo, De Franceschi, Debnath, Degasperi, Delcroix, Dozynkiewicz, Dunn, Eirew, Federico Coluccio Leskow, Fernando D. Stefani, Gao, Gao, Ghajar, Gillespie, Gould, Graham, Grant, Han, Han, Hartley, He, Heery, Helleman, Hernández, Hines, Honerkamp-Smith, Ianina L. Violi, Jeselsohn, Johnson, Jonathon N. Lakins, Kate Thi, Kisler, La Rosa, Letoha, Levin, Li, Long, Lu, Lu, Luciano A. Masullo, Luzio, Mak, Marina Simian, Marino, Matthew G. Rubashkin, Mayor, Mayor, Małecki, McDonough, Mina J. Bissell, Moreno-Layseca, Nam, Nardone, Nicovich, Ovesný, Pedram, Pereira, Pietras, Pontiggia, Razandi, Reid, Rocío G. Sampayo, Rust, Savkur, Schindelin, Schlegel, Skliris, Solowska, Su, Sung, Takahashi, Tiwari, Totta, Totta, Upla, Valerie M. Weaver, van de Linde, Vanlandingham, Wang, Waxmonsky, William C. Hines, Yao   +111 more
core   +2 more sources

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Endomucin selectively regulates vascular endothelial growth factor receptor-2 endocytosis through its interaction with AP2

Cell Communication and Signaling
The endothelial glycocalyx, located at the luminal surface of the endothelium, plays an important role in the regulation of leukocyte adhesion, vascular permeability, and vascular homeostasis.
Issahy Cano, Melissa Wild, Urvi Gupta, Suman Chaudhary, Yin Shan Eric Ng, Magali Saint-Geniez, Patricia A. D’Amore, Zhengping Hu   +7 more
doaj   +1 more source

Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling. [PDF]

PLoS ONE, 2011
Endocytosis of tyrosine kinase receptors can influence both the duration and the specificity of the signal emitted. We have investigated the mechanisms of internalization of fibroblast growth factor receptor 3 (FGFR3) and compared it to that of FGFR1 ...
Ellen Margrethe Haugsten, Malgorzata Zakrzewska, Andreas Brech, Sascha Pust, Sjur Olsnes, Kirsten Sandvig, Jørgen Wesche   +6 more
doaj   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source