Results 131 to 140 of about 3,511,004 (317)

The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95

, 2003
Peter K. Todd, Kenneth J. Mack, James S. Malter   +2 more
openalex   +1 more source

Role of Toll-like receptors in the development of immunotolerance mediated by probiotics [PDF]

, 2010
Carolina Gómez‐Llorente, Sergio García Muñoz, Ángel Gil   +2 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

In silico structural and docking models of dipteran FXPRLamide neuropeptides support ligand-receptor coevolution and suggest mechanisms for ligand bias. [PDF]

PLoS One
Farris SM.
europepmc   +1 more source

Interdependent Serotonin Transporter and Receptor Pathways Regulate S100A4/Mts1, a Gene Associated With Pulmonary Vascular Disease [PDF]

, 2005
Allan Lawrie, Edda Spiekerkoetter, Eliana C. Martinez, Noona Ambartsumian, W. John Sheward, Margaret R. MacLean, Anthony J. Harmar, Ann-Marie Schmidt, Eugene Lukanidin, Marlene Rabinovitch   +9 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

From Single Ligand-Receptor Bond Strength to Collective Avidity: Mechanics-Guided Superselective Nanoparticle Adhesion to Biological Membranes. [PDF]

Langmuir
Hamzeh M, Mirahsani S, Ahmadpoor F, Farokhirad S.   +3 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Lipoprotein Accumulation in Macrophages via Toll-Like Receptor-4–Dependent Fluid Phase Uptake

, 2009
Soo-Ho Choi, Richard Harkewicz, Jee Hyun Lee, Agnès Boullier, Felicidad Almazan, Andrew C. Li, Joseph L. Witztum, Yun Soo Bae, Yury I. Miller   +8 more
openalex   +1 more source

Ecto-5'-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions [PDF]

, 2013
Elisabete Augusto, Marco Matos, Jean Sévigny, Ali El‐Tayeb, Margaret S. Bynoe, Christa E. Müller, Rodrigo A. Cunha, Jiang‐Fan Chen   +7 more
openalex   +1 more source