Results 371 to 380 of about 7,559,498 (434)
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Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002
Anandamide (N -arachidonoyl-ethanolamine, AEA) was the first endogenous ligand of cannabinoid receptors to be discovered. Yet, since early studies, AEA appeared to exhibit also some effects that were not mediated by cannabinoid CB(1) or CB(2) receptors.
Di Marzo V +4 more
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Anandamide (N -arachidonoyl-ethanolamine, AEA) was the first endogenous ligand of cannabinoid receptors to be discovered. Yet, since early studies, AEA appeared to exhibit also some effects that were not mediated by cannabinoid CB(1) or CB(2) receptors.
Di Marzo V +4 more
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A receptor-mediated pathway for cholesterol homeostasis.
Science, 1986In 1901 a physician, Archibald Garrod, observed a patient with black urine. He used this simple observation to demonstrate that a single mutant gene can produce a discrete block in a biochemical pathway, which he called an “inborn error of metabolism ...
M. Brown, J. Goldstein
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Cytokine & Growth Factor Reviews, 2001
Although chemokines were originally defined as host defense proteins it is now clear that their repertoire of functions extend well beyond this role. For example chemokines such as MGSA have growth regulatory properties while members of the CXC chemokine family can be mediators or inhibitors of angiogenesis and may be important targets for oncology ...
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Although chemokines were originally defined as host defense proteins it is now clear that their repertoire of functions extend well beyond this role. For example chemokines such as MGSA have growth regulatory properties while members of the CXC chemokine family can be mediators or inhibitors of angiogenesis and may be important targets for oncology ...
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Receptor–receptor interactions within receptor mosaics. Impact on neuropsychopharmacology
Brain Research Reviews, 2008Future therapies for diseases associated with altered dopaminergic signaling, including Parkinson's disease, schizophrenia and drug addiction or drug dependence may substantially build on the existence of intramembrane receptor-receptor interactions within dopamine receptor containing receptor mosaics (RM; dimeric or high-order receptor oligomers ...
Fuxe K +14 more
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Science, 1997A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR). When transfected with CAR complementary DNA, nonpermissive hamster cells became susceptible to coxsackie B virus attachment and infection ...
J. Bergelson +8 more
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Reviews in the Neurosciences, 2016
AbstractIntercellular and intracellular communication processes consist of signals and recognition/decoding apparatuses of these signals. In humans, the G protein-coupled receptor (GPCR) family represents the largest family of cell surface receptors.
Agnati, Luigi F. +4 more
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AbstractIntercellular and intracellular communication processes consist of signals and recognition/decoding apparatuses of these signals. In humans, the G protein-coupled receptor (GPCR) family represents the largest family of cell surface receptors.
Agnati, Luigi F. +4 more
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Receptor Regulation and Receptor-Receptor Communication
1987As recently as five years ago, what one might term the “grind and bind era” of receptor studies was still in full bloom; and a large number of studies were focussed on determining receptor affinities and numbers under a variety of physiologic situations.
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Bradykinin receptors and receptor ligands (with special emphasis on vascular receptors)
Regulatory Peptides, 1996Bradykinin and receptor ...
REGOLI, Domenico +7 more
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1992
Publisher Summary This chapter presents the pharmacodynamics of drug-receptor interactions. Because of the low concentration of drugs and receptors in the bloodstream and other biological fluids, the law of the mass action alone cannot account for the ability of small doses of structurally specific drugs to elicit a total response.
Richard B. Silverman, Mark W. Holladay
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Publisher Summary This chapter presents the pharmacodynamics of drug-receptor interactions. Because of the low concentration of drugs and receptors in the bloodstream and other biological fluids, the law of the mass action alone cannot account for the ability of small doses of structurally specific drugs to elicit a total response.
Richard B. Silverman, Mark W. Holladay
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The oxytocin receptor system: structure, function, and regulation.
Physiological Reviews, 2001The neurohypophysial peptide oxytocin (OT) and OT-like hormones facilitate reproduction in all vertebrates at several levels. The major site of OT gene expression is the magnocellular neurons of the hypothalamic paraventricular and supraoptic nuclei.
G. Gimpl, F. Fahrenholz
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