Results 241 to 250 of about 2,183,179 (300)

The receptor tyrosine kinase ErbB2/HER2 governs CDK4 inhibitor sensitivity, timing, and irreversibility of the G1/S transition. [PDF]

J Biol Chem
Nagasato-Ichikawa A, Murakami K, Aoki K, Okada M.   +3 more
europepmc   +1 more source

Discoidin domain receptor tyrosine kinase 2: A new perspective on microenvironment remodeling and targeted therapy of solid tumors (Review). [PDF]

Oncol Lett
Lu T, Guo H, Gong H, Ma Y, Tian Y, Zhang D.   +5 more
europepmc   +1 more source

Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face. [PDF]

Dev Dyn
Hanne N, Hu D, Vidal-García M, Allen C, Shakir MB, Liu W, Hallgrímsson B, Marcucio R.   +7 more
europepmc   +1 more source

Tyrosine Kinase Receptors in Oncology [PDF]

International Journal of Molecular Sciences, 2020
Tyrosine kinase receptors (TKR) comprise more than 60 molecules that play an essential role in the molecular pathways, leading to cell survival and differentiation. Consequently, genetic alterations of TKRs may lead to tumorigenesis and, therefore, cancer development.
Alfredo Carrato, Javier Torres Jiménez, Juan José Soto Castillo   +2 more
exaly   +4 more sources

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Receptor tyrosine kinases

The FASEB Journal, 1992
A major process through which environmental information is transmitted into cells is via activation of protein tyrosine kinases. Receptor tyrosine kinases contain extracellular ligand recognition, single membrane spanning, and cytoplasmic protein tyrosine kinase domains. The cytoplasmic kinase core is flanked by regulatory segments,
D L, Cadena, G N, Gill
openaire   +2 more sources

Receptor tyrosine kinases and their targets

Current Opinion in Genetics & Development, 1994
One of the ways in which higher eukaryotes receive messages from the environment is via cell surface receptor tyrosine kinases. These are transmembrane proteins with an extracellular binding domain that specifies the growth factor with which it will interact, and an intracellular domain that encodes the tyrosine kinase.
openaire   +2 more sources

Receptor tyrosine kinase inhibitors in cancer

Cellular and Molecular Life Sciences, 2023
Targeted therapy is a new cancer treatment approach, involving drugs that particularly target specific proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are involved in promoting growth and proliferation, Therefore inhibiting these proteins could impede cancer progression.
Nasim, Ebrahimi, Elmira, Fardi, Hajarossadat, Ghaderi, Sahar, Palizdar, Roya, Khorram, Reza, Vafadar, Masoud, Ghanaatian, Fatemeh, Rezaei-Tazangi, Payam, Baziyar, Amirhossein, Ahmadi, Michael R, Hamblin, Amir Reza, Aref   +11 more
openaire   +2 more sources

Receptor tyrosine kinases and the regulation of hematopoiesis

Seminars in Immunology, 1995
The ongoing production of mature blood cells during the lifetime of an animal is vital for survival. Hematopoiesis is the complex process whereby a small population of pluripotential stem cells give rise to mature cell types with specialized functions.
R F, Paulson, A, Bernstein
openaire   +2 more sources