Results 41 to 50 of about 29,601 (261)

Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease [PDF]

Journal of Biomedical Science, 2018
Adiponectin (ADN) is an adipokine derived from adipocytes. It binds to adiponectin receptor 1 and 2 (AdipoR1 and R2) to exert its function in regulating whole-body energy homeostasis and inflammatory responses. However, the role of ADN-AdipoR1 signaling in intestinal inflammation is controversial, and its role in the regulation of neutrophils is still ...
Yu-Ju Peng, Tang-Long Shen, Yu-Shan Chen, Harry John Mersmann, Bing-Hsien Liu, Shih-Torng Ding   +5 more
openaire   +3 more sources

Roles of Adiponectin Signaling Related Proteins in Mammary Tumor Development

Southern Clinics of Istanbul Eurasia, 2019
INTRODUCTION[|]This study aims to investigate the expression levels of adiponectin signaling related proteins in mammary tissue, liver and breast cancer tissue in mice.
Bilge Güvenç Tuna, Margot Cleary, Soner Doğan   +2 more
doaj   +1 more source

CORRELATION OF LEPTIN AND ADIPONECTIN RECEPTOR EXPRESSION WITH CLINICOPATHOLOGICAL PARAMETERS IN COLORECTAL CARCINOMA - A CROSS-SECTIONAL PROSPECTIVE STUDY [PDF]

Arquivos de Gastroenterologia
Background: Colorectal carcinoma (CRC) is one of the common carcinomas with a rising incidence of metastasis due to its advanced stage of presentation.
Priyanka PARMESH, Udupi Shastri DINESH, Ajay S KHANDAGALE, Anil Bargale BAPU, Roshni SADASHIV, Pradnya REDDY   +5 more
doaj   +1 more source

An Explanation for the Adiponectin Paradox

Pharmaceuticals, 2021
The adipokine adiponectin improves insulin sensitivity. Functional signal transduction of adiponectin requires at least one of the receptors AdipoR1 or AdipoR2, but additionally the glycosyl phosphatidylinositol-anchored molecule, T-cadherin ...
Hans O. Kalkman
doaj   +1 more source

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons

Molecular Metabolism, 2016
Objective: Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation – including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons.
Jia Sun, Yong Gao, Ting Yao, Yiru Huang, Zhenyan He, Xingxing Kong, Kai-jiang Yu, Rui-tao Wang, Hongbo Guo, Jianqun Yan, Yongsheng Chang, Hong Chen, Philipp E. Scherer, Tiemin Liu, Kevin W. Williams   +14 more
doaj   +1 more source

Adiponectin and its receptors in the ovary: further evidence for a link between obesity and hyperandrogenism in polycystic ovary syndrome. [PDF]

PLoS ONE, 2013
Polycystic ovary syndrome (PCOS), characterized by ovarian androgen excess, is the commonest endocrine disorder in women. Obesity increases androgen synthesis, a phenomenon attributed to the accompanying hyperinsulinemia.
Fabio V Comim, Kate Hardy, Stephen Franks   +2 more
doaj   +1 more source

Single nucleotide polymorphisms in adiponectin and its receptors’ genes as potential risk factors for coronary artery disease in type 2 diabetes mellitus – an up-to-date overview

Journal of Education, Health and Sport, 2021
Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with still growing incidence among adults and young people worldwide.
Joanna Szydełko, Izabela Dąbrowska
doaj   +1 more source

Variants of the Adiponectin and Adiponectin Receptor 1 Genes and Breast Cancer Risk [PDF]

Cancer Research, 2008
Abstract Breast cancer risk is higher among obese women and women with diabetes. Adiponectin is a protein exclusively secreted by adipose tissue, circulating levels of which have been associated with breast cancer risk. Whether genetic variants within the adiponectin pathway are associated with breast cancer risk is unknown.
Virginia G, Kaklamani, Maureen, Sadim, Alex, Hsi, Kenneth, Offit, Carole, Oddoux, Harry, Ostrer, Habibul, Ahsan, Boris, Pasche, Christos, Mantzoros   +8 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Regulation of lung inflammation by adiponectin

Frontiers in Immunology, 2023
Adiponectin is an insulin sensitizing hormone that also plays a role in the regulation of inflammation. Although adiponectin can exert pro-inflammatory effects, more studies have reported anti-inflammatory effects, even in non-adipose tissues such as the
Joo-Yeon Lim, Steven P. Templeton
doaj   +1 more source