Results 231 to 240 of about 141,931 (309)

Occupancy of alpha 1-adrenergic receptors and contraction of rat vas deferens.

Molecular Pharmacology, 1983
The interaction of agonists and antagonists with alpha 1-adrenergic receptors in rat vas deferens was examined using radioligand binding assays and contractility measurements.
K. Minneman, A. Fox, Peter W. Abel
semanticscholar   +1 more source

Transcriptional regulation of alpha-1 adrenergic receptors

Frontiers in Bioscience, 1998
Regulation of alpha1-adrenergic receptors (alpha1ARs) is a rapidly expanding field of study due to the involvement of these receptors in several human diseases. For example, upregulation of alpha1bAR mRNA/protein with agonist exposure has been implicated in myocardial hypertrophy.
D R, Scanga, D A, Schwinn
openaire   +2 more sources

Characterization of alpha-adrenergic receptor subtypes in the rat renal cortex. Differential regulation of alpha 1- and alpha 2-adrenergic receptors by guanyl nucleotides and Na.

Molecular Pharmacology, 1982
We have used the subtype-selective radioligands [3H]prazosin (an alpha 1-adrenergic antagonist) and [3H]yohimbine (an alpha 2-adrenergic antagonist) to examine alpha-adrenergic receptors in rat renal cortical membranes.
Snavely, Insel Pa
semanticscholar   +1 more source

Renal alpha-1 and alpha-2 adrenergic receptors: biochemical and pharmacological correlations.

Journal of Pharmacology and Experimental Therapeutics, 1981
[3H]Dihydroergocryptine, a nonselective alpha adrenergic antagonist, the alpha-1 selective antagonist, [3H]prazosin and the alpha-2 selective antagonist, [3H]yohimbine, were used to study binding sites in rat renal membranes.
J. M. Schmitz, Robert M. Graham, A. Sagalowsky, William A. Pettinger   +3 more
semanticscholar   +1 more source

The hepatic alpha1-adrenergic receptor

Biochemical Pharmacology, 1984
Since the relatively recent advent of radioligand binding techniques, it has been possible to directly identify and characterize hepatic adrenergic receptors as well as study their physiological regulation. While it is now clear that alpha 1-adrenergic receptors constitute the major population of hepatic adrenergic receptors and are primarily ...
M, Goodhardt, N, Ferry, M, Aggerbeck, J, Hanoune   +3 more
openaire   +2 more sources

Alpha 1-adrenergic receptor structure.

Molecular Pharmacology, 1984
The structure of the alpha 1-adrenergic receptor was investigated by comparing polypeptides identified by sodium dodecyl sulfate (NaDodSO4)-polyacrylamide gel electrophoresis with the size of the intact receptor in cell membranes as determined by target size analysis.
J C, Venter, P, Horne, B, Eddy, R, Greguski, C M, Fraser   +4 more
openaire   +2 more sources

Differentiation of alpha 1-adrenergic receptors linked to phosphatidylinositol turnover and cyclic AMP accumulation in rat brain.

Molecular Pharmacology, 1987
Activation of alpha 1-adrenergic receptors in slices of rat brain increases inositol phosphate accumulation, increases basal cyclic AMP accumulation, and potentiates the increase in cyclic AMP caused by adenosine.
R. D. Johnson, K. Minneman
semanticscholar   +1 more source

Alpha-1 adrenergic receptors in the nonfailing and failing human heart.

Journal of Pharmacology and Experimental Therapeutics, 1988
We examined alpha-1 adrenergic receptor density in ventricular myocardium from nonfailing and failing human hearts, utilizing the alpha-1 radioligand [125I]IBE2254.
M. Bristow, W. Minobe, R. Rasmussen, R. Hershberger, B. Hoffman   +4 more
semanticscholar   +1 more source

Heterogeneity of alpha-1 Adrenergic Receptors

1987
The alpha-1 adrenergic receptor, located postjunctionally on smooth muscle and other tissues, has been studied for decades, although not recognized as a specific subtype. Until recently, alpha-adrenergic receptors were not subdivided, and the alpha-adrenergic receptor-mediated responses commonly measured, such as contraction of smooth muscle in vitro ...
J. Paul Hieble, William D. Matthews, Robert M. DeMarinis, R. Robert Ruffolo   +3 more
openaire   +1 more source

"Spare" alpha 1-adrenergic receptors and the potency of agonists in rat vas deferens.

Molecular Pharmacology, 1984
The existence of "spare" alpha 1-adrenergic receptors in rat vas deferens was examined directly using radioligand binding assays and contractility measurements.
K. Minneman, Peter W. Abel
semanticscholar   +1 more source