Results 251 to 260 of about 141,931 (309)
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Journal of Pharmacology and Experimental Therapeutics, 1995
We have cloned cDNAs encoding three human alpha-1 adrenergic receptor (AR) subtypes and characterized pharmacological properties of the expressed receptor protein.
D. Schwinn +9 more
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We have cloned cDNAs encoding three human alpha-1 adrenergic receptor (AR) subtypes and characterized pharmacological properties of the expressed receptor protein.
D. Schwinn +9 more
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Effects of Selective Alpha-1-Adrenergic Receptor Blockers on Bladder Weight
Urologia Internationalis, 2006<i>Introduction:</i> This study was undertaken to investigate the effects of two different α<sub>1</sub>-adrenergic blockers on bladder hypertrophy using ultrasound-estimated bladder weight (UEBW) and to assess the relation between changes in UEBW and other objective and subjective parameters of disease severity in patients with
Tulga, Egilmez +5 more
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Biochemistry and Pharmacology of the alpha-1 Adrenergic Receptor
1987The biochemical and pharmacological characterization of the alpha-1 adrenergic receptor binding site has been dependent upon two advances, one conceptual and the other technical. The conceptual development was the subclassification of alpha-adrenergic receptors into alpha-1 and alpha-2 receptors, as detailed in the first chapter of this book.
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Vascular alpha-1 adrenergic receptor subtypes in the regulation of arterial pressure
Life Sciences, 1995Alpha 1 (alpha 1)-adrenoceptors can be found at numerous end organs in the autonomic nervous system, especially vascular smooth muscle. The tonic sympathetic activation of vascular alpha 1-adrenoceptors maintains vascular resistance and is vital to the regulation of arterial pressure.
H M, Vargas, A J, Gorman
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Alpha 1-adrenergic receptor stimulated responses.
Journal of cardiovascular pharmacology, 1988alpha 1 Receptors have been investigated using a variety of experimental approaches. alpha 1-Receptor stimulation of phosphoinositide (PI) hydrolysis shows differences in agonist efficacy. The potency series and antagonists clearly suggest that alpha 1 receptors are coupled to phosphoinositide hydrolysis.
F T, Crews +4 more
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Alpha(1)-Adrenergic Receptors in the Adult, Neonatal, and Fetal Canine Heart
Developmental Pharmacology and Therapeutics, 2017Using the radioligand, iodo-2-[beta-(4-hydroxphenyl)ethylaminomethyl] tetralone ([l^251]-IBE 2254), alphai-adrenergic receptors were identified in membranes isolated from fetal, neonatal, and adult canine ventricular myocardium. Binding of the radioligand to alpha(1)-adrenergic sites in adult canine heart was rapid, reversible, stereoselective and ...
S D, Buchthal +2 more
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Autoradiographic delineation of skeletal muscle alpha 1-adrenergic receptor distribution
American Journal of Physiology-Heart and Circulatory Physiology, 1990We used light microscopic autoradiography to quantify the distribution of alpha 1-adrenergic receptors in vessels and muscle fibers of slow-twitch (type I), fast-twitch (types IIa and IIb), and mixed fiber muscles of the rat hindquarter. Frozen cross sections of soleus, vastus lateralis, and gastrocnemius muscles were incubated under equilibrium ...
W H, Martin, T K, Tolley, J E, Saffitz
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Stimulation of alpha-1 adrenergic receptors facilitates spatial learning in rats
European Neuropsychopharmacology, 1998The present experiments were designed to examine the effects of alpha-1 adrenergic stimulation and inhibition on memory encoding and to investigate whether the alpha-1 adrenergic and muscarinic cholinergic systems interact in the regulation of spatial navigation behavior in the Morris water maze test and we also studied the effects of D-cycloserine, a ...
T, Puumala +5 more
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Ontogeny of mammalian cardiac α1-adrenergic receptors
European Journal of Pharmacology, 1980We find a similar number of alpha 1-adrenergic receptors in fetal mouse hearts of 15--20 day gestational age as compared to adult mouse hearts, and a significantly greater number of alpha 1-adrenoceptors in the early neonate (7--21 days) hearts. Cardiac norepinephrine (NE) concentrations were extremely low in the fetus and increased continuously after ...
S, Yamada, H I, Yamamura, W R, Roeske
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