Results 141 to 150 of about 93,900,112 (260)

Association of G-Protein-Coupled Receptors autoantibodies with vasoregulation in Post-COVID.

PLoS ONE
BackgroundThe Post-COVID syndrome is associated with the generation of autoantibodies to vasoregulative G-protein coupled receptors (GPCR). It remains elusive, however, whether these autoantibodies play a pathophysiological role in this disease.
Felix S Seibert, Melisa Kurucay, Lea Wiemers, Ulrik Stervbo, Oliver Sander, Monika Segelbacher, Maximilian Seidel, Sebastian Bertram, Nina Babel, Timm H Westhoff   +9 more
doaj   +1 more source

Sleep‐Autonomic Interactions in Parkinson's Disease and Multiple System Atrophy: A Comparative Study Using Structural Equation Modeling

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) and multiple system atrophy (MSA) are α‐synucleinopathies with overlapping autonomic and sleep dysfunction, but distinct trajectories. Objectives This study compared sleep and autonomic profiles in PD and MSA and elucidated disease‐specific associations using structural equation modeling (SEM).
Bora Jin, Yoonkyung Lee, Seungho Lee, Byeol‐A Yoon, Young Jin Jeong, Sang‐Myung Cheon   +5 more
wiley   +1 more source

The Benefits of Adding Non‐Antimuscarinic Pharmaceuticals in Combination With Beta‐3 Agonists for Overactive Bladder Treatment: A Systematic Review

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction Antimuscarinics, as the current first‐line pharmacologic therapies for overactive bladder, exhibit low patient adherence and high rates of reported side effects. As a modern alternative pharmaceutical treatment, beta‐3 agonists, which relax the urinary bladder, may be more tolerable for patients, increasing adherence and ...
Felicity Smith, Charlotte Phelps, Christian Moro   +2 more
wiley   +1 more source

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.

, 1989
Homologous (agonist-specific) desensitization of beta-adrenergic receptors (beta ARs) is accompanied by and appears to require phosphorylation of the receptors.
Lohse, MJ, Lefkowitz, RJ, Caron, MG, Benovic, JL   +3 more
core   +1 more source

Activation of beta(2)-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure

, 1999
Background-Catecholamines hasten cardiac relaxation through beta-adrenergic receptors, presumably by phosphorylation of several proteins, but it is unknown which receptor subtypes are involved in human ventricle. We assessed the role of beta(1)- and beta(
Vetter, D., Bartel, S., Molenaar, P., Krause, E.G., Burrell, K., Sanders, L., Bartel, S, Vetter, D, Hempel, P, Karczewski, P., Krause, EG, Molenaar, P, Karczewski, P, Kaumann, A, Sanders, L, Hempel, P., Burrell, K, Kaumann, A.   +17 more
core  

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

The human heart beta-adrenergic receptors. I. Heterogeneity of the binding sites: presence of 50% beta 1- and 50% beta 2-adrenergic receptors.

, 1983
Beta-adrenergic receptors were characterized in a particulate fraction of human auricles obtained from patients operated upon for coronary insufficiency or valvular disease.
De Smet, Jean-Marie, Delhaye, Myriam, De Neef, Philippe, Christophe, Jean, Waelbroeck, Magali, Chatelain, Pierre, Taton, Gérard, Leclerc, Jean Louis, Robberecht, Patrick   +8 more
core  

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Integrative Approaches in Cardiovascular Disease: The Role of Nutraceuticals in Heart Failure, Atrial Fibrillation, and Related Conditions

Phytotherapy Research, EarlyView.
Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli, Ivan Corazza, Roberta Budriesi, Luca Camarda, Maria Carelli, Alberto Spadotto, Igor Diemberger   +6 more
wiley   +1 more source

Pharmaceuticals in the aquatic environment: β-blockers as a case study [PDF]

, 2008
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 20/09/2008.The presence of many human pharmaceuticals in the aquatic environment is now a worldwide concern and yet little is known of the chronic effects ...
Giltrow, Emma
core   +1 more source