Results 11 to 20 of about 83 (72)

CGRP Receptor Antagonism and Migraine [PDF]

Neurotherapeutics, 2010
Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral nervous systems, consistent with control of vasodilatation, nociception, motor function, secretion, and olfaction. alphaCGRP is prominently localized in primary spinal afferent C and ADelta fibers of sensory ganglia, and betaCGRP is the main isoform in the enteric
Lars, Edvinsson, Tony W, Ho
openaire   +2 more sources

CGRP and CGRP receptors in human and rhesus monkey cerebellum [PDF]

The Journal of Headache and Pain, 2013
Background The cerebellum is classically considered mainly involved in motor processing, but recent studies have suggested several other functions, including pain processing. PET studies of acute migraine attacks have revealed activation of the cerebellum.
Eftekhari, S, Salvatore, CA, Connolly, BM, O’Malley, S, Miller, PJ, Zeng, Z, Edvinsson, L   +6 more
openaire   +1 more source

CGRP receptors and TRP channels in migraine [PDF]

The Journal of Headache and Pain, 2015
Calcitonin gene-related peptide (CGRP) seems to play a major role in migraine mechanism. Overwhelming data report the efficacy of small molecule CGRP receptor antagonists in the treatment of migraine attacks. If some CGRP receptor (CGRP-R) antagonists could theoretically cross the blood brain barrier (BBB) one of them, olcagepant, due to its peptoid ...
Geppetti, Pierangelo, Benemei, Silvia, De Cesaris, Francesco   +2 more
openaire   +2 more sources

[New therapeutic era for migraine attacks with recently approved monoclonal antibodies, ditans and gepants]. [PDF]

Rev Neurol
Mínguez-Olaondo A, López-Bravo A, Quintas S, Nieves-Castellanos C, Layos-Romero A, Belvís R, Irimia P, Díaz-Insa S.   +7 more
europepmc   +1 more source

Eficacia de la fotobiomodulación en el manejo del dolor agudo en trastornos temporomandibulares: Estudio de serie de casos. [PDF]

Rev Cient Odontol (Lima)
Villafañe A, Hernández-Andara A, Vargas A, Brito A, Manresa C, Villarroel-Dorrego M.   +5 more
europepmc   +1 more source

Invited Lectures : Overviews Purinergic signalling: past, present and future. [PDF]

Purinergic Signal, 2006
europepmc   +1 more source

peptide (CGRP) receptors in

peptide (CGRP) receptors in
openaire   +1 more source

CGRP and Its Receptors

Headache, 2017
The calcitonin gene‐related peptide (CGRP) neuropeptide system is an important but still evolving target for migraine. A fundamental consideration for all of the current drugs in clinical trials and for ongoing development in this area is the identity, expression pattern, and function of CGRP receptors because this knowledge ...
Christopher Walker, Debbie Hay
exaly   +3 more sources

CGRP Receptor Antagonists and Antibodies Against CGRP and Its Receptor in Migraine Treatment [PDF]

British Journal of Clinical Pharmacology, 2015
Recently developed calcitonin gene‐related peptide (CGRP) receptor antagonistic molecules have shown promising results in clinical trials for acute treatment of migraine attacks. Drugs from the gepant class of CGRP receptor antagonists are effective and do not cause vasoconstriction, one of the major limitations in the use of triptans.
Lars Edvinsson
exaly   +4 more sources

The activation of the CGRP receptor

Biochemical Society Transactions, 2013
The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR.
Barwell, James, Wheatley, Mark, Conner, Alex C, Taddese, Bruck, Vohra, Shabana, Reynolds, Christopher A, Poyner, David R   +6 more
openaire   +3 more sources