Results 31 to 40 of about 83 (72)
Some of the next articles are maybe not open access.
Recognizing the role of CGRP and CGRP receptors in migraine and its treatment
Cephalalgia, 2017Premise The brain and the sensory nervous system contain a rich supply of calcitonin gene-related peptide (CGRP) and CGRP receptor components. Clinical studies have demonstrated a correlation between CGRP release and acute migraine headache that led to the development of CGRP-specific drugs that either abort ...
Edvinsson, Lars, Warfvinge, Karin
openaire +3 more sources
CGRP Receptor Signalling Pathways
2018Calcitonin gene-related peptide (CGRP) is a promiscuous peptide, similar to many other members of the calcitonin family of peptides. The potential of CGRP to act on many different receptors with differing affinities and efficacies makes deciphering the signalling from the CGRP receptor a challenging task for researchers.Although it is not a typical G ...
openaire +2 more sources
CGRP receptors in the control of pain and inflammation
Current Opinion in Pharmacology, 2009Calcitonin gene related peptide (CGRP) has been proposed to contribute to pain transmission and inflammation and for these reasons to the mechanism of migraine. CGRP is, in fact, expressed in and released from a subset of polymodal primary sensory neurons of the trigeminal ganglion.
BENEMEI, SILVIA +3 more
openaire +3 more sources
CGRP receptor antagonists (gepants)
Small molecule calcitonin gene-related peptide (CGRP) receptor antagonists are commonly referred to as gepants. The first generation of gepants provided the first line of evidence of CGRP-mediated antimigraine medication in 2004-2011. However, further development was halted due to either lack of oral availability or concerns of hepatotoxicity.Samaira, Younis +3 more
openaire +2 more sources
Ectodomain Structures of the CGRP and AM Receptors
Current Protein & Peptide Science, 2013Receptor activity-modifying proteins (RAMPs) 1-3, which are classified as type I transmembrane proteins, serve as the partner proteins of several family B GPCRs for physiologically active peptides, including the calcitonin receptor- like receptor (CLR). The properties of the GPCRs are defined by the RAMP and peptide ligand combination.
Seisuke, Kusano, Shigeyuki, Yokoyama
openaire +2 more sources
Critical Care Management of Chimeric Antigen Receptor T-Cell Therapy Recipients
Ca-A Cancer Journal for Clinicians, 2022Sandrine Valadè +2 more
exaly
CGRP and the Calcitonin Receptor Are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons
Frontiers in Physiology, 2022Christopher Walker +2 more
exaly