Results 291 to 300 of about 106,627 (314)

Targeting the Androgen Receptor

Urologic Clinics of North America, 2012
Androgen receptor (AR)-mediated signaling is critical to the growth and survival of prostate cancer. Although medical castration and antiandrogen therapy can decrease AR activity and lower PSA, castration resistance eventually develops. Recent work exploring the molecular structure and evolution of AR in response to hormonal therapies has revealed ...
Terence W. Friedlander, Charles J. Ryan
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Androgen Receptor: An Overview

Critical Reviews™ in Eukaryotic Gene Expression, 1995
The action of androgens in regulating development and growth is mediated by androgen receptor (AR). AR is a member of the steroid hormone receptor superfamily, a class of receptors that function through their ability to regulate the transcription of specific genes.
Alan Saltzman, Chihuei Wang, Atsushi Mizokami, Shuyuan Yeh, Win-Jing Young, Chawnshang Chang, Evan T. Keller, Han-Jung Lee   +7 more
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Androgen receptors and their biology

2001
Publisher Summary The androgen receptor plays an important role in development and differentiated function in both health and disease. Advances in molecular biology have significantly impacted our knowledge of the role of this important member of the steroid receptor superfamily throughout the body. The chapter discusses that androgens freely diffuse
Nancy L. Weigel, Marco Marcelli, Dolores J. Lamb   +2 more
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Androgen receptor mutations and androgen insensitivity

Molecular and Cellular Endocrinology, 2002
The androgen receptor (AR) is a high affinity receptor protein encoded on the human X-chromosome that mediates the actions of androgens during development and in the adult. Defects in this receptor protein result in a wide range of abnormalities of male sexual development.
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Androgens and Androgen Receptor in Dermatology

2002
In addition to male sexual development and maturation, androgens also mediate sebum secretion and hair growth. The effect of androgens is mainly through their binding to the androgen receptor (AR) which is a nuclear receptor superfamily member. These androgen-AR complexes then enhance their target genes’ expression by binding to response elements in ...
Uno Hideo, Itami Satoshi, Inui Shigeki, Pan Huei-Ju, Chang Eugene, Takayasu Susumu, Ye Fangfang, Imamura Koji, Kurata Sotaro, Imamura Koji, Seki Toshihiko, Ideta Ritsuro, Aoki Hirohumi, Adachi Kenji, Vera Price, Loretta Collins, Cynthia A. Heinlein, Chang Chawnshang   +17 more
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The Androgen Receptor: An Overview

1994
Publisher Summary This chapter provides an overview of the androgen receptor (AR). AR is a ligand-activated transcriptional regulatory protein that mediates androgen-induced male sexual development and function. The chapter presents a schematic diagram that highlights the major functional domains of human AR.
Elizabeth M. Wilson, Madhabananda Sar, Choi iok Wong, Zhong Xun Zhou   +3 more
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Nuclear receptors and disease: androgen receptor [PDF]

Essays in Biochemistry, 2004
The androgen receptor (AR) protein regulates transcription of certain genes. Usually this depends upon a central DNA-binding domain that permits the binding of androgen–AR complexes to regulatory DNA sequences near or in a target gene. The AR also has a C-terminal ligand-binding domain and an Nterminal transcription modulatory domain.
Jianhui Wu, Mark Trifiro, Mark Trifiro, Lenore K. Beitel, Lenore K. Beitel, Youssef A. Elhaji, Youssef A. Elhaji, Bruce Gottlieb, Bruce Gottlieb   +8 more
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Androgen receptor polymorphism (CAG repeats) and androgenicity

Clinical Endocrinology, 2005
SummaryObjective  Polymorphism of the androgen receptor (AR) has been related to various pathophysiological conditions, such as osteoporosis and infertility. The objectives of this study were to evaluate the frequency of distribution in a normal Italian population and to assess CAG repeats (CAGr) in other conditions, such as hypoandrogenism ...
CANALE D, CAGLIERESI C, MOSCHINI C, LIBERATI CD, MACCHIA, ENRICO, PINCHERA, ALDO, MARTINO, ENIO   +6 more
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Androgen Receptor Dependence

2019
Androgens and the androgen receptor (AR) play crucial roles in the biology of normal and diseased prostate tissue, including prostate cancer (PCa). This dependence is evidenced by the use of androgen depletion therapy (ADT) as the primary treatment for locally advanced, metastatic, or relapsed PCa.
Aashi Chaturvedi, Scott M. Dehm
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[12] Trafficking of the androgen receptor

1999
Publisher Summary The androgen receptor (AR) belongs to the superfamily of nuclear receptors characterized by a common structure and mechanism of action. The AR is an androgen-dependent transcription factor composed of four domains: the amino-terminal transcription activation domain; the DNA-binding domain, which interacts with a specific DNA ...
Jean-Claude Nicolas, Béatrice Térouanne, Charles Sultan, Virginie Georget   +3 more
openaire   +3 more sources