Results 171 to 180 of about 106,627 (314)

Evaluation of Polar Substituted Schiff Bases and 1,2,3‐Triazole Hybrids as Anticancer Agents

Chemistry &Biodiversity, EarlyView.
ABSTRACT Polar substituted Schiff bases and 1,2,3‐triazole hybrids (2–6) were successfully synthesized by Schiff base condensation reaction between the previously synthesized triazole 1 and series of polar substituted amines. The chemical structures of the hybrids were confirmed using spectroscopies (NMR and FTIR), CHN elemental analysis and single ...
Yonas Belay, Alfred Muller, Sage Singh, Adedapo S. Adeyinka, Lesetja R. Motadi, Abel K. Oyebamiji   +5 more
wiley   +1 more source

Estudio de la expresión de receptores de andrógenos, estrógenos y progesterona mediante inmunohistoquímica en pacientes con alopecia frontal fibrosante

Revista Médica Clínica Las Condes, 2023
Resumen: Introducción: La alopecia frontal fibrosante (AFF) es una alopecia linfocítica primaria cicatricial, cuya patogenia se desconoce. Se han desarrollado distintos regímenes de tratamientos farmacológicos, siendo el finasteride por sí sólo o en ...
Néstor Carreño-Orellana, Daniela Alfaro-Sepúlveda, María Paz Traipe, Verónica Vial-Letelier   +3 more
doaj  

Chemical sensing by cell-surface chemoreceptor arrays: the roles of receptor cooperativity and adaptation [PDF]

arXiv, 2012
Most sensory cells use cross-membrane chemoreceptors to detect chemical signals in the environment. The biochemical properties and spatial organization of chemoreceptors play important roles in achieving and maintaining sensitivity and accuracy of chemical sensing.
arxiv  

Solvent‐free Process for Preparing Metal‐organic Framework Composites based on Carbon‐based Quantum Dots and their Derivatives as Drug Delivery Systems for Andrographolide

Chemistry – A European Journal, Accepted Article.
Andrographolide (ADG) was conjugated with MIL‐53(Al), ZIF‐8, carbon‐based quantum dots (CBQDs) and doped carbon‐based quantum dots (D‐CBQDs) using high‐pressure (0.3 GPa) contact. This solvent‐free approach is environmentally friendly, energy‐efficient and time‐saving, resulting in ADG‐MOFs‐CBQDs/D‐CBQDs with physical properties comparable to those ...
Wenndy Pantoja-Romero, Alexis Lavín-Flores, Gerardo Morell, Magaly Martínez, Brad R. Weiner, Joaquin Coronas   +5 more
wiley   +1 more source

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost, Jeremy Y. Huang, Georgia Dermentzaki, Anna S. Blazier, Giorgio Gaglia, Timothy R. Hammond, Francesca Frau, Mary Clare McCorry, Dimitry Ofengeim, Jennifer L. Wilson   +9 more
wiley   +1 more source

Spicy Food and Chili Peppers and Multiple Health Outcomes: Umbrella Review

Molecular Nutrition &Food Research, Volume 66, Issue 23, December 2022., 2022
To assess the quality and strength of the associations between spicy food and chili pepper consumption and different health outcomes. An umbrella review is performed in humans. Direct correlations exist in esophageal cancer, gastric cancer, and gallbladder cancer.
Zhimin Ao, Zongyue Huang, Hong Liu
wiley   +1 more source

Roles of estrogen and its receptors in polycystic ovary syndrome

Frontiers in Cell and Developmental Biology
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by abnormal steroid hormone levels in peripheral blood and poor-quality oocytes.
Yao Xu, Ziyi Zhang, Ziyi Zhang, Rongxiang Wang, Songguo Xue, Qian Ying, Liping Jin, Liping Jin   +7 more
doaj   +1 more source

Changing trends in anabolic‐androgenic steroid use within Scottish prisons: Detection, prevalence, and quantitation

Drug Testing and Analysis, EarlyView.
This study reports the qualitative and quantitative detection of anabolic‐androgenic steroids (AASs) in seized samples from prisons. Since 2022 there has been an increase in AAS detections with oxymetholone the most prevalent AAS, followed by metandienone, methyltestosterone, and oxandrolone.
Caitlyn Norman, Richard L. Harries, Robert Reid, Lorna A. Nisbet, Niamh Nic Daéid   +4 more
wiley   +1 more source

Skeletal Muscle Memory: An Update From the Antidoping Perspective

Drug Testing and Analysis, EarlyView.
ABSTRACT This narrative review explores the concept of muscle memory, focusing on the physiological and biochemical mechanisms underlying information retention in skeletal muscle tissue as it relates to antidoping. The discussion encompasses the role of satellite cells (SCs) in myonuclei recruitment, resulting in increased myonuclear density and ...
Claire Traversa
wiley   +1 more source

Single‐cell RNA‐sequencing of retrieved human oocytes and eggs in clinical practice and for human ovarian cell atlasing

Molecular Reproduction and Development, Volume 89, Issue 12, Page 597-607, December 2022., 2022
Abstract With the advancement of single‐cell separation techniques and high‐throughput sequencing platforms, single‐cell RNA‐sequencing (scRNA‐seq) has emerged as a vital technology for understanding tissue and organ systems at cellular resolution. Through transcriptional analysis, it is possible to characterize unique or rare cell types, interpret ...
Jordan H. Machlin, Ariella Shikanov
wiley   +1 more source