Results 91 to 100 of about 1,004,480 (189)

PROSPECTS FOR ANTI-B-CELL THERAPY IN RHEUMATOLOGY

Научно-практическая ревматология, 2018
Impaired B-cell immunological tolerance plays a central role in the pathogenesis of autoimmune rheumatic diseases and autoimmune diseases of another nature.
E. L. Nasonov
doaj   +1 more source

Future perspectives in target-specific immunotherapies of myasthenia gravis

Therapeutic Advances in Neurological Disorders, 2015
Myasthenia gravis (MG) is an autoimmune disease caused by complement-fixing antibodies against acetylcholine receptors (AChR); antigen-specific CD4+ T cells, regulatory T cells (Tregs) and T helper (Th) 17+ cells are essential in antibody production ...
Marinos C. Dalakas
doaj   +1 more source

Lineage- and stage-specific activity of antigen receptor gene enhancers during lymphocyte development

Frontiers in Epigenetics and Epigenomics
Lymphocyte development culminates with generation of mature B and T cells that express unique antigen receptors on the cell surface. Genes that encode the two chains of B or T cell receptors are generated via DNA recombination and expressed sequentially ...
Fei Ma, Fatima Zohra Braikia, Ranjan Sen
doaj   +1 more source

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. [PDF]

, 2019
How pathogenic cluster of differentiation 4 (CD4) T cells in rheumatoid arthritis (RA) develop remains poorly understood. We used Nur77-a marker of T cell antigen receptor (TCR) signaling-to identify antigen-activated CD4 T cells in the SKG mouse model ...
Ashouri, Judith F, Chen, Yiling, Cheng, Debra A, Hansen, Erik, Hsu, Lih-Yun, Lattanza, Lisa, Rychkov, Dmitry, Sirota, Marina, Weiss, Arthur, Yu, Steven, Zikherman, Julie   +10 more
core  

Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL

Journal of Experimental Medicine
Diffuse large B cell lymphoma of activated B cell type (ABC-DLBCL), a major cell-of-origin DLBCL subtype, is characterized by chronic active B cell receptor (BCR) signaling and NF-κB activation, which can be explained by activating mutations of the BCR signaling cascade in a minority of cases.
Janneke A. Eken, Marvyn T. Koning, Kristyna Kupcova, Julieta H. Sepúlveda Yáñez, Ruben A.L. de Groen, Edwin Quinten, Jurriaan Janssen, Cornelis A.M. van Bergen, Joost S.P. Vermaat, Arjen Cleven, Marcelo A. Navarrete, Bauke Ylstra, Daphne de Jong, Ondrej Havranek, Hassan Jumaa, Hendrik Veelken   +15 more
openaire   +4 more sources

Natural killer cells in cancer immunotherapy

MedComm
Natural killer (NK) cells, as innate lymphocytes, possess cytotoxic capabilities and engage target cells through a repertoire of activating and inhibitory receptors.
DanRu Wang, LingYun Dou, LiHao Sui, Yiquan Xue, Sheng Xu   +4 more
doaj   +1 more source

The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer. [PDF]

, 1987
IL-2-dependent cell lines were established from normal peripheral blood T lymphocytes that express neither CD4 nor CD8 differentiation antigens. CD3+,4-,8- cell lines from 15 different donors failed to react with WT31, an mAb directed against the T cell ...
Allison, JP, Federspiel, NA, Lanier, LL, Littman, D, Phillips, JH, Ruitenberg, JJ, Weiss, A   +6 more
core  

The Memory Function of the B Cell Antigen Receptor

, 2015
Abstract Activated B lymphocytes preserve their antigen experience by differentiating into long-lived pools of antibody-secreting plasma cells or various types of memory B cells (MBCs). The former population constantly produces serum immunoglobulins with sufficient specificity and affinity to thwart infections with recurrent pathogens.
Jürgen, Wienands, Niklas, Engels
openaire   +2 more sources

Enhancing Natural Killer and CD8 + T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8 + T Cells with HLA-E Monospecific Monoclonal Antibodies [PDF]

, 2019
Cytotoxic NK/CD8+ T cells interact with MHC-I ligands on tumor cells through either activating or inhibiting receptors. One of the inhibitory receptors is CD94/NKG2A.
Asgharzadeh, Shahab, Devarajan, Asokan, Filippone, Edward J., Ravindranath, Mepur H.   +3 more
core   +1 more source

A Versatile High‐Throughput Single‐Cell Screening Platform for Profiling Antigen‐Specific Long‐Lived B Cells in Blood and Bone Marrow

Advanced Science
Antigen‐specific B cells play a crucial role in the long‐term immune response following infection or vaccination, differentiating into antibody‐secreting cells (ASCs) and memory B cells (MBCs).
Tian Zhao, Yuqing Lei, Chang Liu, Dong Zhang, Kaiyi Li, Sisi Shan, Chenyu Li, Zimeng Wei, Yuhan Yang, Ting Zhang, Kai Sun, Haoran Sun, Linqi Zhang, Peng Liu   +13 more
doaj   +1 more source