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The influence of affinity, efficacy, and slope factor on the estimates obtained by the receptorial responsiveness method (RRM): a computer simulation study

open access: yesCanadian Journal of Physiology and Pharmacology, 2010
The receptorial responsiveness method (RRM) was proposed to characterize changes in the concentration of degradable agonists in the microenvironment of their receptors. The characterization is done by providing concentrations of a stable agonist for the same receptor that is equieffective with the change in concentration to be characterized.
Maria, Grenczer   +7 more
exaly   +5 more sources

Effect of asymmetry of concentration–response curves on the results obtained by the receptorial responsiveness method (RRM): an in silico study

open access: yesCanadian Journal of Physiology and Pharmacology, 2010
The receptorial responsiveness method (RRM) was proposed to estimate changes in the concentration of an agonist in the microenvironment of its receptor. Usually, this is done by providing the equieffective concentration of another agonist for the same receptor or for a largely overlapping postreceptorial signaling (“test agonist”).
Maria, Grenczer   +7 more
openaire   +3 more sources
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Methods for assessing responsiveness

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Insulin regulation of muscle glucose metabolism: Role of pre-receptorial mechanisms

Diabetes/metabolism Reviews, 1995
Brunella Capaldo, Luigi Sacca, L Sacca
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Responsiveness of observational and self-report methods for assessing disability in mobility in patients with osteoarthritis.

Arthritis and Rheumatism, 2001
Leo D Roorda   +2 more
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