Results 261 to 270 of about 3,511,004 (317)
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Pharmaceutica Acta Helvetiae, 2000
The identification of new binding sites raises the problem of defining their role, if any. At times they are shown to be pharmacological receptors, in a strict sense, as they fulfill certain requirements, and a precise physiological role and function, and an endogenous ligand (neurotransmitter) are discovered.
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The identification of new binding sites raises the problem of defining their role, if any. At times they are shown to be pharmacological receptors, in a strict sense, as they fulfill certain requirements, and a precise physiological role and function, and an endogenous ligand (neurotransmitter) are discovered.
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Science Signaling, 2008
Toll-like receptors recognize molecules associated with pathogens and initiate inflammatory responses. For example, Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), an intermediate viral replication. The TLR3 ectodomain binds as a dimer to dsRNA, but the molecular basis for signaling remains unclear.
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Toll-like receptors recognize molecules associated with pathogens and initiate inflammatory responses. For example, Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), an intermediate viral replication. The TLR3 ectodomain binds as a dimer to dsRNA, but the molecular basis for signaling remains unclear.
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Receptor–receptor interactions within receptor mosaics. Impact on neuropsychopharmacology
Brain Research Reviews, 2008Future therapies for diseases associated with altered dopaminergic signaling, including Parkinson's disease, schizophrenia and drug addiction or drug dependence may substantially build on the existence of intramembrane receptor-receptor interactions within dopamine receptor containing receptor mosaics (RM; dimeric or high-order receptor oligomers ...
Fuxe K +14 more
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Receptor Regulation and Receptor-Receptor Communication
1987As recently as five years ago, what one might term the “grind and bind era” of receptor studies was still in full bloom; and a large number of studies were focussed on determining receptor affinities and numbers under a variety of physiologic situations.
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Trends in Pharmacological Sciences, 1997
While regulation of receptor function is known to occur at many levels (e.g. transcriptional, post-translational), it is generally perceived that a tissue either expresses or does not express a particular receptor in an all-or-none fashion. Many pathological (e.g. tissue injury) and physiological (e.g.
L F, Donaldson +2 more
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While regulation of receptor function is known to occur at many levels (e.g. transcriptional, post-translational), it is generally perceived that a tissue either expresses or does not express a particular receptor in an all-or-none fashion. Many pathological (e.g. tissue injury) and physiological (e.g.
L F, Donaldson +2 more
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Angewandte Chemie International Edition in English, 1976
AbstractHormone receptors are proteins located on the cell membrane or in the cell cytoplasm. Their function is to recognize and bind the respective hormone; the biological action of the hormone originates from the hormone‐receptor complex. Specific receptors have been found for all known hormones. Monitoring the equilibration between hormone, receptor,
K, Lübke, E, Schillinger, M, Töpert
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AbstractHormone receptors are proteins located on the cell membrane or in the cell cytoplasm. Their function is to recognize and bind the respective hormone; the biological action of the hormone originates from the hormone‐receptor complex. Specific receptors have been found for all known hormones. Monitoring the equilibration between hormone, receptor,
K, Lübke, E, Schillinger, M, Töpert
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Scandinavian Journal of Gastroenterology, 1986
More insight into the biochemical structure and operation of the somatostatin receptor(s) has been gained in recent years from several approaches. The minimal active structure of the receptor(s) has been identified, and active minisomatostatins have been synthesized.
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More insight into the biochemical structure and operation of the somatostatin receptor(s) has been gained in recent years from several approaches. The minimal active structure of the receptor(s) has been identified, and active minisomatostatins have been synthesized.
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Current Protocols in Pharmacology, 1998
AbstractReceptor theory assigns mathematical rules to biological systems in order to quantify drug effects and define what biological systems can and cannot do, leading to the design of experiments that may further modify the model. Drug receptor theory also furnishes the tools for quantifying the activity of drugs in a system‐independent manner ...
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AbstractReceptor theory assigns mathematical rules to biological systems in order to quantify drug effects and define what biological systems can and cannot do, leading to the design of experiments that may further modify the model. Drug receptor theory also furnishes the tools for quantifying the activity of drugs in a system‐independent manner ...
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