Results 221 to 230 of about 168,706 (292)

Posttranslational modifications of phosphodiesterase type 4 enzymes represent novel points for therapeutic targeting

The FEBS Journal, EarlyView.
Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain, Gonzalo S. Tejeda, George S. Baillie   +2 more
wiley   +1 more source

Adrenergic signals influence proteomic responses in breast cancer cells. [PDF]

Front Neurosci
Carrasco M, Bjørnstad OV, Vethe H, Akslen LA.   +3 more
europepmc   +1 more source

Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35

The FEBS Journal, EarlyView.
Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima, Sayako Shimomura, Mayuka Wakabayashi, Wei Qi Loh, Harumi Ando, Haruka Sei, Hiroyuki Hattori, Didik Huswo Utomo, Masaki Kita, Asuka Inoue, Koji Uchida, Takahiro Shibata   +11 more
wiley   +1 more source

Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm. [PDF]

Inflammopharmacology
Ghosn A, Bassam K, Al Zein M, Nasser SA, Pintus G, Eid AH.   +5 more
europepmc   +1 more source

Global Patterns of Comorbidities Among Patients With Hidradenitis Suppurativa: A Systematic Review and Meta‐Analysis

International Journal of Dermatology, EarlyView.
ABSTRACT Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder increasingly recognized as a systemic disease with diverse comorbidities. While several comorbid conditions are well documented, regional differences in prevalence remain unclear.
Aditya K. Gupta, Amanda Liddy, Vasiliki Economopoulos, Renata Magalhaes   +3 more
wiley   +1 more source

Metabolic override: Adding neuropeptide Y to the list of vasoconstrictors attenuated by exercise. [PDF]

J Physiol
Bommarito JC, Millar PJ.
europepmc   +1 more source

You Can’t Hold Their Hand the Whole Time: A Qualitative Study of Parents’ Experiences of Adolescents With Food Allergy

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To explore parents’ experiences of parenting adolescents with food allergies. Design An interpretive descriptive qualitative study. Methods Semi‐structured interviews were conducted between November 2023 and March 2024 with 11 parents of adolescents with food allergies aged 12–16 years, 8 mothers and 3 fathers. Reflexive thematic analysis
Meg O’ Sullivan, Rachel Flynn, James O’ Mahony, Juan Trujillo, Margaret Curtin   +4 more
wiley   +1 more source

In Silico Multitarget Profiling of Non-Selective Beta-Blockers Highlights Their Potential as Key Agents in Breast Cancer Adjuvant Therapy via ADRB2, ERBB2, and NPYR Receptors. [PDF]

Curr Issues Mol Biol
Muñoz-González F, Correa-Basurto J, Ignacio-Mejia I, Bandala C.   +3 more
europepmc   +1 more source

The exposomal imprint on rosacea: More than skin deep

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Rosacea reflects systemic and environmental interactions, not just a skin disorder. Key factors include environmental triggers, genetic and microbiome influences, diagnostic gaps in skin of colour and social determinants. Advances in multi‐omics and exposome integration highlight pathways towards precision medicine, prevention and equitable, patient ...
Katerina Grafanaki, Daniella Bakoli Sgourou, Alexandros Maniatis, Efstathia Pasmatzi   +3 more
wiley   +1 more source