Results 161 to 170 of about 59,132 (205)

Modulation of Soluble Receptor for Advanced Glycation End Products Isoforms and Advanced Glycation End Products in Long-Living Individuals

Biomarkers in Medicine, 2021
Background: Circulating levels of soluble receptor for advanced glycation end products (sRAGE) and advanced glycation end products (AGEs) correlate with aging/cardiovascular risk, which is delayed in long-living individuals (LLIs). AGEs/sRAGE isoforms (cleaved RAGE [cRAGE] and secretory RAGE [esRAGE]) ratio is a valuable marker for disease risk ...
Francesco Scavello   +8 more
openaire   +2 more sources

Receptor for Advanced Glycation End Products: Dementia and Cognitive Impairment

Drug Research, 2023
AbstractThe pathophysiological processes of dementia and cognitive impairment are linked to advanced glycation end products (AGEs) and their receptor (RAGE).The neurofibrillary tangles (NFTs) of abnormally hyperphosphorylated tau protein and senile plaques (SPs), which are brought on by ...
Aditya, Singh   +7 more
openaire   +2 more sources

Advanced glycation end product ligands for the receptor for advanced glycation end products: biochemical characterization and formation kinetics

Analytical Biochemistry, 2004
Advanced glycation end products (AGEs) accumulate with age and at an accelerated rate in diabetes. AGEs bind cell-surface receptors including the receptor for advanced glycation end products (RAGE). The dependence of RAGE binding on specific biochemical characteristics of AGEs is currently unknown.
Valencia, J.V.   +6 more
openaire   +3 more sources

Understanding RAGE, the receptor for advanced glycation end products

Journal of Molecular Medicine, 2005
Advanced glycation end products (AGEs), S100/calgranulins, HMGB1-proteins, amyloid-beta peptides, and the family of beta-sheet fibrils have been shown to contribute to a number of chronic diseases such as diabetes, amyloidoses, inflammatory conditions, and tumors by promoting cellular dysfunction via binding to cellular surface receptors.
Angelika, Bierhaus   +7 more
openaire   +2 more sources

Receptor for advanced glycation end-products in neurodegenerative diseases

Reviews in the Neurosciences, 2015
AbstractThis review, for the first time, aims to summarize the current knowledge in the emerging field of RAGE (receptor for advanced glycation end-products) studies in neurodegeneration and neurodegenerative diseases. RAGE, a member of the multiligand cell surface immunoglobulin family, has been implicated in numerous pathological conditions – from ...
Judyta, Juranek   +3 more
openaire   +2 more sources

Advanced glycation end products inhibit proliferation and primary cilia formation of myoblasts through receptor for advanced glycation end products pathway

Biochemical and Biophysical Research Communications, 2023
The loss of skeletal muscle mass leads to various adverse conditions and shortened lifespan. The inhibition of myoblast proliferation is one of the causes that trigger muscle atrophy. Advanced glycation end products (AGEs) contribute to muscle atrophy.
Shinichiro Suzuki   +2 more
openaire   +2 more sources

Receptor for advanced glycation end products (RAGE) in atrial fibrillation

International Journal of Cardiology, 2013
with advanced heart failure. J Am Coll Cardiol 2006;48:2485–9. [9] Okonko DO, Grzeslo A, Witkowski T, et al. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency: FERRIC-HF: a randomized, controlled, observerblinded trial. JACC 2008;51:103.
Nitin, Mahajan, Veena, Dhawan
openaire   +2 more sources

Rage: A Novel Cellular Receptor for Advanced Glycation End Products

Diabetes, 1996
Exposure of proteins to reducing sugars results in nonenzymatic glycation with the ultimate formation of advanced glycation end products (AGEs). One means through which AGEs modulate cellular functions is through binding to specific cell surface acceptor molecules.
A M, Schmidt   +9 more
openaire   +2 more sources

Sulforaphane inhibits advanced glycation end product–induced pericyte damage by reducing expression of receptor for advanced glycation end products

Nutrition Research, 2014
Advanced glycation end products (AGEs) not only inhibit DNA synthesis but also play a role in diabetic retinopathy by evoking apoptosis and inflammation in retinal pericytes via interaction with a receptor for AGE (RAGE). Similarly, sulforaphane, which is a naturally occurring isothiocyanate that is found in widely consumed cruciferous vegetables ...
Sayaka, Maeda   +4 more
openaire   +2 more sources

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