Results 91 to 100 of about 86,830 (247)

Efficacy and Safety of Lisdexamfetamine Versus Topiramate Versus Naltrexone/Bupropion in Individuals With Binge Eating Disorder: A Network Meta‐Analysis

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of lisdexamfetamine, topiramate, and naltrexone/bupropion for treating binge eating disorder (BED) using network meta‐analysis. Method We systematically searched PubMed, Scopus, ClinicalTrials.gov, and Cochrane Central up to February 2025 for randomized controlled trials evaluating these medications
Tamer Hodrob, Ibrahim Ismail, Alaaeddin Abusalameh, Celina R. Andonie, Omar Ayesh, Hazem Ayesh   +5 more
wiley   +1 more source

Mechanisms of Action Involved in the In Vivo Gastroprotective Response of Fruits: A Systematic Review

Food Frontiers, EarlyView.
ABSTRACT Gastrointestinal diseases remain a significant global health concern, primarily due to the limitations of current pharmacological treatments, which often come with adverse side effects and high recurrence rates. This situation highlights the urgent need for safer and more effective alternatives.
Isabel Sousa Alcântara, Renata Torres Pessoa, Lucas Yure Santos da Silva, Tarcisio Mendes Silva, Isis Oliveira Menezes, Anita Oliveira Brito Pereira Bezerra Martins, Irwin Rose Alencar de Menezes, Almir Gonçalves Wanderley   +7 more
wiley   +1 more source

Integrative Evidence From Metabolome‐Wide Mendelian Randomization and Animal Models Implicates Tyrosine in Cardiac Hypercontractility and Arrhythmia Risk

Food Frontiers, EarlyView.
Plasma metabolome‐wide Mendelian randomization analysis established a causal link between tyrosine and arrhythmia. GWAS meta‐analysis identified tyrosine‐associated loci linked to cardiovascular risk factors. Animal studies confirmed that oral tyrosine intake modulates heart rhythm via adrenergic signaling activation.
Zhikang Cao, Huiying Liu, Peng Chen, Liyue Chen, Zhixin Chen, Jiaqiang Lin, Zixuan Fu, Zhipeng Li   +7 more
wiley   +1 more source

Recurrent Priapism After Living Donor Kidney Transplantation Requiring Bilateral T‐Shunt Procedure: A Case Report

IJU Case Reports, EarlyView.
ABSTRACT Introduction Priapism is a persistent penile erection lasting > 4 h without sexual stimulation. Ischemic priapism requires urgent management. We report a recurrent ischemic priapism case post‐living‐donor kidney transplantation necessitating multiple interventions, including bilateral T‐shunt procedures.
Hiroto Kishino, Toru Sugihara, Takuya Iwaki, Sho Nishida, Kyoko Minamisono, Takehiro Oyama, Satoshi Ando, Kimihiko Moriya, Daiki Iwami, Tetsuya Fujimura   +9 more
wiley   +1 more source

Intranasal Naloxone During Recurrent Exercise in Individuals with Type‐1 Diabetes Mellitus: Evaluation of the Clinical Predictors of Pharmacokinetics and Exposure–Response

The Journal of Clinical Pharmacology, EarlyView.
Abstract Impaired awareness of hypoglycemia (IAH) impacts 25%–30% of individuals with type 1 diabetes mellitus (T1D), potentially leading to severe outcomes due to reduced symptom perception. Naloxone, a mu‐opioid receptor antagonist, shows promise as a preventive measure against IAH.
Omar N. Al Yacoub, Shen Cheng, Mohamed S. Fayed, James Fisher, Jillian Brooks, Elizabeth Seaquist, Anjali Kumar, Amir Moheet, Lynn Eberly, Lisa D. Coles   +9 more
wiley   +1 more source

A Simple and Scalable Synthesis of N‐Nitroso Salbutamol Impurities A, D, and F

Journal of Heterocyclic Chemistry, EarlyView.
ABSTRACT To ensure strict quality control standards, improve yields, and meet regulatory requirements, the synthesis of N‐nitroso impurities of salbutamol is essential. These studies help in understanding, monitoring, and mitigating the risks associated with the presence of potentially harmful nitrosamine impurities in pharmaceuticals.
Kottolla Sai Prasad, Chithaluri Sudhakar, Vijaya Krishna Ravi   +2 more
wiley   +1 more source

The Efficacy and Safety of Atenolol for Treatment of Infantile Hemangioma

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Infantile hemangiomas are the most common benign vascular tumours in children. Since the discovery of propranolol for infantile hemangiomas, its increasing side effect profile has prompted research into its beta‐1‐selective counterpart, atenolol.
Michelle Shi, Artiene Tatian, Susan Adams, Orli Wargon   +3 more
wiley   +1 more source

Effectiveness and Safety of Dupilumab Monotherapy in Japanese Patients With Chronic Rhinosinusitis With Nasal Polyps

The Laryngoscope, EarlyView.
In this phase 4, open‐label, single‐arm, multicenter study, dupilumab monotherapy was associated with reductions from baseline to week 24 (primary endpoint) in the bilateral endoscopic Nasal Polyp Score (NPS) in 25 Japanese adults with inadequately controlled chronic rhinosinusitis with nasal polyps on standard care therapies.
Shigeharu Fujieda, Tetsuji Takabayashi, Nobuo Ohta, Mamoru Yoshikawa, Yuki Kibe, Masato Ishida, Katsuhisa Suzuki, Yoshinori Takahashi, Nikhil Amin, Lakiea Wright, Lacey Robinson, Kenji Yahata   +11 more
wiley   +1 more source

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Medicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang   +3 more
wiley   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, EarlyView.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source