Results 71 to 80 of about 86,830 (247)

Comparative Study of the Effects of Drugs Targeting Adrenergic Receptors on the Early Life Stages of Zebrafish

Toxics
Owing to the presence of drugs targeting adrenergic receptors in aquatic ecosystems, considerable attention has been directed towards their environmental distribution and fate in recent decades.
Junsheng Lv, Fengzhu Sun, Zaitian Li, Yueyun Qin, Ruozhu Sheng, Liwei Sun   +5 more
doaj   +1 more source

Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic and Serotonergic Receptors

Journal of Pharmacological Sciences, 2009
We investigated the effects of Evodiae Fructus and synephrine, one of the components of Evodiae Fructus, on blood vessels. We found that Evodiae Fructus (1 × 10−4 g/mL) had constrictive effects on rat aorta.
Tomoko Hibino, Mitsutoshi Yuzurihara, Yoshio Kase, Atsushi Takeda   +3 more
doaj   +1 more source

Endothelium‐Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca2+ Channels

Chemistry &Biodiversity, EarlyView.
Involvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Martina Odebrecht Cavichiolo, Rita de Cássia Vilhena da Silva, Valdir Cechinel Filho, Priscila de Souza   +3 more
wiley   +1 more source

Beta-Adrenergic Receptors and Mechanisms in Asthma: The New Long-Acting Beta-Agonists

Allergology International, 1996
The objective is to review β-adrenergic receptors and mechanisms in the immediate and late bronchial reaction in asthma and the new long-acting β-agonist.
Robert G Townley
doaj   +1 more source

Procedural Characteristics and Safety of Slender Percutaneous Coronary Intervention: Slender Is Better

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Objectives We aimed to examine the procedural characteristics and safety profile of slender percutaneous coronary interventions (PCI) using a 5 Fr or smaller sheath. Background Smaller catheter size has been associated with fewer complications in PCI.
Fuminobu Yoshimachi, Kyohei Yamaji, Shun Kohsaka, Yota Kawamura, Satoshi Kasai, Toshiharu Fujii, Hirofumi Nagamatsu, Kazushige Amano, Yuka Karasawa, Shinichiro Yamada, Yoshihisa Nakagawa, Yuji Ikari   +11 more
wiley   +1 more source

Study of nerve fibers nature reinforcing duodenal contractions by electrical stimulation of sympathetic nerve [PDF]

Саратовский научно-медицинский журнал, 2011
The subject of the article is to investigate the mechanism of increased reactions by electrical stimulation of the sympathetic nerve. Materials and methods: Experiments on dogs have shown that stimulant reactions during blockade of a-adrenergic by ...
Sveshnikov D.S., Kirichuk V.F., Smirnov V.M., Myasnikov I. L, Kuchuk A.M., Trofimova J.E., Trubetskaya M.A.   +6 more
doaj  

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source