Results 21 to 30 of about 83 (72)

CGRP receptor antagonists

Headache Currents, 2004
Calcitonin Gene‐Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine BACKGROUND: Calcitonin gene‐related peptide (CGRP) may have a causative role in migraine. We therefore hypothesized that a CGRP‐receptor antagonist might be effective in the treatment of migraine attacks.
BURGEY CHRISTOPHER S, DENG ZHENGWU J, NGUYEN DIEM N, PAONE DANIEL V, SHAW ANTHONY W, WILLIAMS THERESA M   +5 more
openaire   +10 more sources

Distribution of CGRP and CGRP receptor components in the rat brain

Cephalalgia, 2017
Background Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies.
Warfvinge, Karin, Edvinsson, Lars
openaire   +3 more sources

CGRP receptors: beyond the CGRP1–CGRP2 subdivision?

Trends in Pharmacological Sciences, 2001
In a recent TiPS article 1xThe molecular pharmacology of CGRP and related peptide receptor subtypes. Juaneda, C. et al. Trends Pharmacol. Sci. 2000; 21: 432–438Abstract | Full Text | Full Text PDF | PubMed | Scopus (131)See all References1, Juaneda and colleagues reviewed the molecular pharmacology of calcitonin gene-related peptide (CGRP) and related ...
D, Poyner, I, Marshall
openaire   +2 more sources

Pain pharmacology in migraine: focus on CGRP and CGRP receptors

Neurological Sciences, 2007
Over the last 100 years, the discovery of new analgesics has been a complex and difficult task. However, remarkable progress in the identification of novel molecular targets relevant for pain medicines has been reported. Here we will focus on the neuropeptide calcitonin generelated peptide (CGRP) and its receptors (CGRP-R) because of their role in ...
BENEMEI, SILVIA, NICOLETTI, PAOLA, J. A. Capone, GEPPETTI, PIERANGELO   +3 more
openaire   +3 more sources

RAMPs and CGRP Receptors

2012
Receptor activity modifying protein 1 (RAMP1) forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). RAMP1 has two main roles. It facilitates the cell-surface expression of CLR. It is also essential for the binding of CGRP to the receptor.
James, Barwell, Denise, Wootten, John, Simms, Debbie L, Hay, David R, Poyner   +4 more
openaire   +2 more sources

Desensitisation of adrenomedullin and CGRP receptors

Regulatory Peptides, 2003
Adrenomedullin (AM), a potent vasoactive peptide, is elevated in certain disease states such as sepsis. Its role as a physiologically relevant peptide has been confirmed with the advent of the homozygous lethal AM peptide knockout mouse. So far, there have been few and conflicting studies which examine the regulatory role of AM at the receptor level ...
Debbie L, Hay, David R, Poyner, David M, Smith   +2 more
openaire   +2 more sources

Characterization of CGRP Receptor Binding

Current Protocols in Pharmacology, 2004
AbstractCGRP receptor binding may be measured using homogenates of cell membranes or intact cells. Here a microcentrifugation‐based assay is described that utilizes radioiodinated CGRP in displacement studies to determine the binding parameters for any ligand that interacts with CGRP receptors. A similar assay is described for binding to cultured cells.
Alex C, Conner, Debbie L, Hay, David R, Poyner   +2 more
openaire   +2 more sources

The Pharmacology of Adrenomedullin Receptors and Their Relationship to CGRP Receptors

Journal of Molecular Neuroscience, 2004
Adrenomedullin (AM) has two specific receptors formed by the calcitonin-receptor-like receptor (CL) and receptor activity-modifying protein (RAMP) 2 or 3. These are known as AM1 and AM2 receptors, respectively. In addition, AM has appreciable affinity for the CGRP1 receptor, composed of CL and RAMP1.
Debbie L, Hay, Alex C, Conner, Stephen G, Howitt, David M, Smith, David R, Poyner   +4 more
openaire   +2 more sources

CGRP Receptors

Headache Currents, 2004
Neuronal Expression and Regulation of CGRP Promoter Activity Following Viral Gene Transfer into Cultured Trigeminal Ganglia Neurons We examined the regulation of calcitonin gene‐related peptide (CGRP) promoter activity in primary cultures of rat trigeminal ganglia neurons.
openaire   +1 more source

The Structure of the CGRP and Related Receptors

2018
The canonical CGRP receptor is a complex between calcitonin receptor-like receptor (CLR), a family B G-protein-coupled receptor (GPCR) and receptor activity-modifying protein 1 (RAMP1). A third protein, receptor component protein (RCP) is needed for coupling to Gs.
John, Simms, Sarah, Routledge, Romez, Uddin, David, Poyner   +3 more
openaire   +2 more sources