Results 21 to 30 of about 29,601 (261)

Adiponectin/adiponectin receptor in disease and aging

npj Aging and Mechanisms of Disease, 2015
AbstractAdipocytes are not merely organs for energy conservation but endocrine organs secreting a wide array of physiologically active substances, i.e., adipokines. Of these adipokines, adiponectin is known to exert anti-diabetic and anti-atherosclerotic effects via adiponectin receptors (AdipoR)s, AdipoR1 and AdipoR2.
Iwabu, Masato, Okada-Iwabu, Miki, Yamauchi, Toshimasa, Kadowaki, Takashi   +3 more
openaire   +2 more sources

Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages [PDF]

Atherosclerosis, 2013
Adiponectin is one of several important, metabolically active cytokines secreted from adipose tissue. Epidemiologic studies have associated low circulating levels of this adipokine with multiple metabolic disorders including obesity, insulin resistance, type II diabetes, and cardiovascular disease.
Nanlan, Luo, B Hong, Chung, Xiangdong, Wang, Richard L, Klein, Chao-Ke, Tang, W Timothy, Garvey, Yuchang, Fu   +6 more
openaire   +2 more sources

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Adiponectin-Mediated Analgesia and Anti-Inflammatory Effects in Rat. [PDF]

PLoS ONE, 2015
The adipose tissue-derived protein, adiponectin, has significant anti-inflammatory properties in a variety of disease conditions. Recent evidence that adiponectin and its receptors (AdipoR1 and AdipoR2) are expressed in central nervous system, suggests ...
Tommaso Iannitti, Annette Graham, Sharron Dolan   +2 more
doaj   +1 more source

Effects of interventions on adiponectin and adiponectin receptors

Journal of Exercise Rehabilitation, 2014
Adiponectin secreted from adipose tissue binds to two distinct adiponectin receptors (AdipoR1 and AdipoR2) identified and exerts its anti-diabetic effects in insulin-sensitive organs including liver, skeletal muscle and adipose tissue as well as amelioration of vascular dysfunction in the various vasculatures.
Lee, Sewon, Kwak, Hyo-Bum
openaire   +2 more sources

Insulin regulates the expression of adiponectin and adiponectin receptors in porcine adipocytes [PDF]

Domestic Animal Endocrinology, 2008
Adiponectin is an adipocyte-derived hormone that can improve insulin sensitivity. Its functions in regulating glucose utilization and fatty acid metabolism in mammals are mediated by two subtypes of adiponectin receptors (AdipoR1 and AdipoR2). This study was conducted to determine the effect of insulin on the expression of adiponectin and its receptors.
Liu, Bing Hsien, Wang, Ya Chin, Wu, Shinn Chih, Mersmann, Harry John, Cheng, Winston Teng Kuei, Ding, Shih Torng   +5 more
openaire   +3 more sources

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Role of Perivascular Adipose Tissue-Derived Adiponectin in Vascular Homeostasis

Cells, 2021
Studies of adipose tissue biology have demonstrated that adipose tissue should be considered as both passive, energy-storing tissue and an endocrine organ because of the secretion of adipose-specific factors, called adipokines.
Adrian Sowka, Pawel Dobrzyn
doaj   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Crystal structures of the human adiponectin receptors [PDF]

Nature, 2015
Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules.
Tanabe, Hiroaki, Fujii, Yoshifumi, Okada-Iwabu, Miki, Iwabu, Masato, Nakamura, Yoshihiro, Hosaka, Toshiaki, Motoyama, Kanna, Ikeda, Mariko, Wakiyama, Motoaki, Terada, Takaho, Ohsawa, Noboru, Hato, Masakatsu, Ogasawara, Satoshi, Hino, Tomoya, Murata, Takeshi, Iwata, So, Hirata, Kunio, Kawano, Yoshiaki, Yamamoto, Masaki, Kimura-Someya, Tomomi, Shirouzu, Mikako, Yamauchi, Toshimasa, Kadowaki, Takashi, Yokoyama, Shigeyuki   +23 more
openaire   +2 more sources